Involvement of both opiate and catecholaminergic receptors of ventromedial hypothalamus in the locomotor stimulant action of thyrotropin-releasing hormone

L. S. Lin, W. T. Chiu, C. J. Shih, M. T. Lin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To explore the mode of the locomotor stimulant action of thyrotropin-releasing hormone (TRH), rats with or without administration of opiate or catecholaminergic receptor antagonists were infused with TRH through previously implanted hypothalamic cannula. Administration of TRH, but not the normal saline or TSH, into the ventromedial hypothalamus caused an enhancement in both the gross movements (including stimulation of forward locomotion, head and body rearing) and fine movements (including increased grooming and head swaying). The locomotor stimulant action provoked by TRH was antagonized by pretreatment of ventromedial hypothalamus with either an alpha-adrenergic receptor antagonist (yohimbine), a dopaminergic receptor antagonist (haloperidol) or an opiate receptor antagonist (naloxone), but not with a beta-adrenergic receptor antagonist (propranolol). The results indicate that all the adrenergic, dopaminergic and opiate receptors in the ventromedial hypothalamus are involved in the TRH-induced hyperactivity in the rat.

Original languageEnglish
Pages (from-to)217-225
Number of pages9
JournalJournal of Neural Transmission
Volume68
Issue number3-4
DOIs
Publication statusPublished - Sep 1987
Externally publishedYes

    Fingerprint

Keywords

  • adrenergic receptors
  • dopaminergic receptors
  • Locomotor activity
  • opiate receptors
  • thyrotropin-releasing hormone
  • ventromedial hypothalamus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this