Investigation of differences on functional connectivity in major depressive disorder using functional magnetic resonance imaging

2010 International Conference on Bioinformatics and Biomedical Technology, ICBBT 2010

Shin Teng, Chia-Feng Lu, Yu-Te Wu, Po-Shan Wang, Tze-Chen Yeh, Tung-Ping Su, Jen-Chuen Hsieh, Int. Assoc. Comput. Sci. Inf. Technol. (IACSIT)

Research output: Contribution to conferenceOther

Abstract

Major depressive disorder (MDD) is one of the most common affective disorders which ranks among the top causes of worldwide disease burden and disability. Recent studies suggested that MDD resulted in the functional connectivity alteration in the resting state brain networks, such as the emotional circuit and the default mode network (DMN). In addition to these emotion-relevant networks, some other brain regions, such as cuneus gyrus, lingual gyrus and precuneus gyrus, were reported that the activity reduced while performing cognitive tasks. In this study, we examined three networks, i.e. the emotional circuit, the default mode network, and the whole brain network, derived from resting-state functional magnetic resonance imaging (fMRI) to investigate the difference between MDD patients and normal subjects. Furthermore, we explored whether there is another network affected by MDD. The functional MRI data was acquired from 22 healthy subjects and 20 patients with MDD. All images of each subject were parcellated into 90 cortical and sub-cortical regions which were defined as the nodes of the network. The functional relations between the 90 regions were estimated by the time-frequency normalized mutual information (TFNMI). We found that the functional connectivity between any pair of brain regions within each of the three networks was significantly decreased in MDD group by using the t test. The significantly decreased connectivity for MDD in emotional circuit was found in the frontal lobe and between the frontal cortex and limbic regions, and that in DMN exhibited between the frontal cortex and superior temporal cortex. However, in the whole brain network, the most significantly decreased connectivity was revealed in occipital lobe, parietal-occipital, and frontal-occipital regions. Our findings suggested that the functional brain network affected by MDD comprised not only the frontal and limbic regions but also the parts of the parietal and occipital lobe. © 2010 IEEE.
Original languageEnglish
Pages115-119
Number of pages5
DOIs
Publication statusPublished - 2010
Externally publishedYes

Fingerprint

Biomedical Technology
Major Depressive Disorder
Computational Biology
Occipital Lobe
Magnetic Resonance Imaging
Brain
Frontal Lobe
Parietal Lobe
Temporal Lobe
Mood Disorders
Healthy Volunteers
Emotions

Keywords

  • Functional connecitivy
  • Functional MRI
  • Major depressive disorder
  • Time-frequency normalized mutual information
  • Brain networks
  • Brain regions
  • Cognitive task
  • Cortical regions
  • Frontal cortex
  • Frontal lobes
  • Functional connectivity
  • Functional magnetic resonance imaging
  • Functional relation
  • Healthy subjects
  • Normalized mutual information
  • Resting state
  • T-tests
  • Time frequency
  • Bioinformatics
  • Brain
  • Magnetic resonance
  • Magnetic resonance imaging

Cite this

Investigation of differences on functional connectivity in major depressive disorder using functional magnetic resonance imaging : 2010 International Conference on Bioinformatics and Biomedical Technology, ICBBT 2010. / Teng, Shin; Lu, Chia-Feng; Wu, Yu-Te; Wang, Po-Shan; Yeh, Tze-Chen; Su, Tung-Ping; Hsieh, Jen-Chuen; (IACSIT), Int. Assoc. Comput. Sci. Inf. Technol.

2010. 115-119.

