Is urodynamic study a good witness to the progression of ketamine-associated cystitis?

Po Wei Huang, Sheng Tang Wu, Chih Wei Tsao, Shou Hung Tang, Tai Lung Cha, Guang Huan Sun, Dah Shyong Yu, Sheng Yran Chang, En Meng

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: Ketamine abuse may cause variable lower urinary tract symptoms and severe cystitis. In this study, we evaluated the relevance of urodynamic parameters according to the dose and duration of ketamine use and investigate the value of urodynamic studies in determining the severity of ketamine-associated cystitis (KC). Methods: The urodynamic study results of 30 patients with KC between January 2009 and December 2012 were analyzed retrospectively. All patients had been diagnosed based on their history and clinical features before urodynamic investigations. Cystoscopy was performed to confirm the diagnosis and measure the maximum anesthetic bladder bladder capacity (MBC) (under spinal anesthesia). Results: The mean (± standard deviation) age of patients with KC was 22.0±3.3years. The mean duration of ketamine abuse was 39.0±20.8months. Maximum cystometric capacity was 115±66.6mL. Seventy-five percent of patients had a high maximal urethral closure pressure (MUCP) (>90cmH2O). There was no significant difference of urodynamic parameters between the high-dose (≥5gm/day) and low-dose groups (<5gm/day) or the long-duration (≥3years) and short-duration (<3years) groups. However, the MBC was significantly lower in high-dose and long-duration groups compared to the low-dose and short-duration groups (191.3±68.5 vs. 299.0±99mL; P=0.01; 219.0±59.7 vs. 325.5±104.5mL; P=0.002). Conclusions: The urodynamic test results help diagnose KC, but may not be useful in determining the severity of the disease. The MBC measured under anesthesia may be a better predictor of the disease progression in KC.

Original languageEnglish
Pages (from-to)98-102
Number of pages5
JournalLUTS: Lower Urinary Tract Symptoms
Volume6
Issue number2
DOIs
Publication statusPublished - Jan 1 2014
Externally publishedYes

Fingerprint

Cystitis
Urodynamics
Ketamine
Urinary Bladder
Lower Urinary Tract Symptoms
Cystoscopy
Spinal Anesthesia
Anesthetics
Disease Progression
Anesthesia
History
Pressure

Keywords

  • Cystitis
  • Ketamine
  • Maximum anesthetic bladder capacity
  • Urodynamics

ASJC Scopus subject areas

  • Neurology
  • Urology

Cite this

Huang, P. W., Wu, S. T., Tsao, C. W., Tang, S. H., Cha, T. L., Sun, G. H., ... Meng, E. (2014). Is urodynamic study a good witness to the progression of ketamine-associated cystitis? LUTS: Lower Urinary Tract Symptoms, 6(2), 98-102. https://doi.org/10.1111/luts.12029

Is urodynamic study a good witness to the progression of ketamine-associated cystitis? / Huang, Po Wei; Wu, Sheng Tang; Tsao, Chih Wei; Tang, Shou Hung; Cha, Tai Lung; Sun, Guang Huan; Yu, Dah Shyong; Chang, Sheng Yran; Meng, En.

In: LUTS: Lower Urinary Tract Symptoms, Vol. 6, No. 2, 01.01.2014, p. 98-102.

Research output: Contribution to journalArticle

Huang, PW, Wu, ST, Tsao, CW, Tang, SH, Cha, TL, Sun, GH, Yu, DS, Chang, SY & Meng, E 2014, 'Is urodynamic study a good witness to the progression of ketamine-associated cystitis?', LUTS: Lower Urinary Tract Symptoms, vol. 6, no. 2, pp. 98-102. https://doi.org/10.1111/luts.12029
Huang, Po Wei ; Wu, Sheng Tang ; Tsao, Chih Wei ; Tang, Shou Hung ; Cha, Tai Lung ; Sun, Guang Huan ; Yu, Dah Shyong ; Chang, Sheng Yran ; Meng, En. / Is urodynamic study a good witness to the progression of ketamine-associated cystitis?. In: LUTS: Lower Urinary Tract Symptoms. 2014 ; Vol. 6, No. 2. pp. 98-102.
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abstract = "Objectives: Ketamine abuse may cause variable lower urinary tract symptoms and severe cystitis. In this study, we evaluated the relevance of urodynamic parameters according to the dose and duration of ketamine use and investigate the value of urodynamic studies in determining the severity of ketamine-associated cystitis (KC). Methods: The urodynamic study results of 30 patients with KC between January 2009 and December 2012 were analyzed retrospectively. All patients had been diagnosed based on their history and clinical features before urodynamic investigations. Cystoscopy was performed to confirm the diagnosis and measure the maximum anesthetic bladder bladder capacity (MBC) (under spinal anesthesia). Results: The mean (± standard deviation) age of patients with KC was 22.0±3.3years. The mean duration of ketamine abuse was 39.0±20.8months. Maximum cystometric capacity was 115±66.6mL. Seventy-five percent of patients had a high maximal urethral closure pressure (MUCP) (>90cmH2O). There was no significant difference of urodynamic parameters between the high-dose (≥5gm/day) and low-dose groups (<5gm/day) or the long-duration (≥3years) and short-duration (<3years) groups. However, the MBC was significantly lower in high-dose and long-duration groups compared to the low-dose and short-duration groups (191.3±68.5 vs. 299.0±99mL; P=0.01; 219.0±59.7 vs. 325.5±104.5mL; P=0.002). Conclusions: The urodynamic test results help diagnose KC, but may not be useful in determining the severity of the disease. The MBC measured under anesthesia may be a better predictor of the disease progression in KC.",
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AU - Huang, Po Wei

