Irritable bowel syndrome and the incidence of colorectal neoplasia: A prospective cohort study with community-based screened population in Taiwan

H. C. Chang, A. M.F. Yen, J. C.Y. Fann, S. Y.H. Chiu, C. S. Liao, H. H. Chen, K. C. Yang, L. S. Chen, Y. M. Lin

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11 Citations (Scopus)

Abstract

Background: We aim to report the prevalence of irritable bowel syndrome (IBS) and elucidate the influence of IBS on the incidence of colorectal neoplasm through a community-screening-based, longitudinal follow-up study. Methods: We enroled 39 384 community residents aged 40 years or older who had participated in a community-based colorectal cancer-screening programme with an immunochemical faecal occult test since 1999. We followed a cohort that was free of colorectal neoplasm (excluding colorectal neoplasm at baseline) to ascertain the incident colorectal neoplasm through each round of screening and used a nationwide cancer registry. Information on IBS was obtained by linking this screened cohort with population-based health insurance claim data. Other confounding factors were also collected via questionnaire or biochemical tests. Results: The overall period prevalence of IBS was 23%, increasing from 14.7% for subjects aged 40-49 years to 43.7% for those aged 70 years and more. After controlling for age, gender and family history of colorectal cancer, screenees who had been diagnosed as having IBS exhibited a significantly elevated level (21%; adjusted hazard ratio (HR)=1.21 (95% CI: 1.02-1.42)) of incident colorectal adenoma compared with those who had not been diagnosed with IBS. A similar finding was noted for invasive carcinoma; however, the size of the effect was of borderline statistical significance (adjusted HR=1.20 (95% CI: 0.94-1.53)). Conclusions: IBS led to an increased risk for incident colorectal neoplasm.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalBritish Journal of Cancer
Volume112
Issue number1
DOIs
Publication statusPublished - Jan 6 2015

Keywords

  • colorectal neoplasm
  • irritable bowel syndrome
  • risk factor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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