Is a lower dose of cetrorelix acetate effective for prevention of LH surge during controlled ovarian hyperstimulation?

Heng J. Chen, Yu Hung Lin, Bih Chwen Hsieh, Kok M. Seow, Jiann-Loung Hwang, Chii Ruey Tzeng

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Purpose: This study was performed to evaluate whether a lower dose (0.2 mg) of cetrorelix would prevent premature LH surge in patients undergoing controlled ovarian hyperstimulation. Methods: Controlled ovarian hyperstimulation was carried out in 45 patients, starting on menstrual cycle day 3 with recombinant FSH (r-FSH), and a cetrorelix of 0.2 mg was administered from day 5 evening of ovarian stimulation until the day before hCG injection. Results: There was a statistically significant decrease in serum LH level one day after the first cetrorelix injection and on the day of hCG administration. Serum LH concentrations were maintained constantly low during the follicular phase with no premature LH surge occurring in any of the patients. Clinical pregnancy was achieved for 18 women (40%), with one of these experiencing intrauterine fetal death before 12 week' gestation. Conclusion: This study demonstrates that a daily dose of cetrorelix 0.2 mg is able to prevent premature LH surge.

Original languageEnglish
Pages (from-to)289-292
Number of pages4
JournalJournal of Assisted Reproduction and Genetics
Volume23
Issue number6
DOIs
Publication statusPublished - Jun 2006

Keywords

  • Cetrorelix
  • GnRH antagonist
  • In vitro fertilization
  • LH surge

ASJC Scopus subject areas

  • Developmental Biology
  • Genetics
  • Obstetrics and Gynaecology
  • Reproductive Medicine

Fingerprint Dive into the research topics of 'Is a lower dose of cetrorelix acetate effective for prevention of LH surge during controlled ovarian hyperstimulation?'. Together they form a unique fingerprint.

Cite this