AU - Wu, Sheng Tang

AU - Tsao, Chih Wei

AU - Tang, Shou Hung

AU - Cha, Tai Lung

AU - Sun, Guang Huan

AU - Yu, Dah Shyong

AU - Chang, Sheng Yran

AU - Meng, En

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N2 - Objectives: Ketamine abuse may cause variable lower urinary tract symptoms and severe cystitis. In this study, we evaluated the relevance of urodynamic parameters according to the dose and duration of ketamine use and investigate the value of urodynamic studies in determining the severity of ketamine-associated cystitis (KC). Methods: The urodynamic study results of 30 patients with KC between January 2009 and December 2012 were analyzed retrospectively. All patients had been diagnosed based on their history and clinical features before urodynamic investigations. Cystoscopy was performed to confirm the diagnosis and measure the maximum anesthetic bladder bladder capacity (MBC) (under spinal anesthesia). Results: The mean (± standard deviation) age of patients with KC was 22.0±3.3years. The mean duration of ketamine abuse was 39.0±20.8months. Maximum cystometric capacity was 115±66.6mL. Seventy-five percent of patients had a high maximal urethral closure pressure (MUCP) (>90cmH2O). There was no significant difference of urodynamic parameters between the high-dose (≥5gm/day) and low-dose groups (<5gm/day) or the long-duration (≥3years) and short-duration (<3years) groups. However, the MBC was significantly lower in high-dose and long-duration groups compared to the low-dose and short-duration groups (191.3±68.5 vs. 299.0±99mL; P=0.01; 219.0±59.7 vs. 325.5±104.5mL; P=0.002). Conclusions: The urodynamic test results help diagnose KC, but may not be useful in determining the severity of the disease. The MBC measured under anesthesia may be a better predictor of the disease progression in KC.

AB - Objectives: Ketamine abuse may cause variable lower urinary tract symptoms and severe cystitis. In this study, we evaluated the relevance of urodynamic parameters according to the dose and duration of ketamine use and investigate the value of urodynamic studies in determining the severity of ketamine-associated cystitis (KC). Methods: The urodynamic study results of 30 patients with KC between January 2009 and December 2012 were analyzed retrospectively. All patients had been diagnosed based on their history and clinical features before urodynamic investigations. Cystoscopy was performed to confirm the diagnosis and measure the maximum anesthetic bladder bladder capacity (MBC) (under spinal anesthesia). Results: The mean (± standard deviation) age of patients with KC was 22.0±3.3years. The mean duration of ketamine abuse was 39.0±20.8months. Maximum cystometric capacity was 115±66.6mL. Seventy-five percent of patients had a high maximal urethral closure pressure (MUCP) (>90cmH2O). There was no significant difference of urodynamic parameters between the high-dose (≥5gm/day) and low-dose groups (<5gm/day) or the long-duration (≥3years) and short-duration (<3years) groups. However, the MBC was significantly lower in high-dose and long-duration groups compared to the low-dose and short-duration groups (191.3±68.5 vs. 299.0±99mL; P=0.01; 219.0±59.7 vs. 325.5±104.5mL; P=0.002). Conclusions: The urodynamic test results help diagnose KC, but may not be useful in determining the severity of the disease. The MBC measured under anesthesia may be a better predictor of the disease progression in KC.

KW - Cystitis

KW - Ketamine

KW - Maximum anesthetic bladder capacity

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