Invasive pediatric Neisseria meningitidis infections

Pao Lan Tuan, Wen Chen Li, Yhu Chering Huang, Cheng Hsun Chiu, Tzou Yien Lin

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Background and purpose: Neisseria meningitidis usually causes severe infection in children, but occurs only sporadically in Taiwan. However the number of infections increased in 2001 and 2002. This study was performed to ascertain the epidemiology and clinical manifestations of infections caused by meningococcus in a pediatric population. Methods: The medical charts of patients with meningococcal diseases who were admitted to Chang Gung Children's Hospital, Taoyuan, Taiwan, from July 1998 to December 2005 were retrospectively reviewed. Data were analyzed for age distribution, serogroups, clinical diagnoses, treatment, acute complications, and outcomes. Results: Sixteen children with meningococcal disease were identified. Their ages ranged from 1 month to 15 years (average, 3 years). Most patients (62.5%) were younger than 1 year and the second most frequent age group was 6 to 15 years (18.75%). There were 56.25% boys and 43.75% girls. The identified serogroups were B (43.75%), W135 (31.25%), A (6.25%), Y (6.25%), and undetermined (12.5%). The antibiotics used in this study were ampicillin, ceftriaxone, cefotaxime, and aqueous penicillin; the mean total treatment duration was 10 days. Purpura fulminans (37.5%), disseminated intravascular coagulopathy (31.25%), respiratory failure (25.0%), and shock (25.0%) were the commonest acute complications. Most (87.5%) of the patients survived. One patient had long-term sequeias of hearing impairment and speech delay. The mortality rate was 12.5%. Conclusions: Serogroup B and W-135 were 2 predominant serogroups to cause pediatric meningococcus, and the majority of infections occurred in children younger than 1 year. Continuous surveillance and prevention of meningococcal infections are of great importance.

Original languageEnglish
Pages (from-to)427-432
Number of pages6
JournalJournal of Microbiology, Immunology and Infection
Issue number5
Publication statusPublished - Oct 2009
Externally publishedYes


  • Meningitis
  • Meningococcal
  • Neisseria meningitidis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases


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