Iridium Oxide Nanoparticle–Protein Corona Neural Interfaces with Enhanced Electroactivity and Bioactivity Enable Electrically Manipulatable Physical and Chemical Neuronal Activation

Fu Erh Chan, Huei Min Syu, Te Yi Wang, Zheng Ting Tang, Chih Ning Huang, Jyh Fu Lee, Thierry Burnouf, Shang Hsiu Hu, Po Chun Chen, Wei Chen Huang

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Iridium oxide (IrOx) is a promising implantable electrode material owing to its remarkable neural stimulation capacity. However, presently, IrOx electrodes lack biocompatibility and bioactive interactions with nerve tissues. Application of polymeric surface coatings results in a weak physical adhesion at the organic/inorganic interface, which limits their wide-scale application. Herein, a smart iridium oxide-plasma protein (IrOx-PP) electrode with enhanced electroactivity, electrochemical stability, cytocompatibility, and bioactivity that can provide controllable topographical, electrical, and chemical stimuli to enhance neuronal activity is proposed. In the inorganic/organic nanoparticle (NP)-protein corona structures, the soft NP-corona led to repeated burst-to-zero-to-burst PP release, while the hard NP-corona with an ordered atomic structure enhanced the electrochemical stability and bioactivity. The incorporated PP resulted in a higher current storage capacity, lower impedance, better cell growth, and significant neurite outgrowth compared with those obtained with pristine IrOx. The application of electrical stimulation to IrOx-PP enabled simultaneous neuromodulation, on-demand PP release, and cell uptake, with a 2-fold higher cell density and significant neurite outgrowth on IrOx-PP than on pristine IrOx. This bioactive inorganic-organic hybrid electrode with the combined features of physical properties and improved neuromodulation is expected to be a revolutionary platform for efficient and biocompatible neural implantation.

Original languageEnglish
Article number2100694
JournalAdvanced Materials Interfaces
Volume8
Issue number16
DOIs
Publication statusPublished - Aug 23 2021

Keywords

  • controlled release
  • electrical stimulation
  • iridium oxide
  • nanoparticle–protein corona
  • neural interfaces
  • plasma protein

ASJC Scopus subject areas

  • Mechanics of Materials
  • Mechanical Engineering

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