Is the timing of implantation affected by Zona pellucida micromanipulation?

Ming I. Hsu, Gerardo Barroso, Jacob Mayer, Susan Lanzendorf, William E. Gibbons, Suheil Muasher, Sergio Oehninger

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: Our purpose was to examine the timing of implantation and early embryo development following uterine transfer of oocytes/embryos previously subjected to zona pellucida micromanipulation. Methods: A total of 68 singleton pregnancies resulting from IVF and embryo transfer with/without micromanipulation. Patients were divided into four groups according to the type of micromanipulation technique: assisted hatching, embryo biopsy, intracytoplasmic sperm injection, and no micromanipulation (control group). Serial serum β-hCG levels were measured between 10 and 25 days after fertilization and log-transformed. Linear regression analyses were performed and extrapolated to hCG = 10 mlU/ml (hCG10) to estimate detectable implantation. The slopes of the regression lines were used to estimate the rising speed of hCG, an indirect sign of embryo development. Results: There were no significant differences among groups with respect to hCG10, the slopes or intercepts of the regression lines. Conclusions: Various oocyte/embryo microsurgical procedures used in ART involving zona pellucida manipulation do not appear to affect the timing of implantation or early embryo development.

Original languageEnglish
Pages (from-to)34-38
Number of pages5
JournalJournal of Assisted Reproduction and Genetics
Volume17
Issue number1
DOIs
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

Micromanipulation
Zona Pellucida
Embryonic Development
Embryo Transfer
Oocytes
Embryonic Structures
Intracytoplasmic Sperm Injections
Fertilization
Linear Models
Regression Analysis
Biopsy
Pregnancy
Control Groups
Serum

Keywords

  • HCG
  • Implantation
  • Micromanipulation
  • Zona pellucida

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Developmental Biology
  • Genetics
  • Reproductive Medicine

Cite this

Is the timing of implantation affected by Zona pellucida micromanipulation? / Hsu, Ming I.; Barroso, Gerardo; Mayer, Jacob; Lanzendorf, Susan; Gibbons, William E.; Muasher, Suheil; Oehninger, Sergio.

In: Journal of Assisted Reproduction and Genetics, Vol. 17, No. 1, 2000, p. 34-38.

Research output: Contribution to journalArticle

Hsu, MI, Barroso, G, Mayer, J, Lanzendorf, S, Gibbons, WE, Muasher, S & Oehninger, S 2000, 'Is the timing of implantation affected by Zona pellucida micromanipulation?', Journal of Assisted Reproduction and Genetics, vol. 17, no. 1, pp. 34-38. https://doi.org/10.1023/A:1009497929994
Hsu, Ming I. ; Barroso, Gerardo ; Mayer, Jacob ; Lanzendorf, Susan ; Gibbons, William E. ; Muasher, Suheil ; Oehninger, Sergio. / Is the timing of implantation affected by Zona pellucida micromanipulation?. In: Journal of Assisted Reproduction and Genetics. 2000 ; Vol. 17, No. 1. pp. 34-38.
@article{4a15abd5fa3d4748839592283c940427,
title = "Is the timing of implantation affected by Zona pellucida micromanipulation?",
abstract = "Purpose: Our purpose was to examine the timing of implantation and early embryo development following uterine transfer of oocytes/embryos previously subjected to zona pellucida micromanipulation. Methods: A total of 68 singleton pregnancies resulting from IVF and embryo transfer with/without micromanipulation. Patients were divided into four groups according to the type of micromanipulation technique: assisted hatching, embryo biopsy, intracytoplasmic sperm injection, and no micromanipulation (control group). Serial serum β-hCG levels were measured between 10 and 25 days after fertilization and log-transformed. Linear regression analyses were performed and extrapolated to hCG = 10 mlU/ml (hCG10) to estimate detectable implantation. The slopes of the regression lines were used to estimate the rising speed of hCG, an indirect sign of embryo development. Results: There were no significant differences among groups with respect to hCG10, the slopes or intercepts of the regression lines. Conclusions: Various oocyte/embryo microsurgical procedures used in ART involving zona pellucida manipulation do not appear to affect the timing of implantation or early embryo development.",
keywords = "HCG, Implantation, Micromanipulation, Zona pellucida",
author = "Hsu, {Ming I.} and Gerardo Barroso and Jacob Mayer and Susan Lanzendorf and Gibbons, {William E.} and Suheil Muasher and Sergio Oehninger",
year = "2000",
doi = "10.1023/A:1009497929994",
language = "English",
volume = "17",
pages = "34--38",
journal = "Journal of Assisted Reproduction and Genetics",
issn = "1058-0468",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - Is the timing of implantation affected by Zona pellucida micromanipulation?

AU - Hsu, Ming I.

AU - Barroso, Gerardo

AU - Mayer, Jacob

AU - Lanzendorf, Susan

AU - Gibbons, William E.

AU - Muasher, Suheil

AU - Oehninger, Sergio

PY - 2000

Y1 - 2000

N2 - Purpose: Our purpose was to examine the timing of implantation and early embryo development following uterine transfer of oocytes/embryos previously subjected to zona pellucida micromanipulation. Methods: A total of 68 singleton pregnancies resulting from IVF and embryo transfer with/without micromanipulation. Patients were divided into four groups according to the type of micromanipulation technique: assisted hatching, embryo biopsy, intracytoplasmic sperm injection, and no micromanipulation (control group). Serial serum β-hCG levels were measured between 10 and 25 days after fertilization and log-transformed. Linear regression analyses were performed and extrapolated to hCG = 10 mlU/ml (hCG10) to estimate detectable implantation. The slopes of the regression lines were used to estimate the rising speed of hCG, an indirect sign of embryo development. Results: There were no significant differences among groups with respect to hCG10, the slopes or intercepts of the regression lines. Conclusions: Various oocyte/embryo microsurgical procedures used in ART involving zona pellucida manipulation do not appear to affect the timing of implantation or early embryo development.

AB - Purpose: Our purpose was to examine the timing of implantation and early embryo development following uterine transfer of oocytes/embryos previously subjected to zona pellucida micromanipulation. Methods: A total of 68 singleton pregnancies resulting from IVF and embryo transfer with/without micromanipulation. Patients were divided into four groups according to the type of micromanipulation technique: assisted hatching, embryo biopsy, intracytoplasmic sperm injection, and no micromanipulation (control group). Serial serum β-hCG levels were measured between 10 and 25 days after fertilization and log-transformed. Linear regression analyses were performed and extrapolated to hCG = 10 mlU/ml (hCG10) to estimate detectable implantation. The slopes of the regression lines were used to estimate the rising speed of hCG, an indirect sign of embryo development. Results: There were no significant differences among groups with respect to hCG10, the slopes or intercepts of the regression lines. Conclusions: Various oocyte/embryo microsurgical procedures used in ART involving zona pellucida manipulation do not appear to affect the timing of implantation or early embryo development.

KW - HCG

KW - Implantation

KW - Micromanipulation

KW - Zona pellucida

UR - http://www.scopus.com/inward/record.url?scp=0034102782&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034102782&partnerID=8YFLogxK

U2 - 10.1023/A:1009497929994

DO - 10.1023/A:1009497929994

M3 - Article

VL - 17

SP - 34

EP - 38

JO - Journal of Assisted Reproduction and Genetics

JF - Journal of Assisted Reproduction and Genetics

SN - 1058-0468

IS - 1

ER -