Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata

Mei Chuan Chen, Guei Jane Wang, Yueh Hsiung Kuo, Yin Ru Chiang, Ting Yu Cho, Yu Ming Ju, Tzong Huei Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Seven new isoprenyl phenolic ethers, namely fimbriethers A‒G (1‒7), were isolated from the fermented broth of the termite nest-derived medicinal fungus Xylaria fimbriata YMJ491. Their structures were determined by spectroscopic data analysis and compared with those reported. The effects of all the isolates at a concentration of 100 μM on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells were evaluated, and all of them exhibited NO production inhibitory activity with E max values ranging from 4.6 ± 2.0% to 49.7 ± 0.5% without significant cytotoxicity. In addition, these seven compounds did not alter phenylephrine-induced vasocontraction in isolated intact thoracic aortic rings from C57BL/6J mouse, indicating 1‒7 were not involved in the regulation of endothelial NOS-mediated NO production.

Original languageEnglish
Pages (from-to)111-117
Number of pages7
JournalJournal of Food and Drug Analysis
Volume27
Issue number1
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Xylaria
Isoptera
termite mounds
Ethers
nitric oxide
ethers
Nitric Oxide
Fungi
phenylephrine
mice
Phenylephrine
chest
Inbred C57BL Mouse
lipopolysaccharides
Lipopolysaccharides
cytotoxicity
data analysis
macrophages
Thorax
Macrophages

Keywords

  • Anti-inflammation
  • Fimbriether
  • Isoprenyl phenolic ether
  • Nitric oxide inhibition
  • Xylaria fimbriata

ASJC Scopus subject areas

  • Food Science
  • Pharmacology

Cite this

Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata. / Chen, Mei Chuan; Wang, Guei Jane; Kuo, Yueh Hsiung; Chiang, Yin Ru; Cho, Ting Yu; Ju, Yu Ming; Lee, Tzong Huei.

In: Journal of Food and Drug Analysis, Vol. 27, No. 1, 01.01.2019, p. 111-117.

Research output: Contribution to journalArticle

Chen, Mei Chuan ; Wang, Guei Jane ; Kuo, Yueh Hsiung ; Chiang, Yin Ru ; Cho, Ting Yu ; Ju, Yu Ming ; Lee, Tzong Huei. / Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata. In: Journal of Food and Drug Analysis. 2019 ; Vol. 27, No. 1. pp. 111-117.
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