Isokinetic eccentric exercise can induce skeletal muscle injury within the physiologic excursion of muscle-tendon unit: A rabbit model

Yang Hwei Tsuang, Shui Ling Lam, Lien Chen Wu, Chang Jung Chiang, Li Ting Chen, Pei Yu Chen, Jui Sheng Sun, Chien Che Wang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background and Purpose: Intensive eccentric exercise can cause muscle damage. We simulated an animal model of isokinetic eccentric exercise by repetitively stretching stimulated triceps surae muscle-tendon units to determine if such exercise affects the mechanical properties of the unit within its physiologic excursion. Methods: Biomechanical parameters of the muscle-tendon unit were monitored during isokinetic eccentric loading in 12 rabbits. In each animal, one limb (control group) was stretched until failure. The other limb (study group) was first subjected to isokinetic and eccentric cyclic loading at the rate of 10.0 cm/min to 112% (group I) or 120% (group II) of its initial length for 1 hour and then stretched to failure. Load-deformation curves and biomechanical parameters were compared between the study and control groups. Results: When the muscle-tendon unit received eccentric cyclic loading to 112%, changes in all biomechanical parameters - except for the slope of the load-deformation curve - were not significant. In contrast, most parameters, including the slope of the load-deformation curve, peak load, deformation at peak load, total energy absorption, and energy absorption before peak load, significantly decreased after isokinetic eccentric cyclic loading to 120%. Conclusion: We found a threshold for eccentrically induced injury of the rabbit triceps surae muscle at between 12% and 20% strain, which is within the physiologic excursion of the muscletendon units. Our study provided evidence that eccentric exercise may induce changes in the biomechanical properties of skeletal muscles, even within the physiologic range of the excursion of the muscle-tendon unit.

Original languageEnglish
Article number13
JournalJournal of Orthopaedic Surgery and Research
Volume2
Issue number1
DOIs
Publication statusPublished - 2007
Externally publishedYes

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Tendons
Skeletal Muscle
Rabbits
Muscles
Wounds and Injuries
Extremities
Control Groups
Animal Models

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Isokinetic eccentric exercise can induce skeletal muscle injury within the physiologic excursion of muscle-tendon unit : A rabbit model. / Tsuang, Yang Hwei; Lam, Shui Ling; Wu, Lien Chen; Chiang, Chang Jung; Chen, Li Ting; Chen, Pei Yu; Sun, Jui Sheng; Wang, Chien Che.

In: Journal of Orthopaedic Surgery and Research, Vol. 2, No. 1, 13, 2007.

Research output: Contribution to journalArticle

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abstract = "Background and Purpose: Intensive eccentric exercise can cause muscle damage. We simulated an animal model of isokinetic eccentric exercise by repetitively stretching stimulated triceps surae muscle-tendon units to determine if such exercise affects the mechanical properties of the unit within its physiologic excursion. Methods: Biomechanical parameters of the muscle-tendon unit were monitored during isokinetic eccentric loading in 12 rabbits. In each animal, one limb (control group) was stretched until failure. The other limb (study group) was first subjected to isokinetic and eccentric cyclic loading at the rate of 10.0 cm/min to 112{\%} (group I) or 120{\%} (group II) of its initial length for 1 hour and then stretched to failure. Load-deformation curves and biomechanical parameters were compared between the study and control groups. Results: When the muscle-tendon unit received eccentric cyclic loading to 112{\%}, changes in all biomechanical parameters - except for the slope of the load-deformation curve - were not significant. In contrast, most parameters, including the slope of the load-deformation curve, peak load, deformation at peak load, total energy absorption, and energy absorption before peak load, significantly decreased after isokinetic eccentric cyclic loading to 120{\%}. Conclusion: We found a threshold for eccentrically induced injury of the rabbit triceps surae muscle at between 12{\%} and 20{\%} strain, which is within the physiologic excursion of the muscletendon units. Our study provided evidence that eccentric exercise may induce changes in the biomechanical properties of skeletal muscles, even within the physiologic range of the excursion of the muscle-tendon unit.",
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