Isolation of Salmonella enterica serotype choleraesuis resistant to ceftriaxone and ciprofloxacin

C. H. Chiu, L. H. Su, C. Chu, J. H. Chia, T. L. Wu, T. Y. Lin, Y. S. Lee, J. T. Ou

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Abstract

Salmonella enterica serotype choleraesuis (S choleraesuis) usually causes systemic infections in man that need antimicrobial treatment. We isolated a strain of S choleraesuis that was resistant to ceftriaxone and ciprofloxacin from a patient with sepsis. Ciprofloxacin resistance was associated with mutations in gyrA and parC, whereas the ampC gene (blaCMY-2), responsible for ceftriaxone resistance, was carried by a transposon-like mobile element. This element was found inserted into finQ of a potentially transmissible 140 kb plasmid, with an 8 bp direct repeat flanking the junction regions. The appearance of this resistant S choleraesuis is a serious threat to public health, and thus constant surveillance is warranted.

Original languageEnglish
Pages (from-to)1285-1286
Number of pages2
JournalLancet
Volume363
Issue number9417
DOIs
Publication statusPublished - Apr 17 2004
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Chiu, C. H., Su, L. H., Chu, C., Chia, J. H., Wu, T. L., Lin, T. Y., Lee, Y. S., & Ou, J. T. (2004). Isolation of Salmonella enterica serotype choleraesuis resistant to ceftriaxone and ciprofloxacin. Lancet, 363(9417), 1285-1286. https://doi.org/10.1016/S0140-6736(04)16003-0