Investigation of subcortical gray matter in patients with non-lesional neocortical focal epilepsy

Ying Chi Fan, Syu Jyun Peng, Tomor Harnod, Chien Chun Huang, Yue Loong Hsin

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate whether there is any change in the subcortical gray matter of patients with neocortical focal epilepsy without visible magnetic resonance imaging (MRI) abnormalities. Methods: MRI morphometric parameter data from 24 patients and 29 neurologically normal controls were analyzed. All of the MRI scans were reported to have no any anomaly. Differences were evaluated by vertex-wise shape analysis. Results: A shape analysis showed significant surface reductions at the anterior-ventral and the posteriordorsal aspects of the bilateral thalami, the global left caudate nucleus, part of the bilateral dorsal putamen and the left hippocampus. Conclusion: Patients with focal seizures and secondary generalization had smaller volumes and microstructural anomalies in subcortical gray matter regions.

Original languageEnglish
Pages (from-to)124-128
Number of pages5
JournalActa Neurologica Taiwanica
Volume23
Issue number4
Publication statusPublished - Jan 1 2014
Externally publishedYes

Fingerprint

Partial Epilepsy
Magnetic Resonance Imaging
Caudate Nucleus
Putamen
Thalamus
Hippocampus
Seizures
Gray Matter

Keywords

  • Focal neocortical epilepsy
  • Subcortical structures
  • Vertex analysis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Investigation of subcortical gray matter in patients with non-lesional neocortical focal epilepsy. / Fan, Ying Chi; Peng, Syu Jyun; Harnod, Tomor; Huang, Chien Chun; Hsin, Yue Loong.

In: Acta Neurologica Taiwanica, Vol. 23, No. 4, 01.01.2014, p. 124-128.

Research output: Contribution to journalArticle

Fan, Ying Chi ; Peng, Syu Jyun ; Harnod, Tomor ; Huang, Chien Chun ; Hsin, Yue Loong. / Investigation of subcortical gray matter in patients with non-lesional neocortical focal epilepsy. In: Acta Neurologica Taiwanica. 2014 ; Vol. 23, No. 4. pp. 124-128.
@article{cc8bbf570af74c8c8baabee0c01a0954,
title = "Investigation of subcortical gray matter in patients with non-lesional neocortical focal epilepsy",
abstract = "Purpose: To investigate whether there is any change in the subcortical gray matter of patients with neocortical focal epilepsy without visible magnetic resonance imaging (MRI) abnormalities. Methods: MRI morphometric parameter data from 24 patients and 29 neurologically normal controls were analyzed. All of the MRI scans were reported to have no any anomaly. Differences were evaluated by vertex-wise shape analysis. Results: A shape analysis showed significant surface reductions at the anterior-ventral and the posteriordorsal aspects of the bilateral thalami, the global left caudate nucleus, part of the bilateral dorsal putamen and the left hippocampus. Conclusion: Patients with focal seizures and secondary generalization had smaller volumes and microstructural anomalies in subcortical gray matter regions.",
keywords = "Focal neocortical epilepsy, Subcortical structures, Vertex analysis",
author = "Fan, {Ying Chi} and Peng, {Syu Jyun} and Tomor Harnod and Huang, {Chien Chun} and Hsin, {Yue Loong}",
year = "2014",
month = "1",
day = "1",
language = "English",
volume = "23",
pages = "124--128",
journal = "Acta Neurologica Taiwanica",
issn = "1019-6099",
publisher = "Taiwan Neurological Society",
number = "4",

}

TY - JOUR

T1 - Investigation of subcortical gray matter in patients with non-lesional neocortical focal epilepsy

AU - Fan, Ying Chi

AU - Peng, Syu Jyun

AU - Harnod, Tomor

AU - Huang, Chien Chun

AU - Hsin, Yue Loong

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Purpose: To investigate whether there is any change in the subcortical gray matter of patients with neocortical focal epilepsy without visible magnetic resonance imaging (MRI) abnormalities. Methods: MRI morphometric parameter data from 24 patients and 29 neurologically normal controls were analyzed. All of the MRI scans were reported to have no any anomaly. Differences were evaluated by vertex-wise shape analysis. Results: A shape analysis showed significant surface reductions at the anterior-ventral and the posteriordorsal aspects of the bilateral thalami, the global left caudate nucleus, part of the bilateral dorsal putamen and the left hippocampus. Conclusion: Patients with focal seizures and secondary generalization had smaller volumes and microstructural anomalies in subcortical gray matter regions.

AB - Purpose: To investigate whether there is any change in the subcortical gray matter of patients with neocortical focal epilepsy without visible magnetic resonance imaging (MRI) abnormalities. Methods: MRI morphometric parameter data from 24 patients and 29 neurologically normal controls were analyzed. All of the MRI scans were reported to have no any anomaly. Differences were evaluated by vertex-wise shape analysis. Results: A shape analysis showed significant surface reductions at the anterior-ventral and the posteriordorsal aspects of the bilateral thalami, the global left caudate nucleus, part of the bilateral dorsal putamen and the left hippocampus. Conclusion: Patients with focal seizures and secondary generalization had smaller volumes and microstructural anomalies in subcortical gray matter regions.

KW - Focal neocortical epilepsy

KW - Subcortical structures

KW - Vertex analysis

UR - http://www.scopus.com/inward/record.url?scp=84927161367&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927161367&partnerID=8YFLogxK

M3 - Article

C2 - 26082416

AN - SCOPUS:84927161367

VL - 23

SP - 124

EP - 128

JO - Acta Neurologica Taiwanica

JF - Acta Neurologica Taiwanica

SN - 1019-6099

IS - 4

ER -