Involvement of nigrostriatal pathway in japanese encephalitis with movement disorders: Evidence from 99mTc-TRODAT-1 and 123I-IBZM SPECT imagings

Chang Hsu Liao, Zaodung Ling, Chung Hsing Chou, Wen Sheng Huang, Jong Chyou Denq, Jiann Chyun Lin, Cheng Yu Chen, Chia Jung Chang, Giia Sheun Peng

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Purpose: The purpose of this study was to evaluate molecular evidence of nigrostriatal pathway involvement in Japanese encephalitis (JE) survivors with movement complications. Methods: Three JE patients were recruited. All had cranial magnetic resonance imaging (MRI) and single-photon emission computed tomography (SPECT) studies with 99mTc-TRODAT-1 and 123I-IBZM. Results: Cranial MRI revealed involvement of bilateral thalami, substantia nigra, and medial temporal lobes in all three patients, but only case 1 had additional bilateral basal ganglia involvement. The 99mTc-TRODAT-1 SPECT for presynaptic dopamine transporter imaging disclosed asymmetrical decreases in bilateral striatal uptake in all three patients. However, the 123I-IBZM SPECT imaging for postsynaptic D2 dopamine receptors (D2Rs) revealed inconsistent abnormalities including asymmetrical bilateral decreases (case 1), unilateral decrease (case 2), and bilateral increases (case 3) in striatal uptakes. Conclusion: Data have suggested that presynaptic dopaminergic neurons in JE patients are more susceptible to JE virus than postsynaptic striatal neurons. The degree of movement impairment was more closely correlated to the degree of D2Rs disruption seen in 123I-IBZM SPECT imaging.

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalMolecular Imaging and Biology
Issue number1
Publication statusPublished - Feb 2010
Externally publishedYes


  • I-IBZM
  • Japanese encephalitis
  • Single photon emission computed tomography (SPECT)
  • Tc-TRODAT-1

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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