Is the endogenous peroxyl-radical scavenging capacity of plasma protective in systemic inflammatory disorders in humans?

Kelvin Tsai, Tai Ger Hsu, Chi Woon Kong, Kuan Chia Lin, L. U. Fung-Jou

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Systemic inflammatory response syndrome (SIRS) in humans is associated with heightened intravascular oxidative stress. The clinical significance of plasma endogenous antioxidative capability in SIRS remains undetermined. Time-sequence changes of plasma total radical-trapping antioxidant parameter (TRAP) and its components were measured in 135 patients with various clinical conditions leading to SIRS. The results were correlated with clinical parameters. Plasma TRAP significantly depressed upon diagnosis of SIRS (SIRS vs. healthy subjects (n = 50), 605.7 ± 20.4 vs. 803.4 ± 30.8 μM Trolox equivalent, p < .001). In survivors (n = 86), TRAP declined further during the course of SIRS, followed by a mild recovery at the end of follow-up. General linear mixed model analysis revealed that uric acid, vitamin C, vitamin E and unidentified antioxidants contributed to most of the changes in TRAP (each factor p < .001). In nonsurvivors (n = 49), TRAP increased steadily until death, and the increase was predominantly the result of the increased contribution of bilirubin (p < .01). Higher TRAP levels were not correlated with diminished blood oxidants formation (r = -0.13, p > .05), lower intensity of lipid peroxidation (r = 0.261, p < .05) or lesser disease severity of SIRS. The results do not support the hypothesis that the endogenous peroxyl radical scavenging ability of plasma plays a protective role in the course of SIRS. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)926-933
Number of pages8
JournalFree Radical Biology and Medicine
Volume28
Issue number6
DOIs
Publication statusPublished - Mar 15 2000
Externally publishedYes

Fingerprint

Systemic Inflammatory Response Syndrome
Scavenging
Plasmas
Antioxidants
Oxidative stress
Lipids
perhydroxyl radical
Lipid Peroxidation
Healthy Volunteers
Oxidative Stress

Keywords

  • Acute-phase reactions
  • Antioxidants
  • Chemiluminescence
  • Disease severity
  • Inflammation
  • Oxidative stress
  • Reactive oxygen species
  • Survival

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

Cite this

Is the endogenous peroxyl-radical scavenging capacity of plasma protective in systemic inflammatory disorders in humans? / Tsai, Kelvin; Hsu, Tai Ger; Kong, Chi Woon; Lin, Kuan Chia; Fung-Jou, L. U.

In: Free Radical Biology and Medicine, Vol. 28, No. 6, 15.03.2000, p. 926-933.

Research output: Contribution to journalArticle

Tsai, Kelvin ; Hsu, Tai Ger ; Kong, Chi Woon ; Lin, Kuan Chia ; Fung-Jou, L. U. / Is the endogenous peroxyl-radical scavenging capacity of plasma protective in systemic inflammatory disorders in humans?. In: Free Radical Biology and Medicine. 2000 ; Vol. 28, No. 6. pp. 926-933.
@article{aaba47b6b78d44f5ba3c3ea8cd992e75,
title = "Is the endogenous peroxyl-radical scavenging capacity of plasma protective in systemic inflammatory disorders in humans?",
abstract = "Systemic inflammatory response syndrome (SIRS) in humans is associated with heightened intravascular oxidative stress. The clinical significance of plasma endogenous antioxidative capability in SIRS remains undetermined. Time-sequence changes of plasma total radical-trapping antioxidant parameter (TRAP) and its components were measured in 135 patients with various clinical conditions leading to SIRS. The results were correlated with clinical parameters. Plasma TRAP significantly depressed upon diagnosis of SIRS (SIRS vs. healthy subjects (n = 50), 605.7 ± 20.4 vs. 803.4 ± 30.8 μM Trolox equivalent, p < .001). In survivors (n = 86), TRAP declined further during the course of SIRS, followed by a mild recovery at the end of follow-up. General linear mixed model analysis revealed that uric acid, vitamin C, vitamin E and unidentified antioxidants contributed to most of the changes in TRAP (each factor p < .001). In nonsurvivors (n = 49), TRAP increased steadily until death, and the increase was predominantly the result of the increased contribution of bilirubin (p < .01). Higher TRAP levels were not correlated with diminished blood oxidants formation (r = -0.13, p > .05), lower intensity of lipid peroxidation (r = 0.261, p < .05) or lesser disease severity of SIRS. The results do not support the hypothesis that the endogenous peroxyl radical scavenging ability of plasma plays a protective role in the course of SIRS. Copyright (C) 2000 Elsevier Science Inc.",
keywords = "Acute-phase reactions, Antioxidants, Chemiluminescence, Disease severity, Inflammation, Oxidative stress, Reactive oxygen species, Survival",
author = "Kelvin Tsai and Hsu, {Tai Ger} and Kong, {Chi Woon} and Lin, {Kuan Chia} and Fung-Jou, {L. U.}",
year = "2000",
month = "3",
day = "15",
doi = "10.1016/S0891-5849(00)00180-5",
language = "English",
volume = "28",
pages = "926--933",
journal = "Free Radical Biology and Medicine",
issn = "0891-5849",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Is the endogenous peroxyl-radical scavenging capacity of plasma protective in systemic inflammatory disorders in humans?

