Investigation of DNA sequencing droplet trajectory observation and analysis

Jian Chiun Liou, Cheng Fu Yang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In this study, DNA sequencing droplet trajectories are observed and analyzed using an application-specific integrated circuit system and a micro-electromechanical system structure jetting chip. We investigate a droplet jetting technique and apply it to biomedical test chips. This use of a sprayed chip structure can reduce sequencing time by two-thirds compared with traditional methods. The structure is a three-dimensional, multi-channel drive system that can control droplets more precisely. The circuit's input control signal was generated and placed on a chip based on the quantitative design of liquid droplets. Delay time and frequency were used to set the LED light sources. In this study, we would use frequencies of 4 kHz, 8 kHz, and 12 kHz combined with two groups of different orifices and frequencies for ink droplet outlet velocity.

Original languageEnglish
Pages (from-to)243-250
Number of pages8
JournalMicroelectronics Reliability
Volume91
DOIs
Publication statusPublished - Dec 1 2018

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Keywords

  • DNA gene
  • Jets matrix
  • Micro-droplet
  • Multidimensional drive

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Safety, Risk, Reliability and Quality
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Electrical and Electronic Engineering

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