Inulin and fibersol-2 combined have hypolipidemic effects on high cholesterol diet-induced hyperlipidemia in hamsters

Wen Ching Huang, Che Li Lin, Yi Ju Hsu, Yen Shuo Chiu, Yi Ming Chen, Ming Fang Wu, Chi Chang Huang, Ming Fu Wang, Derek J. McPhee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The resistant carbohydrates, inulin, and Fibersol-2, belong to soluble dietary fibers and are considered important prebiotics that maintain biological functions, including glucose homeostasis, lipid regulation, colon disease prevention, and prebiotics characteristics. However, few studies have investigated Fibersol-2 alone or in combination with inulin to assess a pooled effect on modulation of hyperlipidemia. We aimed to investigate the effects of this combined supplement (defined as InF) on hamsters fed a 0.2% cholesterol and 10% lard diet (i.e., high-cholesterol diet, HCD) to induce hyperlipidemia. A total of 40 male hamsters were randomly assigned to five groups (n = 8 per group) for treatment: standard diet, vehicle (control); or vehicle or InF supplementation by oral gavage at 0, 864, 1727, or 2591 mg/kg/day for eight weeks, designated HCD, InF-1X, InF-2X, and InF-3X groups, respectively. The hypolipidemic efficacy and safety of InF supplementation was assessed by serum lipid indexes, hepatic and fecal lipid content, and histology. InF supplementation significantly improved serum levels of triacylglycerol (TG) and low-density lipoprotein cholesterol (LDL-C) and the ratio of LDL-C/HDL-C after two-week treatment, and reduced serum total cholesterol (TC) levels after four-week administration. After eight-week supplementation, InF supplementation dose-dependently improved serum levels of TC, TG, HDL-C, and LDL-C; LDL-C/HDL-C ratio; and hepatic TC and TG levels. It inhibited TC absorption by feces elimination. Our study provides experiment-based evidence to support that this prebiotics remedy may be useful in preventing or treating hyperlipidemia.

Original languageEnglish
JournalMolecules
Volume21
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

Fingerprint

diets
Inulin
hamsters
cholesterol
Nutrition
Hyperlipidemias
Cricetinae
Cholesterol
Diet
Prebiotics
LDL Cholesterol
lipoproteins
Triglycerides
hardware description languages
serums
Serum
Lipids
lipids
Liver
Dietary Fiber

Keywords

  • High-cholesterol diet
  • Hypolipidemic
  • Inulin
  • Lipid-profiles
  • Resistant maltodextrin

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Inulin and fibersol-2 combined have hypolipidemic effects on high cholesterol diet-induced hyperlipidemia in hamsters. / Huang, Wen Ching; Lin, Che Li; Hsu, Yi Ju; Chiu, Yen Shuo; Chen, Yi Ming; Wu, Ming Fang; Huang, Chi Chang; Wang, Ming Fu; McPhee, Derek J.

In: Molecules, Vol. 21, No. 3, 01.03.2016.

Research output: Contribution to journalArticle

Huang, Wen Ching ; Lin, Che Li ; Hsu, Yi Ju ; Chiu, Yen Shuo ; Chen, Yi Ming ; Wu, Ming Fang ; Huang, Chi Chang ; Wang, Ming Fu ; McPhee, Derek J. / Inulin and fibersol-2 combined have hypolipidemic effects on high cholesterol diet-induced hyperlipidemia in hamsters. In: Molecules. 2016 ; Vol. 21, No. 3.
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abstract = "The resistant carbohydrates, inulin, and Fibersol-2, belong to soluble dietary fibers and are considered important prebiotics that maintain biological functions, including glucose homeostasis, lipid regulation, colon disease prevention, and prebiotics characteristics. However, few studies have investigated Fibersol-2 alone or in combination with inulin to assess a pooled effect on modulation of hyperlipidemia. We aimed to investigate the effects of this combined supplement (defined as InF) on hamsters fed a 0.2{\%} cholesterol and 10{\%} lard diet (i.e., high-cholesterol diet, HCD) to induce hyperlipidemia. A total of 40 male hamsters were randomly assigned to five groups (n = 8 per group) for treatment: standard diet, vehicle (control); or vehicle or InF supplementation by oral gavage at 0, 864, 1727, or 2591 mg/kg/day for eight weeks, designated HCD, InF-1X, InF-2X, and InF-3X groups, respectively. The hypolipidemic efficacy and safety of InF supplementation was assessed by serum lipid indexes, hepatic and fecal lipid content, and histology. InF supplementation significantly improved serum levels of triacylglycerol (TG) and low-density lipoprotein cholesterol (LDL-C) and the ratio of LDL-C/HDL-C after two-week treatment, and reduced serum total cholesterol (TC) levels after four-week administration. After eight-week supplementation, InF supplementation dose-dependently improved serum levels of TC, TG, HDL-C, and LDL-C; LDL-C/HDL-C ratio; and hepatic TC and TG levels. It inhibited TC absorption by feces elimination. Our study provides experiment-based evidence to support that this prebiotics remedy may be useful in preventing or treating hyperlipidemia.",
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AU - Chiu, Yen Shuo

AU - Chen, Yi Ming

AU - Wu, Ming Fang

AU - Huang, Chi Chang

AU - Wang, Ming Fu

AU - McPhee, Derek J.

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