Research output: Contribution to conferenceOther

Teng, Shin ; Lu, Chia-Feng ; Wu, Yu-Te ; Wang, Po-Shan ; Yeh, Tze-Chen ; Su, Tung-Ping ; Hsieh, Jen-Chuen ; (IACSIT), Int. Assoc. Comput. Sci. Inf. Technol. / Investigation of differences on functional connectivity in major depressive disorder using functional magnetic resonance imaging : 2010 International Conference on Bioinformatics and Biomedical Technology, ICBBT 2010. 5 p.
@conference{42f2c29293824b7e9d0454de130ab086,
title = "Investigation of differences on functional connectivity in major depressive disorder using functional magnetic resonance imaging: 2010 International Conference on Bioinformatics and Biomedical Technology, ICBBT 2010",
abstract = "Major depressive disorder (MDD) is one of the most common affective disorders which ranks among the top causes of worldwide disease burden and disability. Recent studies suggested that MDD resulted in the functional connectivity alteration in the resting state brain networks, such as the emotional circuit and the default mode network (DMN). In addition to these emotion-relevant networks, some other brain regions, such as cuneus gyrus, lingual gyrus and precuneus gyrus, were reported that the activity reduced while performing cognitive tasks. In this study, we examined three networks, i.e. the emotional circuit, the default mode network, and the whole brain network, derived from resting-state functional magnetic resonance imaging (fMRI) to investigate the difference between MDD patients and normal subjects. Furthermore, we explored whether there is another network affected by MDD. The functional MRI data was acquired from 22 healthy subjects and 20 patients with MDD. All images of each subject were parcellated into 90 cortical and sub-cortical regions which were defined as the nodes of the network. The functional relations between the 90 regions were estimated by the time-frequency normalized mutual information (TFNMI). We found that the functional connectivity between any pair of brain regions within each of the three networks was significantly decreased in MDD group by using the t test. The significantly decreased connectivity for MDD in emotional circuit was found in the frontal lobe and between the frontal cortex and limbic regions, and that in DMN exhibited between the frontal cortex and superior temporal cortex. However, in the whole brain network, the most significantly decreased connectivity was revealed in occipital lobe, parietal-occipital, and frontal-occipital regions. Our findings suggested that the functional brain network affected by MDD comprised not only the frontal and limbic regions but also the parts of the parietal and occipital lobe. {\circledC} 2010 IEEE.",
keywords = "Functional connecitivy, Functional MRI, Major depressive disorder, Time-frequency normalized mutual information, Brain networks, Brain regions, Cognitive task, Cortical regions, Frontal cortex, Frontal lobes, Functional connectivity, Functional magnetic resonance imaging, Functional relation, Healthy subjects, Normalized mutual information, Resting state, T-tests, Time frequency, Bioinformatics, Brain, Magnetic resonance, Magnetic resonance imaging",
author = "Shin Teng and Chia-Feng Lu and Yu-Te Wu and Po-Shan Wang and Tze-Chen Yeh and Tung-Ping Su and Jen-Chuen Hsieh and (IACSIT), {Int. Assoc. Comput. Sci. Inf. Technol.}",
note = "會議代碼: 81050 Export Date: 31 March 2016 通訊地址: Teng, S.; Dept. of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan; 電子郵件: 1iamtengshin@yahoo.com.tw 參考文獻: (2001) The World Health Report., , http://www.who.int;, Chap 2, 4; Mayberg, H.S., Liotti, S.K., Brannan, M., McGinnis, S., Mahurin, R.K., Jerabek, P.A., Reciprocal limbic-cortical function and negative mood: Converging PET findings in depression and normal sadness (1999) Am J Psychiatry, 156, pp. 675-682; Drevets, W.C., Price, J.L., Simpson Jr., J.R., Todd, R.D., Reich, T., Vannier, M., Subgenual prefrontal cortex abnormalities in mood disorders (1997) Nature, 386, pp. 824-827; Drevets, W.C., Neuroimaging studies of mood disorders. (2000) Biol Psychiatry, 48, pp. 813-829; Sheline, Y.I., Barch, D.M., Ollinger, J.M., Donnelly, J.M., Snyder, A.Z., Mintun, M.A., Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: An fMRI study (2001) Biol Psychiatry, 50, pp. 651-658; Anand, A., Li, Y., Wang, Y., Wu, J.W., Gao, S.J., Bukhari, L.B., Mathews, V.P., Lowe, M.J., Activity and connectivity of brain mood regulating circuit in depression: A functional magnetic resonance study (2005) Biol Psychiatry, 57, pp. 1079-1088; Greicius, M.D., Flores, B.H., Menon, V., Glover, G.H., Solvason, H.B., Kenna, H., Reiss, A.L., Schatzberg, A.F., Resting-state functional connectivity in major depression: Abnormally increased contributions from subgenual cingulate cortex and thalamus (2007) Biol Psychiatry, 62, pp. 429-437; Sheline, Y.I., Barch, D.M., Price, J.L., Rundle, M.M., Vaishnavi, S.N., Snyder, A.Z., Mintun, M.A., Raichle, M.E., The default mode network and self-referential processes in depression (2009) PNAS, 106, pp. 1942-1947; Malhi, G.S., Lagopoulos, J., Owen, A.M., Ivanovski, B., Shnier, R., Sachdev, P., Reduced activation to implicit affect induction in euthymic bipolar patients: An fMRI study (2007) Journal of Affective Disorders, 97, pp. 109-122; Pavuluri, M.N., Passarotti, A.M., Harral, E.M., Sweeney, J.A., An fMRI study of the neural correlates of incidental versus directed emotion processing in pediatric bipolar disorder (2009) J. Am. Acad. Child Adolesc. Psychiatry, 48, pp. 308-319; Tzourio-Mazoyer, N., Landeau, N., Papathanassiou, B., Crivello, D., Etard, F., Delcroix, O., Mazoyer, B., Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain (2002) NeuroImage, 15, pp. 273-289; Fraser, A.M., Swinney, H.L., Independent coordinates for strange attractors from mutual information (1986) Physical Review A, 33, pp. 1134-1140; Drevets, W.C., Price, J.L., Furey, M.L., Brain structural and functional abnormalities in mood disorders: Implications for neurocircuitry models of depression (2008) Brain Struct Funct, 213, pp. 93-118; Phillips, M.L., Drevets, W.C., Rauch, S.L., Lane, R., Neurobiology of emotion perception II: Implications for major psychiatric disorders (2003) Biol Psychiatry, 54, pp. 515-528; Ong{\"u}r, D., Price, J.L., The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans (2000) Cereb Cortex, 10, pp. 206-219",
year = "2010",
doi = "10.1109/ICBBT.2010.5478999",
language = "English",
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TY - CONF

