Iron stores and obesity are negatively associated with ovarian volume and anti-Müllerian hormone levels in women with polycystic ovary syndrome

Jehn Hsiahn Yang, Chia Hung Chou, Wei Shiung Yang, Hong Nerng Ho, Yu Shih Yang, Mei Jou Chen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective Obesity and insulin resistance are associated with increased iron stores, but have conflicting effects on ovarian reserve in women with polycystic ovary syndrome (PCOS). Iron-catalyzed oxidative stress might be detrimental to ovarian tissue and granulosa cell function. In this study we determined the association between body iron stores, obesity, and ovarian reserve in women with PCOS. Materials and Methods One hundred and fifty-six women diagnosed with PCOS according to Rotterdam criteria and 30 normoweight healthy control women were enrolled in this cross-sectional study. Ovarian volume, total antral follicle count, and the anti-Müllerian hormone (AMH) level were measured as an indicator of ovarian reserve. Results Ferritin and transferrin-bound iron levels were significantly higher in women with PCOS than normoweight controls. Obese women with PCOS had higher ferritin levels (p = 0.006), but lower AMH levels (p < 0.0001) than nonobese women with PCOS. Using univariate analysis, the AMH level and mean ovarian volume were inversely related to the ferritin level, homeostasis model assessment of insulin resistance, and body mass index in women with PCOS. Body mass index and ferritin level remained significantly correlated with a lower AMH level and reduced ovarian volume, respectively, after considering other confounding variables. Conclusion An elevated ferritin level and obesity were negatively associated with ovarian volume and the AMH level, respectively, in women with PCOS.

Original languageEnglish
Pages (from-to)686-692
Number of pages7
JournalTaiwanese Journal of Obstetrics and Gynecology
Volume54
Issue number6
DOIs
Publication statusPublished - Dec 1 2015
Externally publishedYes

Fingerprint

Polycystic Ovary Syndrome
Iron
Obesity
Hormones
Ferritins
Insulin Resistance
Body Mass Index
Confounding Factors (Epidemiology)
Granulosa Cells
Transferrin
Oxidative Stress
Homeostasis
Cross-Sectional Studies

Keywords

  • anti-Müllerian hormone
  • ferritin
  • iron stores
  • obesity
  • ovarian volume

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Iron stores and obesity are negatively associated with ovarian volume and anti-Müllerian hormone levels in women with polycystic ovary syndrome. / Yang, Jehn Hsiahn; Chou, Chia Hung; Yang, Wei Shiung; Ho, Hong Nerng; Yang, Yu Shih; Chen, Mei Jou.

In: Taiwanese Journal of Obstetrics and Gynecology, Vol. 54, No. 6, 01.12.2015, p. 686-692.

Research output: Contribution to journalArticle

@article{b13838e3edb24720b90c1d5fa541cb05,
title = "Iron stores and obesity are negatively associated with ovarian volume and anti-M{\"u}llerian hormone levels in women with polycystic ovary syndrome",
abstract = "Objective Obesity and insulin resistance are associated with increased iron stores, but have conflicting effects on ovarian reserve in women with polycystic ovary syndrome (PCOS). Iron-catalyzed oxidative stress might be detrimental to ovarian tissue and granulosa cell function. In this study we determined the association between body iron stores, obesity, and ovarian reserve in women with PCOS. Materials and Methods One hundred and fifty-six women diagnosed with PCOS according to Rotterdam criteria and 30 normoweight healthy control women were enrolled in this cross-sectional study. Ovarian volume, total antral follicle count, and the anti-M{\"u}llerian hormone (AMH) level were measured as an indicator of ovarian reserve. Results Ferritin and transferrin-bound iron levels were significantly higher in women with PCOS than normoweight controls. Obese women with PCOS had higher ferritin levels (p = 0.006), but lower AMH levels (p < 0.0001) than nonobese women with PCOS. Using univariate analysis, the AMH level and mean ovarian volume were inversely related to the ferritin level, homeostasis model assessment of insulin resistance, and body mass index in women with PCOS. Body mass index and ferritin level remained significantly correlated with a lower AMH level and reduced ovarian volume, respectively, after considering other confounding variables. Conclusion An elevated ferritin level and obesity were negatively associated with ovarian volume and the AMH level, respectively, in women with PCOS.",
keywords = "anti-M{\"u}llerian hormone, ferritin, iron stores, obesity, ovarian volume",
author = "Yang, {Jehn Hsiahn} and Chou, {Chia Hung} and Yang, {Wei Shiung} and Ho, {Hong Nerng} and Yang, {Yu Shih} and Chen, {Mei Jou}",
year = "2015",
month = "12",
day = "1",
doi = "10.1016/j.tjog.2014.11.025",
language = "English",
volume = "54",
pages = "686--692",
journal = "Taiwanese Journal of Obstetrics and Gynecology",
issn = "1028-4559",
publisher = "臺灣婦產科醫學會",
number = "6",

