Inverse correlation of phospho-KDR/Flk-1 expression and stage of colorectal cancer: Implication of the significance of neoangiogenesis in activated VEGFR -2 expressing early stage colorectal adenocarcinomas

Yi Feng Lin, Chun Chao Chang, Shu Hui Lin, Chung Min Yeh, Tzu Cheng Su, Pei Ru Wu, Kun Tu Yeh, Ming Chung Jiang, Pi Yu Chen, Hui Ting Hsu

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The activation of vascular endothelial cell growth factor receptors (VEGFRs) plays an essential role in cancer progression. In this study, we investigated the expression of phosphorylated VEGFR-2 (or phospho-KDR/Flk-1), the activated form of VEGFR-2, in human colorectal adenomas and colorectal adenocarcinomas. Phospho- KDR/Flk-1 showed weak expression in the normal colorectal tissue. Phospho- KDR/Flk-1 was mainly stained in the cytoplasm of colorectal adenomas, and was stained in both the cytoplasm and nuclei colorectal adenocarcinomas. There was no indication of increased phospho-KDR/Flk-1 expression in the colorectal adenocarcinomas, as compared to that of colorectal adenomas. Furthermore, there was an inverse relationship of phospho-KDR/Flk-1 expression with cancer stage (p <0.0001), lymph node metastasis (p = 0.011), and distant metastasis (p = = 0.021) of the colorectal adenocarcinomas. Our results indicate that early stage colorectal adenocarcinomas with highly activated (phosphorylated) VEGFR-2 expression may indicate the significance of neoangiogenesis of the tumors.

Original languageEnglish
Pages (from-to)194-201
Number of pages8
JournalPolish Journal of Pathology
Volume65
Issue number3
DOIs
Publication statusPublished - Nov 1 2014

Keywords

  • Cancer stage
  • Colorectal adenocarcinoma
  • Metastasis
  • Phospho-KDR/Flk-1
  • VEGFR-2

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

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