Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata

Mei Chuan Chen, Guei Jane Wang, Yueh Hsiung Kuo, Yin Ru Chiang, Ting Yu Cho, Yu Ming Ju, Tzong Huei Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Seven new isoprenyl phenolic ethers, namely fimbriethers A‒G (1‒7), were isolated from the fermented broth of the termite nest-derived medicinal fungus Xylaria fimbriata YMJ491. Their structures were determined by spectroscopic data analysis and compared with those reported. The effects of all the isolates at a concentration of 100 μM on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells were evaluated, and all of them exhibited NO production inhibitory activity with E max values ranging from 4.6 ± 2.0% to 49.7 ± 0.5% without significant cytotoxicity. In addition, these seven compounds did not alter phenylephrine-induced vasocontraction in isolated intact thoracic aortic rings from C57BL/6J mouse, indicating 1‒7 were not involved in the regulation of endothelial NOS-mediated NO production.

Original languageEnglish
Pages (from-to)111-117
Number of pages7
JournalJournal of Food and Drug Analysis
Volume27
Issue number1
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • Anti-inflammation
  • Fimbriether
  • Isoprenyl phenolic ether
  • Nitric oxide inhibition
  • Xylaria fimbriata

ASJC Scopus subject areas

  • Food Science
  • Pharmacology

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