Isopentenyladenosine stimulates and inhibits mitosis of human lymphocytes treated with phytohemagglutinin

Robert C. Gallo, Jacqueline Whang-Peng, Seymour Perry

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Abstract

The plant cytokinin isopentenyladenosine, a component of yeast and mammalian transfer ribonucleic acid, is both a potent inhibitor and stimulator of DNA synthesis, transformation, and mitosis of the phytohemagglutinin- stimulated lymphocyte. The stage of the cell cycle and the concentrations used are critical for these effects. The addition of isopentenyladenosine within the first 12 hours after phytohemagglutinin at a concentration above 10-6 molar results in inhibition, while lower concentrations (between 10 -7 and 10-6 molar), added at 24 hours or later, have a stimulatory effect.

Original languageEnglish
Pages (from-to)400-402
Number of pages3
JournalScience
Volume165
Issue number3891
Publication statusPublished - Dec 1 1969
Externally publishedYes

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