Ischemic heart disease induced by ingested inorganic arsenic

Chien-Jen Chen, Ju Li Lin, Yu-Mei Hsueh, Hung-Yi Chiou, Kun-Fu Liaw, Shan-Fa Horng, Ming Hsi Chiang, Chin Hsiao Tseng, Tung-Yuan Tai

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND PURPOSE: Circulatory diseases such as ischemic heart disease and peripheral vascular disease induced by long-term arsenic exposure have been well documented in previous studies, but the dose-response relationship between cerebrovascular disease and ingested inorganic arsenic remains to be elucidated. The prevalence of cerebrovascular disease among residents of the Lanyang Basin on the northeast coast of Taiwan was surveyed to examine its association with exposure to arsenic in well water. METHODS: A total of 8102 men and women from 3901 households were recruited in this study. The status of cerebrovascular disease of study subjects was identified through home-visit personal interviews and ascertained by review of hospital medical records according to the World Health Organization criteria. Information on consumption of well water,sociodemographic characteristics, cigarette smoking, and alcohol consumption habits, as well as personal and family history of diseases, was also obtained. Arsenic concentration in the well water of each household was determined by hydride generation and atomic absorption spectrometry. Logistic regression analysis was used to estimate multivariate-adjusted odds ratios and 95% confidence intervals for various risk factors of cerebrovascular disease. RESULTS: A significant doseresponse relationship was observed between arsenic concentration in well water and prevalence of cerebrovascular disease after adjustment for age, sex, hypertension, diabetes mellitus, cigarette smoking, and alcohol consumption. The biological gradient was even more prominent for cerebral infarction, showing multivariate-adjusted odds ratios of 1.0, 3.4, 4.5, and 6.9, respectively, for those who consumed well water with an arsenic content of 0, 0.1 to 50.0, 50.1 to 299.9, and > 300 micrograms/L. CONCLUSIONS: Long-term exposure to inorganic arsenic from well water was associated with an increased prevalence of cerebrovascular disease, especially cerebral infarction.
Original languageEnglish
Pages (from-to)83-90
Number of pages8
JournalArsenic Exposure and Health
Publication statusPublished - 1994

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Cerebrovascular Disorders
Arsenic
Myocardial Ischemia
Water
Cerebral Infarction
Alcohol Drinking
Smoking
Odds Ratio
House Calls
Peripheral Vascular Diseases
Hospital Records
Taiwan
Drinking
Habits
Medical Records
Spectrum Analysis
Diabetes Mellitus
Logistic Models
Regression Analysis
Confidence Intervals

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Ischemic heart disease induced by ingested inorganic arsenic. / Chen, Chien-Jen; Lin, Ju Li; Hsueh, Yu-Mei; Chiou, Hung-Yi; Liaw, Kun-Fu; Horng, Shan-Fa; Chiang, Ming Hsi; Tseng, Chin Hsiao; Tai, Tung-Yuan.

In: Arsenic Exposure and Health, 1994, p. 83-90.

Research output: Contribution to journalArticle

Chen, C-J, Lin, JL, Hsueh, Y-M, Chiou, H-Y, Liaw, K-F, Horng, S-F, Chiang, MH, Tseng, CH & Tai, T-Y 1994, 'Ischemic heart disease induced by ingested inorganic arsenic', Arsenic Exposure and Health, pp. 83-90.
Chen, Chien-Jen ; Lin, Ju Li ; Hsueh, Yu-Mei ; Chiou, Hung-Yi ; Liaw, Kun-Fu ; Horng, Shan-Fa ; Chiang, Ming Hsi ; Tseng, Chin Hsiao ; Tai, Tung-Yuan. / Ischemic heart disease induced by ingested inorganic arsenic. In: Arsenic Exposure and Health. 1994 ; pp. 83-90.
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abstract = "BACKGROUND AND PURPOSE: Circulatory diseases such as ischemic heart disease and peripheral vascular disease induced by long-term arsenic exposure have been well documented in previous studies, but the dose-response relationship between cerebrovascular disease and ingested inorganic arsenic remains to be elucidated. The prevalence of cerebrovascular disease among residents of the Lanyang Basin on the northeast coast of Taiwan was surveyed to examine its association with exposure to arsenic in well water. METHODS: A total of 8102 men and women from 3901 households were recruited in this study. The status of cerebrovascular disease of study subjects was identified through home-visit personal interviews and ascertained by review of hospital medical records according to the World Health Organization criteria. Information on consumption of well water,sociodemographic characteristics, cigarette smoking, and alcohol consumption habits, as well as personal and family history of diseases, was also obtained. Arsenic concentration in the well water of each household was determined by hydride generation and atomic absorption spectrometry. Logistic regression analysis was used to estimate multivariate-adjusted odds ratios and 95{\%} confidence intervals for various risk factors of cerebrovascular disease. RESULTS: A significant doseresponse relationship was observed between arsenic concentration in well water and prevalence of cerebrovascular disease after adjustment for age, sex, hypertension, diabetes mellitus, cigarette smoking, and alcohol consumption. The biological gradient was even more prominent for cerebral infarction, showing multivariate-adjusted odds ratios of 1.0, 3.4, 4.5, and 6.9, respectively, for those who consumed well water with an arsenic content of 0, 0.1 to 50.0, 50.1 to 299.9, and > 300 micrograms/L. CONCLUSIONS: Long-term exposure to inorganic arsenic from well water was associated with an increased prevalence of cerebrovascular disease, especially cerebral infarction.",
author = "Chien-Jen Chen and Lin, {Ju Li} and Yu-Mei Hsueh and Hung-Yi Chiou and Kun-Fu Liaw and Shan-Fa Horng and Chiang, {Ming Hsi} and Tseng, {Chin Hsiao} and Tung-Yuan Tai",
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T1 - Ischemic heart disease induced by ingested inorganic arsenic