AU - Tsai, Kelvin

AU - Hsu, Tai Ger

AU - Kong, Chi Woon

AU - Lin, Kuan Chia

AU - Fung-Jou, L. U.

PY - 2000/3/15

Y1 - 2000/3/15

N2 - Systemic inflammatory response syndrome (SIRS) in humans is associated with heightened intravascular oxidative stress. The clinical significance of plasma endogenous antioxidative capability in SIRS remains undetermined. Time-sequence changes of plasma total radical-trapping antioxidant parameter (TRAP) and its components were measured in 135 patients with various clinical conditions leading to SIRS. The results were correlated with clinical parameters. Plasma TRAP significantly depressed upon diagnosis of SIRS (SIRS vs. healthy subjects (n = 50), 605.7 ± 20.4 vs. 803.4 ± 30.8 μM Trolox equivalent, p < .001). In survivors (n = 86), TRAP declined further during the course of SIRS, followed by a mild recovery at the end of follow-up. General linear mixed model analysis revealed that uric acid, vitamin C, vitamin E and unidentified antioxidants contributed to most of the changes in TRAP (each factor p < .001). In nonsurvivors (n = 49), TRAP increased steadily until death, and the increase was predominantly the result of the increased contribution of bilirubin (p < .01). Higher TRAP levels were not correlated with diminished blood oxidants formation (r = -0.13, p > .05), lower intensity of lipid peroxidation (r = 0.261, p < .05) or lesser disease severity of SIRS. The results do not support the hypothesis that the endogenous peroxyl radical scavenging ability of plasma plays a protective role in the course of SIRS. Copyright (C) 2000 Elsevier Science Inc.

AB - Systemic inflammatory response syndrome (SIRS) in humans is associated with heightened intravascular oxidative stress. The clinical significance of plasma endogenous antioxidative capability in SIRS remains undetermined. Time-sequence changes of plasma total radical-trapping antioxidant parameter (TRAP) and its components were measured in 135 patients with various clinical conditions leading to SIRS. The results were correlated with clinical parameters. Plasma TRAP significantly depressed upon diagnosis of SIRS (SIRS vs. healthy subjects (n = 50), 605.7 ± 20.4 vs. 803.4 ± 30.8 μM Trolox equivalent, p < .001). In survivors (n = 86), TRAP declined further during the course of SIRS, followed by a mild recovery at the end of follow-up. General linear mixed model analysis revealed that uric acid, vitamin C, vitamin E and unidentified antioxidants contributed to most of the changes in TRAP (each factor p < .001). In nonsurvivors (n = 49), TRAP increased steadily until death, and the increase was predominantly the result of the increased contribution of bilirubin (p < .01). Higher TRAP levels were not correlated with diminished blood oxidants formation (r = -0.13, p > .05), lower intensity of lipid peroxidation (r = 0.261, p < .05) or lesser disease severity of SIRS. The results do not support the hypothesis that the endogenous peroxyl radical scavenging ability of plasma plays a protective role in the course of SIRS. Copyright (C) 2000 Elsevier Science Inc.

KW - Acute-phase reactions

KW - Antioxidants

KW - Chemiluminescence

KW - Disease severity

KW - Inflammation

KW - Oxidative stress

KW - Reactive oxygen species

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=0034654263&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034654263&partnerID=8YFLogxK

U2 - 10.1016/S0891-5849(00)00180-5

DO - 10.1016/S0891-5849(00)00180-5

M3 - Article

C2 - 10802224

AN - SCOPUS:0034654263

VL - 28

SP - 926

EP - 933

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

SN - 0891-5849

IS - 6

ER -