Inverse Association between Hepatitis B Virus Infection and Fatty Liver Disease: A Large-Scale Study in Populations Seeking for Check-Up

Yuan Lung Cheng, Yuan Jen Wang, Wei Yu Kao, Ping Hsien Chen, Teh Ia Huo, Yi Hsiang Huang, Keng Hsin Lan, Chien Wei Su, Wan Leong Chan, Han Chieh Lin, Fa Yauh Lee, Jaw Ching Wu

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background:Although many studies have attempted to clarify the association between hepatitis B virus (HBV) infection and fatty liver disease, no prior studies have emphasized the relationship of HBV and fatty liver regarding different demographics of age and body mass index (BMI).Aim:To investigate the correlation of HBV and fatty liver in the different demographics of age and BMI.Methods:We enrolled consecutive subjects who had received health check-up services at the Taipei Veterans General Hospital from 2002 to 2009 and ultrasonography was used to diagnose fatty liver according to the practice guidelines of the American Gastroenterological Association.Results:Among the 33,439 subjects enrolled in this study, fatty liver was diagnosed in 43.9% of the population and 38.9% of patients with chronic HBV infection. Multivariate analysis showed that BMI, age, waist circumference, systolic blood pressure, fasting glucose, cholesterol, alanine aminotransferase (ALT) levels, and platelet counts were positively associated, while hepatitis B surface antigen (HBsAg) positivity was inversely associated with fatty liver, especially for subjects with BMI>22.4 kg/m2 and age>50 years. On the contrary, HBV infection was positively correlated with the presence of elevated serum ALT levels in subjects with fatty liver disease regardless of their age and BMI.Conclusions:Metabolic factors are important determinants for the prevalence of fatty liver. Patients with HBV infection were inversely associated with fatty liver disease than the general population, especially in older and obese patients. Furthermore, metabolic factors and HBV infection were associated with elevated serum ALT levels in fatty liver disease.

Original languageEnglish
Article numbere72049
JournalPLoS One
Volume8
Issue number8
DOIs
Publication statusPublished - Aug 22 2013

Fingerprint

Hepatitis B virus
fatty liver
liver diseases
Virus Diseases
Fatty Liver
Viruses
Liver
Liver Diseases
infection
Population
body mass index
Body Mass Index
Alanine Transaminase
alanine transaminase
demographic statistics
Demography
chronic hepatitis B
veterans
Blood Pressure
Veterans Hospitals

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Inverse Association between Hepatitis B Virus Infection and Fatty Liver Disease : A Large-Scale Study in Populations Seeking for Check-Up. / Cheng, Yuan Lung; Wang, Yuan Jen; Kao, Wei Yu; Chen, Ping Hsien; Huo, Teh Ia; Huang, Yi Hsiang; Lan, Keng Hsin; Su, Chien Wei; Chan, Wan Leong; Lin, Han Chieh; Lee, Fa Yauh; Wu, Jaw Ching.

In: PLoS One, Vol. 8, No. 8, e72049, 22.08.2013.

Research output: Contribution to journalArticle

Cheng, YL, Wang, YJ, Kao, WY, Chen, PH, Huo, TI, Huang, YH, Lan, KH, Su, CW, Chan, WL, Lin, HC, Lee, FY & Wu, JC 2013, 'Inverse Association between Hepatitis B Virus Infection and Fatty Liver Disease: A Large-Scale Study in Populations Seeking for Check-Up', PLoS One, vol. 8, no. 8, e72049. https://doi.org/10.1371/journal.pone.0072049
Cheng, Yuan Lung ; Wang, Yuan Jen ; Kao, Wei Yu ; Chen, Ping Hsien ; Huo, Teh Ia ; Huang, Yi Hsiang ; Lan, Keng Hsin ; Su, Chien Wei ; Chan, Wan Leong ; Lin, Han Chieh ; Lee, Fa Yauh ; Wu, Jaw Ching. / Inverse Association between Hepatitis B Virus Infection and Fatty Liver Disease : A Large-Scale Study in Populations Seeking for Check-Up. In: PLoS One. 2013 ; Vol. 8, No. 8.
@article{6e94112647644c24a73f83ded2cf95d1,
title = "Inverse Association between Hepatitis B Virus Infection and Fatty Liver Disease: A Large-Scale Study in Populations Seeking for Check-Up",
abstract = "Background:Although many studies have attempted to clarify the association between hepatitis B virus (HBV) infection and fatty liver disease, no prior studies have emphasized the relationship of HBV and fatty liver regarding different demographics of age and body mass index (BMI).Aim:To investigate the correlation of HBV and fatty liver in the different demographics of age and BMI.Methods:We enrolled consecutive subjects who had received health check-up services at the Taipei Veterans General Hospital from 2002 to 2009 and ultrasonography was used to diagnose fatty liver according to the practice guidelines of the American Gastroenterological Association.Results:Among the 33,439 subjects enrolled in this study, fatty liver was diagnosed in 43.9{\%} of the population and 38.9{\%} of patients with chronic HBV infection. Multivariate analysis showed that BMI, age, waist circumference, systolic blood pressure, fasting glucose, cholesterol, alanine aminotransferase (ALT) levels, and platelet counts were positively associated, while hepatitis B surface antigen (HBsAg) positivity was inversely associated with fatty liver, especially for subjects with BMI>22.4 kg/m2 and age>50 years. On the contrary, HBV infection was positively correlated with the presence of elevated serum ALT levels in subjects with fatty liver disease regardless of their age and BMI.Conclusions:Metabolic factors are important determinants for the prevalence of fatty liver. Patients with HBV infection were inversely associated with fatty liver disease than the general population, especially in older and obese patients. Furthermore, metabolic factors and HBV infection were associated with elevated serum ALT levels in fatty liver disease.",
author = "Cheng, {Yuan Lung} and Wang, {Yuan Jen} and Kao, {Wei Yu} and Chen, {Ping Hsien} and Huo, {Teh Ia} and Huang, {Yi Hsiang} and Lan, {Keng Hsin} and Su, {Chien Wei} and Chan, {Wan Leong} and Lin, {Han Chieh} and Lee, {Fa Yauh} and Wu, {Jaw Ching}",
year = "2013",
month = "8",
day = "22",
doi = "10.1371/journal.pone.0072049",
language = "English",
volume = "8",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",