AU - Chen, Chien-Jen

AU - Lin, Ju Li

AU - Hsueh, Yu-Mei

AU - Chiou, Hung-Yi

AU - Liaw, Kun-Fu

AU - Horng, Shan-Fa

AU - Chiang, Ming Hsi

AU - Tseng, Chin Hsiao

AU - Tai, Tung-Yuan

PY - 1994

Y1 - 1994

N2 - BACKGROUND AND PURPOSE: Circulatory diseases such as ischemic heart disease and peripheral vascular disease induced by long-term arsenic exposure have been well documented in previous studies, but the dose-response relationship between cerebrovascular disease and ingested inorganic arsenic remains to be elucidated. The prevalence of cerebrovascular disease among residents of the Lanyang Basin on the northeast coast of Taiwan was surveyed to examine its association with exposure to arsenic in well water. METHODS: A total of 8102 men and women from 3901 households were recruited in this study. The status of cerebrovascular disease of study subjects was identified through home-visit personal interviews and ascertained by review of hospital medical records according to the World Health Organization criteria. Information on consumption of well water,sociodemographic characteristics, cigarette smoking, and alcohol consumption habits, as well as personal and family history of diseases, was also obtained. Arsenic concentration in the well water of each household was determined by hydride generation and atomic absorption spectrometry. Logistic regression analysis was used to estimate multivariate-adjusted odds ratios and 95% confidence intervals for various risk factors of cerebrovascular disease. RESULTS: A significant doseresponse relationship was observed between arsenic concentration in well water and prevalence of cerebrovascular disease after adjustment for age, sex, hypertension, diabetes mellitus, cigarette smoking, and alcohol consumption. The biological gradient was even more prominent for cerebral infarction, showing multivariate-adjusted odds ratios of 1.0, 3.4, 4.5, and 6.9, respectively, for those who consumed well water with an arsenic content of 0, 0.1 to 50.0, 50.1 to 299.9, and > 300 micrograms/L. CONCLUSIONS: Long-term exposure to inorganic arsenic from well water was associated with an increased prevalence of cerebrovascular disease, especially cerebral infarction.

AB - BACKGROUND AND PURPOSE: Circulatory diseases such as ischemic heart disease and peripheral vascular disease induced by long-term arsenic exposure have been well documented in previous studies, but the dose-response relationship between cerebrovascular disease and ingested inorganic arsenic remains to be elucidated. The prevalence of cerebrovascular disease among residents of the Lanyang Basin on the northeast coast of Taiwan was surveyed to examine its association with exposure to arsenic in well water. METHODS: A total of 8102 men and women from 3901 households were recruited in this study. The status of cerebrovascular disease of study subjects was identified through home-visit personal interviews and ascertained by review of hospital medical records according to the World Health Organization criteria. Information on consumption of well water,sociodemographic characteristics, cigarette smoking, and alcohol consumption habits, as well as personal and family history of diseases, was also obtained. Arsenic concentration in the well water of each household was determined by hydride generation and atomic absorption spectrometry. Logistic regression analysis was used to estimate multivariate-adjusted odds ratios and 95% confidence intervals for various risk factors of cerebrovascular disease. RESULTS: A significant doseresponse relationship was observed between arsenic concentration in well water and prevalence of cerebrovascular disease after adjustment for age, sex, hypertension, diabetes mellitus, cigarette smoking, and alcohol consumption. The biological gradient was even more prominent for cerebral infarction, showing multivariate-adjusted odds ratios of 1.0, 3.4, 4.5, and 6.9, respectively, for those who consumed well water with an arsenic content of 0, 0.1 to 50.0, 50.1 to 299.9, and > 300 micrograms/L. CONCLUSIONS: Long-term exposure to inorganic arsenic from well water was associated with an increased prevalence of cerebrovascular disease, especially cerebral infarction.

UR - https://www.worldcat.org/title/arsenic-exposure-and-health/oclc/610846294&referer=brief_results

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