Isolated paraneoplastic optic neuropathy associated with acute lymphoblastic leukemia and collapsin response-mediating protein (CRMP-5) autoantibody

Tzu Lun Huang, Ruey Ho Kao, Yih Chun Lin, Rong Kung Tsai

Research output: Contribution to journalArticle

Abstract

We present a patient with leukemia associated with a CRMP-5-related paraneoplastic optic neuropathy (PON). A 30-year-old man with acute lymphoblastic leukemia (ALL) and complete chemotherapy suffered from a subacute painless visual loss in both eyes. His vision progressively decreased to 20/300 (OD) and 20/2000 (OS), respectively. Fundoscopy showed a massive disc edema (OS). Autoperimetry demonstrated generalized depression in both eyes. Magnetic resonance imaging (MRI) revealed swelling of left optic nerve at the orbital apex. Lumbar puncture examinations revealed a normal intracranial pressure and without tumor cell infiltration. CSF and serum for autoantibody examinations by using western blot showed a positive reaction to CRMP-5, but negative in myelin, voltage-dependent calcium channel alpha 1 (CACNA1), enolase and recoverin. Repeated lumbar puncture revealed a few immature myelomonocytic cells in CSF. Intravenous pulse therapy with Solu-Medrol associated with chemotherapy was administrated, the vision recovered to 20/40 (OD) and 20/60 (OS) within three days. One month later, his vision recovered to 20/20 (OD) and 20/30 (OS), as well as disc edema in left eye completely resolved. Paraneoplastic optic neuropathy should be in the differential considerations of disc edema in patients with malignancy.

Original languageEnglish
Pages (from-to)337-343
Number of pages7
JournalNeuro-Ophthalmology Japan
Volume27
Issue number3
Publication statusPublished - Sep 1 2010
Externally publishedYes

Fingerprint

Paraneoplastic Polyneuropathy
Semaphorin-3A
Optic Nerve Diseases
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Autoantibodies
Edema
Spinal Puncture
Recoverin
Methylprednisolone Hemisuccinate
Drug Therapy
Proteins
Phosphopyruvate Hydratase
Intracranial Pressure
Calcium Channels
Optic Nerve
Myelin Sheath
Neoplasms
Leukemia
Western Blotting
Magnetic Resonance Imaging

Keywords

  • Acute lymphoblastic leukemia
  • CRMP-5
  • Paraneoplastic optic neuropathy

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology

Cite this

Isolated paraneoplastic optic neuropathy associated with acute lymphoblastic leukemia and collapsin response-mediating protein (CRMP-5) autoantibody. / Huang, Tzu Lun; Kao, Ruey Ho; Lin, Yih Chun; Tsai, Rong Kung.

In: Neuro-Ophthalmology Japan, Vol. 27, No. 3, 01.09.2010, p. 337-343.

Research output: Contribution to journalArticle

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