Irinotecan (CPT11) plus high-dose 5-fluorouracil (5-FU) and leucovorin (LV) as salvage therapy for metastatic colorectal cancer (MCRC) after failed oxaliplatin plus 5-FU and LV: A pilot study in Taiwan

Cheng Jeng Tai, Jin Hwang Liu, Wei Shon Chen, Jen Kou Lin, Wei Shu Wang, Chueh Chuan Yen, Tzeon Jye Chiou, Po Min Chen

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Irinotecan (CPT11) has established activity against advanced colorectal cancer without cross-resistance with 5-fluorouracil + leucovorin-based therapy. We conducted this pilot study to evaluate the efficacy and tolerance of combination treatment with irinotecan and 5-fluorouracil (5-FU) for patients in whom combination treatment with oxaliplatin with 5-FU + leucovorin has failed. Methods: Patients were e nrolled in this study after oxaliplatin treatment had failed. The treatment protocol consisted of CPT11 (180 mg/m2 for 90 min) on day 1 and a 2 h infusion of 200 mg/m2 leucovorin followed by 400 mg/m2 5-FU as an intravenous bolus injection plus a 22 h continuous infusion of 600 mg/m2 5-FU. This regimen was repeated for two consecutive days every 2 weeks. Results: A total of 18 patients were eligible for this study and in total 144 cycles of therapy (median eight cycles) were given to these patients. Four patients (22.2% 95% CI: 8-36.4%) achieved an objective response of partial remission (PR) and an additional seven obtained stable disease (SD) status or minor response. The median duration of response was 8 months and 14 patients were alive at the end of the study. Hematological toxicity (neutropenia) was the most common serious side effect (29.2%), followed by gastrointestinal effects (diarrhea, 28.5%). Grade II-III diarrhea was experienced for at least one cycle by each patient. Conclusions: The results of treatment for patients after oxaliplatin failure are encouraging and this treatment protocol is also well tolerated by previously heavily treated patients.

Original languageEnglish
Pages (from-to)136-140
Number of pages5
JournalJapanese Journal of Clinical Oncology
Volume33
Issue number3
DOIs
Publication statusPublished - Mar 1 2003
Externally publishedYes

Keywords

  • Chemotherapy
  • Irinotecan
  • Metastatic colorectal cancer
  • Oxaliplatin

ASJC Scopus subject areas

  • Oncology

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