Irritable bowel syndrome and the incidence of colorectal neoplasia

A prospective cohort study with community-based screened population in Taiwan

H. C. Chang, A. M F Yen, J. C Y Fann, S. Y H Chiu, C. S. Liao, H. H. Chen, K. C. Yang, L. S. Chen, Y. M. Lin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: We aim to report the prevalence of irritable bowel syndrome (IBS) and elucidate the influence of IBS on the incidence of colorectal neoplasm through a community-screening-based, longitudinal follow-up study. Methods: We enroled 39 384 community residents aged 40 years or older who had participated in a community-based colorectal cancer-screening programme with an immunochemical faecal occult test since 1999. We followed a cohort that was free of colorectal neoplasm (excluding colorectal neoplasm at baseline) to ascertain the incident colorectal neoplasm through each round of screening and used a nationwide cancer registry. Information on IBS was obtained by linking this screened cohort with population-based health insurance claim data. Other confounding factors were also collected via questionnaire or biochemical tests. Results: The overall period prevalence of IBS was 23%, increasing from 14.7% for subjects aged 40-49 years to 43.7% for those aged 70 years and more. After controlling for age, gender and family history of colorectal cancer, screenees who had been diagnosed as having IBS exhibited a significantly elevated level (21%; adjusted hazard ratio (HR)=1.21 (95% CI: 1.02-1.42)) of incident colorectal adenoma compared with those who had not been diagnosed with IBS. A similar finding was noted for invasive carcinoma; however, the size of the effect was of borderline statistical significance (adjusted HR=1.20 (95% CI: 0.94-1.53)). Conclusions: IBS led to an increased risk for incident colorectal neoplasm.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalBritish Journal of Cancer
Volume112
Issue number1
DOIs
Publication statusPublished - Jan 6 2015

Fingerprint

Irritable Bowel Syndrome
Taiwan
Colorectal Neoplasms
Cohort Studies
Prospective Studies
Incidence
Population
Neoplasms
Health Insurance
Early Detection of Cancer
Adenoma
Registries
Carcinoma

Keywords

  • colorectal neoplasm
  • irritable bowel syndrome
  • risk factor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Irritable bowel syndrome and the incidence of colorectal neoplasia : A prospective cohort study with community-based screened population in Taiwan. / Chang, H. C.; Yen, A. M F; Fann, J. C Y; Chiu, S. Y H; Liao, C. S.; Chen, H. H.; Yang, K. C.; Chen, L. S.; Lin, Y. M.

In: British Journal of Cancer, Vol. 112, No. 1, 06.01.2015, p. 171-176.

Research output: Contribution to journalArticle

Chang, H. C. ; Yen, A. M F ; Fann, J. C Y ; Chiu, S. Y H ; Liao, C. S. ; Chen, H. H. ; Yang, K. C. ; Chen, L. S. ; Lin, Y. M. / Irritable bowel syndrome and the incidence of colorectal neoplasia : A prospective cohort study with community-based screened population in Taiwan. In: British Journal of Cancer. 2015 ; Vol. 112, No. 1. pp. 171-176.
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