Isoliquiritigenin inhibits cell proliferation and induces apoptosis in human hepatoma cells

Ya Ling Hsu, Po Lin Kuo, Liang Tzung Lin, Chun Ching Lin

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Isoliquiritigenin (4,2′,4′-trihydroxychalcone, ISL) is a natural pigment with a simple chalcone structure. In this study, we report the ISL-induced inhibition on the growth of human hepatoma cells (Hep G2) for the first time. The cell growth inhibition achieved by ISL treatment resulted in programmed cell death in a caspase activation-dependent manner, with an IC 50 of 10.51 μg/ mL. Outcomes of ISL treatment included the up-regulation of IκBα expression in the cytoplasm, and the decrease of NF-κB level as well as its activity in the nucleus. In addition, ISL also suppressed the expression of Bcl-XL and c-IAP1/2 protein, the down-stream target molecule of NF-κB. These results demonstrated that ISL treatment inhibited the NF-κB cell survival-signaling pathway and induced apoptotic cell death in Hep G2 cells.

Original languageEnglish
Pages (from-to)130-134
Number of pages5
JournalPlanta Medica
Volume71
Issue number2
DOIs
Publication statusPublished - Feb 2005
Externally publishedYes

Fingerprint

Hep G2 Cells
Cell proliferation
Cell death
hepatoma
Hepatocellular Carcinoma
cell proliferation
Cell Death
apoptosis
Cell Proliferation
Apoptosis
Inhibitor of Apoptosis Proteins
Cell signaling
Chalcone
chalcone
human growth
caspases
Cell growth
Growth
Caspases
Pigments

Keywords

  • Apoptosis
  • Caspase
  • IκBα
  • Isoliquiritigenin
  • NF-κB

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Isoliquiritigenin inhibits cell proliferation and induces apoptosis in human hepatoma cells. / Hsu, Ya Ling; Kuo, Po Lin; Lin, Liang Tzung; Lin, Chun Ching.

In: Planta Medica, Vol. 71, No. 2, 02.2005, p. 130-134.

Research output: Contribution to journalArticle

Hsu, Ya Ling ; Kuo, Po Lin ; Lin, Liang Tzung ; Lin, Chun Ching. / Isoliquiritigenin inhibits cell proliferation and induces apoptosis in human hepatoma cells. In: Planta Medica. 2005 ; Vol. 71, No. 2. pp. 130-134.
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