}

TY - JOUR

T1 - Inverse Association between Hepatitis B Virus Infection and Fatty Liver Disease

T2 - A Large-Scale Study in Populations Seeking for Check-Up

AU - Cheng, Yuan Lung

AU - Wang, Yuan Jen

AU - Kao, Wei Yu

AU - Chen, Ping Hsien

AU - Huo, Teh Ia

AU - Huang, Yi Hsiang

AU - Lan, Keng Hsin

AU - Su, Chien Wei

AU - Chan, Wan Leong

AU - Lin, Han Chieh

AU - Lee, Fa Yauh

AU - Wu, Jaw Ching

PY - 2013/8/22

Y1 - 2013/8/22

N2 - Background:Although many studies have attempted to clarify the association between hepatitis B virus (HBV) infection and fatty liver disease, no prior studies have emphasized the relationship of HBV and fatty liver regarding different demographics of age and body mass index (BMI).Aim:To investigate the correlation of HBV and fatty liver in the different demographics of age and BMI.Methods:We enrolled consecutive subjects who had received health check-up services at the Taipei Veterans General Hospital from 2002 to 2009 and ultrasonography was used to diagnose fatty liver according to the practice guidelines of the American Gastroenterological Association.Results:Among the 33,439 subjects enrolled in this study, fatty liver was diagnosed in 43.9% of the population and 38.9% of patients with chronic HBV infection. Multivariate analysis showed that BMI, age, waist circumference, systolic blood pressure, fasting glucose, cholesterol, alanine aminotransferase (ALT) levels, and platelet counts were positively associated, while hepatitis B surface antigen (HBsAg) positivity was inversely associated with fatty liver, especially for subjects with BMI>22.4 kg/m2 and age>50 years. On the contrary, HBV infection was positively correlated with the presence of elevated serum ALT levels in subjects with fatty liver disease regardless of their age and BMI.Conclusions:Metabolic factors are important determinants for the prevalence of fatty liver. Patients with HBV infection were inversely associated with fatty liver disease than the general population, especially in older and obese patients. Furthermore, metabolic factors and HBV infection were associated with elevated serum ALT levels in fatty liver disease.

AB - Background:Although many studies have attempted to clarify the association between hepatitis B virus (HBV) infection and fatty liver disease, no prior studies have emphasized the relationship of HBV and fatty liver regarding different demographics of age and body mass index (BMI).Aim:To investigate the correlation of HBV and fatty liver in the different demographics of age and BMI.Methods:We enrolled consecutive subjects who had received health check-up services at the Taipei Veterans General Hospital from 2002 to 2009 and ultrasonography was used to diagnose fatty liver according to the practice guidelines of the American Gastroenterological Association.Results:Among the 33,439 subjects enrolled in this study, fatty liver was diagnosed in 43.9% of the population and 38.9% of patients with chronic HBV infection. Multivariate analysis showed that BMI, age, waist circumference, systolic blood pressure, fasting glucose, cholesterol, alanine aminotransferase (ALT) levels, and platelet counts were positively associated, while hepatitis B surface antigen (HBsAg) positivity was inversely associated with fatty liver, especially for subjects with BMI>22.4 kg/m2 and age>50 years. On the contrary, HBV infection was positively correlated with the presence of elevated serum ALT levels in subjects with fatty liver disease regardless of their age and BMI.Conclusions:Metabolic factors are important determinants for the prevalence of fatty liver. Patients with HBV infection were inversely associated with fatty liver disease than the general population, especially in older and obese patients. Furthermore, metabolic factors and HBV infection were associated with elevated serum ALT levels in fatty liver disease.

UR - http://www.scopus.com/inward/record.url?scp=84882753071&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882753071&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0072049

DO - 10.1371/journal.pone.0072049

M3 - Article

C2 - 23991037

AN - SCOPUS:84882753071

VL - 8

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 8

M1 - e72049

ER -