T1 - Investigation of differences on functional connectivity in major depressive disorder using functional magnetic resonance imaging

T2 - 2010 International Conference on Bioinformatics and Biomedical Technology, ICBBT 2010

AU - Teng, Shin

AU - Lu, Chia-Feng

AU - Wu, Yu-Te

AU - Wang, Po-Shan

AU - Yeh, Tze-Chen

AU - Su, Tung-Ping

AU - Hsieh, Jen-Chuen

AU - (IACSIT), Int. Assoc. Comput. Sci. Inf. Technol.

N1 - 會議代碼: 81050 Export Date: 31 March 2016 通訊地址: Teng, S.; Dept. of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan; 電子郵件: 1iamtengshin@yahoo.com.tw 參考文獻: (2001) The World Health Report., , http://www.who.int;, Chap 2, 4; Mayberg, H.S., Liotti, S.K., Brannan, M., McGinnis, S., Mahurin, R.K., Jerabek, P.A., Reciprocal limbic-cortical function and negative mood: Converging PET findings in depression and normal sadness (1999) Am J Psychiatry, 156, pp. 675-682; Drevets, W.C., Price, J.L., Simpson Jr., J.R., Todd, R.D., Reich, T., Vannier, M., Subgenual prefrontal cortex abnormalities in mood disorders (1997) Nature, 386, pp. 824-827; Drevets, W.C., Neuroimaging studies of mood disorders. (2000) Biol Psychiatry, 48, pp. 813-829; Sheline, Y.I., Barch, D.M., Ollinger, J.M., Donnelly, J.M., Snyder, A.Z., Mintun, M.A., Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: An fMRI study (2001) Biol Psychiatry, 50, pp. 651-658; Anand, A., Li, Y., Wang, Y., Wu, J.W., Gao, S.J., Bukhari, L.B., Mathews, V.P., Lowe, M.J., Activity and connectivity of brain mood regulating circuit in depression: A functional magnetic resonance study (2005) Biol Psychiatry, 57, pp. 1079-1088; Greicius, M.D., Flores, B.H., Menon, V., Glover, G.H., Solvason, H.B., Kenna, H., Reiss, A.L., Schatzberg, A.F., Resting-state functional connectivity in major depression: Abnormally increased contributions from subgenual cingulate cortex and thalamus (2007) Biol Psychiatry, 62, pp. 429-437; Sheline, Y.I., Barch, D.M., Price, J.L., Rundle, M.M., Vaishnavi, S.N., Snyder, A.Z., Mintun, M.A., Raichle, M.E., The default mode network and self-referential processes in depression (2009) PNAS, 106, pp. 1942-1947; Malhi, G.S., Lagopoulos, J., Owen, A.M., Ivanovski, B., Shnier, R., Sachdev, P., Reduced activation to implicit affect induction in euthymic bipolar patients: An fMRI study (2007) Journal of Affective Disorders, 97, pp. 109-122; Pavuluri, M.N., Passarotti, A.M., Harral, E.M., Sweeney, J.A., An fMRI study of the neural correlates of incidental versus directed emotion processing in pediatric bipolar disorder (2009) J. Am. Acad. Child Adolesc. Psychiatry, 48, pp. 308-319; Tzourio-Mazoyer, N., Landeau, N., Papathanassiou, B., Crivello, D., Etard, F., Delcroix, O., Mazoyer, B., Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain (2002) NeuroImage, 15, pp. 273-289; Fraser, A.M., Swinney, H.L., Independent coordinates for strange attractors from mutual information (1986) Physical Review A, 33, pp. 1134-1140; Drevets, W.C., Price, J.L., Furey, M.L., Brain structural and functional abnormalities in mood disorders: Implications for neurocircuitry models of depression (2008) Brain Struct Funct, 213, pp. 93-118; Phillips, M.L., Drevets, W.C., Rauch, S.L., Lane, R., Neurobiology of emotion perception II: Implications for major psychiatric disorders (2003) Biol Psychiatry, 54, pp. 515-528; Ongür, D., Price, J.L., The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans (2000) Cereb Cortex, 10, pp. 206-219

