Investigation of antiulcer activities of imidazo[1,2-α]pyridinyl-2-alkylaminobenzoxazoles and 5,6,7,8-tetahydroimidazo[1,2-α]pyridinylbenzoxazoles with electron-topological (ET) method

Hsu Shan Huang, Jeng Fong Chiou, Hui Fen Chiu, Rong Fu Chen, Yu Liang Lai

Research output: Contribution to journalArticle

Abstract

The study presents structure-activity considerations of a series of imidazo[1,2-α]pyridiny-2-alkylaminobenzoxazoles(I) and 5,6,7,8-tetahydroimidazo[1,2-α]pyridinylbenzoxazoles (II) investigated for anti-stress ulcer activity with the electron-topological method. A series of 39 compounds including 24 active and 15 weakly active was studied. It is shown that the fragment determined by the electron-topological method in an active molecule is responsible for anti-stress ulcer activity. Quantitative structure-activity relationships with electron topological approach of these compounds are discussed in terms of the statistical program STATGRAF-7.0.

Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalArchiv der Pharmazie
Volume335
Issue number1
DOIs
Publication statusPublished - 2002

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Keywords

  • Antiulcer activity
  • Electronic structure
  • Structure-activity relationship

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

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