}

TY - JOUR

T1 - Iron stores and obesity are negatively associated with ovarian volume and anti-Müllerian hormone levels in women with polycystic ovary syndrome

AU - Yang, Jehn Hsiahn

AU - Chou, Chia Hung

AU - Yang, Wei Shiung

AU - Ho, Hong Nerng

AU - Yang, Yu Shih

AU - Chen, Mei Jou

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Objective Obesity and insulin resistance are associated with increased iron stores, but have conflicting effects on ovarian reserve in women with polycystic ovary syndrome (PCOS). Iron-catalyzed oxidative stress might be detrimental to ovarian tissue and granulosa cell function. In this study we determined the association between body iron stores, obesity, and ovarian reserve in women with PCOS. Materials and Methods One hundred and fifty-six women diagnosed with PCOS according to Rotterdam criteria and 30 normoweight healthy control women were enrolled in this cross-sectional study. Ovarian volume, total antral follicle count, and the anti-Müllerian hormone (AMH) level were measured as an indicator of ovarian reserve. Results Ferritin and transferrin-bound iron levels were significantly higher in women with PCOS than normoweight controls. Obese women with PCOS had higher ferritin levels (p = 0.006), but lower AMH levels (p < 0.0001) than nonobese women with PCOS. Using univariate analysis, the AMH level and mean ovarian volume were inversely related to the ferritin level, homeostasis model assessment of insulin resistance, and body mass index in women with PCOS. Body mass index and ferritin level remained significantly correlated with a lower AMH level and reduced ovarian volume, respectively, after considering other confounding variables. Conclusion An elevated ferritin level and obesity were negatively associated with ovarian volume and the AMH level, respectively, in women with PCOS.

AB - Objective Obesity and insulin resistance are associated with increased iron stores, but have conflicting effects on ovarian reserve in women with polycystic ovary syndrome (PCOS). Iron-catalyzed oxidative stress might be detrimental to ovarian tissue and granulosa cell function. In this study we determined the association between body iron stores, obesity, and ovarian reserve in women with PCOS. Materials and Methods One hundred and fifty-six women diagnosed with PCOS according to Rotterdam criteria and 30 normoweight healthy control women were enrolled in this cross-sectional study. Ovarian volume, total antral follicle count, and the anti-Müllerian hormone (AMH) level were measured as an indicator of ovarian reserve. Results Ferritin and transferrin-bound iron levels were significantly higher in women with PCOS than normoweight controls. Obese women with PCOS had higher ferritin levels (p = 0.006), but lower AMH levels (p < 0.0001) than nonobese women with PCOS. Using univariate analysis, the AMH level and mean ovarian volume were inversely related to the ferritin level, homeostasis model assessment of insulin resistance, and body mass index in women with PCOS. Body mass index and ferritin level remained significantly correlated with a lower AMH level and reduced ovarian volume, respectively, after considering other confounding variables. Conclusion An elevated ferritin level and obesity were negatively associated with ovarian volume and the AMH level, respectively, in women with PCOS.

KW - anti-Müllerian hormone

KW - ferritin

KW - iron stores

KW - obesity

KW - ovarian volume

UR - http://www.scopus.com/inward/record.url?scp=84983546324&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84983546324&partnerID=8YFLogxK

U2 - 10.1016/j.tjog.2014.11.025

DO - 10.1016/j.tjog.2014.11.025

M3 - Article

C2 - 26700986

AN - SCOPUS:84983546324

VL - 54

SP - 686

EP - 692

JO - Taiwanese Journal of Obstetrics and Gynecology

JF - Taiwanese Journal of Obstetrics and Gynecology

SN - 1028-4559

IS - 6

ER -