Invasive PLA microneedle fabrication applied to drug delivery system

Hsin Chuan Kuo, Yi Lin, Yung Kang Shen, Sheng Chieh Kang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

This study fabricated a novel biodegradable polymer microneedle patch. First, a master microneedle array was fabricated using the micro electro-mechainal system (MEMS) process. Polydimethylsiloxane (PDMS) was then utilized to fabricate the microneedle mold. Finally, the biodegradable polymer polylactic acid (PLA) microneedle patch was fabricated by micro hot embossing. The Taguchi method was applied to identify the optimal process parameters for micro hot embossing the PLA microneedle. The sizes of the original microneedle and that of the PLA microneedle were compared, through the transfor by PDMS mold. Next, a numerical simulation and the skin puncture test were used to confirm the PLA microneedle patch fabrication using the optimal process parameters. During numerical simulations, this study used dynamic finite element software (ANSYS/LSDYNA) to simulate the process of the PLA microneedle being inserted into skin. Based on the mechanical properties of different skin layers and the material failure criterion, insertion force and stress variation during PLA microneedle insertion into skin were determined. In a skin puncture experiment, transepidermal water loss (TEWL) was measured to determine whether the PLA microneedle damaged the stratum corneum and decreased the water protection capacity of skin.

Original languageEnglish
Title of host publication2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011 - Proceedings
Pages7437-7440
Number of pages4
DOIs
Publication statusPublished - 2011
Event2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011 - Inner Mongolia, China
Duration: Jul 15 2011Jul 17 2011

Other

Other2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011
CountryChina
CityInner Mongolia
Period7/15/117/17/11

Fingerprint

Skin
Fabrication
Acids
Biodegradable polymers
Polydimethylsiloxane
Taguchi methods
Computer simulation
Drug Delivery Systems
Water
Mechanical properties
Experiments

Keywords

  • Micro hot embossing
  • Numerical simulation
  • PLA microneedle
  • Taguchi method
  • Transepidermal water loss (TEWL)

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Mechanical Engineering

Cite this

Kuo, H. C., Lin, Y., Shen, Y. K., & Kang, S. C. (2011). Invasive PLA microneedle fabrication applied to drug delivery system. In 2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011 - Proceedings (pp. 7437-7440). [5988769] https://doi.org/10.1109/MACE.2011.5988769

Invasive PLA microneedle fabrication applied to drug delivery system. / Kuo, Hsin Chuan; Lin, Yi; Shen, Yung Kang; Kang, Sheng Chieh.

2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011 - Proceedings. 2011. p. 7437-7440 5988769.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kuo, HC, Lin, Y, Shen, YK & Kang, SC 2011, Invasive PLA microneedle fabrication applied to drug delivery system. in 2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011 - Proceedings., 5988769, pp. 7437-7440, 2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011, Inner Mongolia, China, 7/15/11. https://doi.org/10.1109/MACE.2011.5988769
Kuo HC, Lin Y, Shen YK, Kang SC. Invasive PLA microneedle fabrication applied to drug delivery system. In 2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011 - Proceedings. 2011. p. 7437-7440. 5988769 https://doi.org/10.1109/MACE.2011.5988769
Kuo, Hsin Chuan ; Lin, Yi ; Shen, Yung Kang ; Kang, Sheng Chieh. / Invasive PLA microneedle fabrication applied to drug delivery system. 2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011 - Proceedings. 2011. pp. 7437-7440
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AB - This study fabricated a novel biodegradable polymer microneedle patch. First, a master microneedle array was fabricated using the micro electro-mechainal system (MEMS) process. Polydimethylsiloxane (PDMS) was then utilized to fabricate the microneedle mold. Finally, the biodegradable polymer polylactic acid (PLA) microneedle patch was fabricated by micro hot embossing. The Taguchi method was applied to identify the optimal process parameters for micro hot embossing the PLA microneedle. The sizes of the original microneedle and that of the PLA microneedle were compared, through the transfor by PDMS mold. Next, a numerical simulation and the skin puncture test were used to confirm the PLA microneedle patch fabrication using the optimal process parameters. During numerical simulations, this study used dynamic finite element software (ANSYS/LSDYNA) to simulate the process of the PLA microneedle being inserted into skin. Based on the mechanical properties of different skin layers and the material failure criterion, insertion force and stress variation during PLA microneedle insertion into skin were determined. In a skin puncture experiment, transepidermal water loss (TEWL) was measured to determine whether the PLA microneedle damaged the stratum corneum and decreased the water protection capacity of skin.

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