Involvement of recepteur d'origine nantais receptor tyrosine kinase in Epstein-Barr virus-associated nasopharyngeal carcinoma and its metastasis

Ya Ching Chou, Chi Long Chen, Te Huei Yeh, Sue Jane Lin, Mei Ru Chen, Shin Lian Doong, Jean Lu, Ching Hwa Tsai

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Nasopharyngeal carcinoma (NPC) is characteristic for its strong association with Epstein-Barr virus (EBV) and high metastatic rate. Recently, overexpressed recepteur d'origine nantais (RON) (MST1R), receptor tyrosine kinase has been reported in human cancers and tumor metastasis. Therefore, the role of RON in EBV-associated NPC and its metastasis was investigated. Here we show that RON was found in NPC but not in control tissues. A significant correlation of latent membrane protein 1 (LMP1) and RON expression was found in NPC (Pearson's χ2 test; P = 0.0023). At the molecular level, LMP1 stimulates nuclear factor-κB binding to the RON promoter through its carboxyl-terminal activation region 1 to induce expression of RON. Knockdown of RON in cells expressing LMP1 significantly reverses LMP1-induced epithelial-mesenchymal transition and suppresses LMP1-induced cell migration and invasion. These results suggest an important role of RON in the tumorigenesis and metastasis of NPC and RON may be a novel therapeutic target for EBV-associated NPC.

Original languageEnglish
Pages (from-to)1773-1781
Number of pages9
JournalAmerican Journal of Pathology
Volume181
Issue number5
DOIs
Publication statusPublished - Nov 2012

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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