PY - 2010

Y1 - 2010

N2 - Major depressive disorder (MDD) is one of the most common affective disorders which ranks among the top causes of worldwide disease burden and disability. Recent studies suggested that MDD resulted in the functional connectivity alteration in the resting state brain networks, such as the emotional circuit and the default mode network (DMN). In addition to these emotion-relevant networks, some other brain regions, such as cuneus gyrus, lingual gyrus and precuneus gyrus, were reported that the activity reduced while performing cognitive tasks. In this study, we examined three networks, i.e. the emotional circuit, the default mode network, and the whole brain network, derived from resting-state functional magnetic resonance imaging (fMRI) to investigate the difference between MDD patients and normal subjects. Furthermore, we explored whether there is another network affected by MDD. The functional MRI data was acquired from 22 healthy subjects and 20 patients with MDD. All images of each subject were parcellated into 90 cortical and sub-cortical regions which were defined as the nodes of the network. The functional relations between the 90 regions were estimated by the time-frequency normalized mutual information (TFNMI). We found that the functional connectivity between any pair of brain regions within each of the three networks was significantly decreased in MDD group by using the t test. The significantly decreased connectivity for MDD in emotional circuit was found in the frontal lobe and between the frontal cortex and limbic regions, and that in DMN exhibited between the frontal cortex and superior temporal cortex. However, in the whole brain network, the most significantly decreased connectivity was revealed in occipital lobe, parietal-occipital, and frontal-occipital regions. Our findings suggested that the functional brain network affected by MDD comprised not only the frontal and limbic regions but also the parts of the parietal and occipital lobe. © 2010 IEEE.

AB - Major depressive disorder (MDD) is one of the most common affective disorders which ranks among the top causes of worldwide disease burden and disability. Recent studies suggested that MDD resulted in the functional connectivity alteration in the resting state brain networks, such as the emotional circuit and the default mode network (DMN). In addition to these emotion-relevant networks, some other brain regions, such as cuneus gyrus, lingual gyrus and precuneus gyrus, were reported that the activity reduced while performing cognitive tasks. In this study, we examined three networks, i.e. the emotional circuit, the default mode network, and the whole brain network, derived from resting-state functional magnetic resonance imaging (fMRI) to investigate the difference between MDD patients and normal subjects. Furthermore, we explored whether there is another network affected by MDD. The functional MRI data was acquired from 22 healthy subjects and 20 patients with MDD. All images of each subject were parcellated into 90 cortical and sub-cortical regions which were defined as the nodes of the network. The functional relations between the 90 regions were estimated by the time-frequency normalized mutual information (TFNMI). We found that the functional connectivity between any pair of brain regions within each of the three networks was significantly decreased in MDD group by using the t test. The significantly decreased connectivity for MDD in emotional circuit was found in the frontal lobe and between the frontal cortex and limbic regions, and that in DMN exhibited between the frontal cortex and superior temporal cortex. However, in the whole brain network, the most significantly decreased connectivity was revealed in occipital lobe, parietal-occipital, and frontal-occipital regions. Our findings suggested that the functional brain network affected by MDD comprised not only the frontal and limbic regions but also the parts of the parietal and occipital lobe. © 2010 IEEE.

KW - Functional connecitivy

KW - Functional MRI

KW - Major depressive disorder

KW - Time-frequency normalized mutual information

KW - Brain networks

KW - Brain regions

KW - Cognitive task

KW - Cortical regions

KW - Frontal cortex

KW - Frontal lobes

KW - Functional connectivity

KW - Functional magnetic resonance imaging

KW - Functional relation

KW - Healthy subjects

KW - Normalized mutual information

KW - Resting state

KW - T-tests

KW - Time frequency

KW - Bioinformatics

KW - Brain

KW - Magnetic resonance

KW - Magnetic resonance imaging

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