Is a boosting dose of granulocyte-colony-stimulating factor necessary for healthy PBSC donors undergoing secondary apheresis? An institute's experience

Shu Huey Chen, Chi Jui Lu, Shu Hui Wen, Ya Jun Zheng, Shang Hsien Yang, Yu Chieh Su, Dian Kun Li

Research output: Contribution to journalArticle

Abstract

Successful allogeneic PBSC transplantation depends upon the infusion of an adequate number of CD34+ cells to patients. Granulocyte-colony-stimulating factors (G-CSF) mobilized PBSC were harvested on 5th day after stimulation from donors. When the CD34+ cell target yield was not achieved; secondary apheresis was performed the following day. Before September 2006, 67 donors (Group A) received five doses of G-CSF. After September 2006, a sixth dose of G-CSF was administered to 35 donors (Group B) to improve CD34+ yield. The mean CD34+-cell concentration of the second PBSC harvest was significantly higher in Group B (1,087 × 106/l vs. 767 × 106/l; P = 0.031).

Original languageEnglish
Pages (from-to)87-90
Number of pages4
JournalTransfusion and Apheresis Science
Volume40
Issue number2
DOIs
Publication statusPublished - Apr 2009
Externally publishedYes

ASJC Scopus subject areas

  • Hematology

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