Intravenous sotalol decreases transthoracic cardioversion energy requirement for chronic atrial fibrillation in humans: Assessment of the electrophysiological effects by biatrial basket electrodes

Ling Ping Lai, Jiunn Lee Lin, Wen Pin Lien, Yung Zu Tseng, Shoei K Stephen Huang

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Objectives. This study was undertaken to assess the effects of sotalol on the transthoracic cardioversion energy requirement for chronic atrial fibrillation (AF) and on the atrial electrograms during AF recorded by two basket electrodes. Background. The effects of sotalol infusion on transthoracic electrical cardioversion for chronic atrial fibrillation in humans have not been well investigated. Methods. We included 18 patients with persistent AF for more than three months. Atrial electrograms were recorded by two basket electrodes positioned in each atrium respectively. Transthoracic cardioversion was performed before and after sotalol 1.5 mg/kg IV infusion. Results. In the 14 patients whose AF could be terminated by cardioversion before sotalol infusion, the atrial defibrillation energy was significantly reduced after sotalol infusion (236 ± 74 jules [J] vs. 186 ± 77 J; p < 0.01). Atrial fibrillation was refractory to cardioversion in four patients at baseline and was converted to sinus rhythm by cardioversion after sotalol infusion in two of them. We further divided the patients into two groups. Group A consisted of 10 patients in whom the energy requirement was decreased by sotalol while group B consisted of eight patients in whom the energy requirement was not decreased. The mean A-A (atrial local electrogram) intervals during AF were significantly increased after sotalol infusion in both groups, but the increment of A-A interval was significantly larger in group A than it was in group B patients (36 ± 13 ms vs. 22 ± 8 ms for the right atrium; 19 ± 7 ms vs. 9 ± 7 ms for the left atrium; both p < 0.05). The spatial and temporal dispersions of A-A intervals were not significantly changed after sotalol infusion in both atria in both groups. Conclusions. Sotalol decreases the atrial defibrillation energy requirement by increasing atrial refractoriness but not by decreasing the dispersion of refractoriness. (C) 2000 by the American College of Cardiology.

Original languageEnglish
Pages (from-to)1434-1441
Number of pages8
JournalJournal of the American College of Cardiology
Volume35
Issue number6
DOIs
Publication statusPublished - May 1 2000
Externally publishedYes

Fingerprint

Sotalol
Electric Countershock
Atrial Fibrillation
Electrodes
Cardiac Electrophysiologic Techniques
Heart Atria

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Intravenous sotalol decreases transthoracic cardioversion energy requirement for chronic atrial fibrillation in humans : Assessment of the electrophysiological effects by biatrial basket electrodes. / Lai, Ling Ping; Lin, Jiunn Lee; Lien, Wen Pin; Tseng, Yung Zu; Huang, Shoei K Stephen.

In: Journal of the American College of Cardiology, Vol. 35, No. 6, 01.05.2000, p. 1434-1441.

Research output: Contribution to journalArticle

@article{41e417eec5844d67a4e0cbdc82bd0304,
title = "Intravenous sotalol decreases transthoracic cardioversion energy requirement for chronic atrial fibrillation in humans: Assessment of the electrophysiological effects by biatrial basket electrodes",
abstract = "Objectives. This study was undertaken to assess the effects of sotalol on the transthoracic cardioversion energy requirement for chronic atrial fibrillation (AF) and on the atrial electrograms during AF recorded by two basket electrodes. Background. The effects of sotalol infusion on transthoracic electrical cardioversion for chronic atrial fibrillation in humans have not been well investigated. Methods. We included 18 patients with persistent AF for more than three months. Atrial electrograms were recorded by two basket electrodes positioned in each atrium respectively. Transthoracic cardioversion was performed before and after sotalol 1.5 mg/kg IV infusion. Results. In the 14 patients whose AF could be terminated by cardioversion before sotalol infusion, the atrial defibrillation energy was significantly reduced after sotalol infusion (236 ± 74 jules [J] vs. 186 ± 77 J; p < 0.01). Atrial fibrillation was refractory to cardioversion in four patients at baseline and was converted to sinus rhythm by cardioversion after sotalol infusion in two of them. We further divided the patients into two groups. Group A consisted of 10 patients in whom the energy requirement was decreased by sotalol while group B consisted of eight patients in whom the energy requirement was not decreased. The mean A-A (atrial local electrogram) intervals during AF were significantly increased after sotalol infusion in both groups, but the increment of A-A interval was significantly larger in group A than it was in group B patients (36 ± 13 ms vs. 22 ± 8 ms for the right atrium; 19 ± 7 ms vs. 9 ± 7 ms for the left atrium; both p < 0.05). The spatial and temporal dispersions of A-A intervals were not significantly changed after sotalol infusion in both atria in both groups. Conclusions. Sotalol decreases the atrial defibrillation energy requirement by increasing atrial refractoriness but not by decreasing the dispersion of refractoriness. (C) 2000 by the American College of Cardiology.",
author = "Lai, {Ling Ping} and Lin, {Jiunn Lee} and Lien, {Wen Pin} and Tseng, {Yung Zu} and Huang, {Shoei K Stephen}",
year = "2000",
month = "5",
day = "1",
doi = "10.1016/S0735-1097(00)00597-0",
language = "English",
volume = "35",
pages = "1434--1441",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "6",

}

TY - JOUR

T1 - Intravenous sotalol decreases transthoracic cardioversion energy requirement for chronic atrial fibrillation in humans

T2 - Assessment of the electrophysiological effects by biatrial basket electrodes

AU - Lai, Ling Ping

AU - Lin, Jiunn Lee

AU - Lien, Wen Pin

AU - Tseng, Yung Zu

AU - Huang, Shoei K Stephen

PY - 2000/5/1

Y1 - 2000/5/1

N2 - Objectives. This study was undertaken to assess the effects of sotalol on the transthoracic cardioversion energy requirement for chronic atrial fibrillation (AF) and on the atrial electrograms during AF recorded by two basket electrodes. Background. The effects of sotalol infusion on transthoracic electrical cardioversion for chronic atrial fibrillation in humans have not been well investigated. Methods. We included 18 patients with persistent AF for more than three months. Atrial electrograms were recorded by two basket electrodes positioned in each atrium respectively. Transthoracic cardioversion was performed before and after sotalol 1.5 mg/kg IV infusion. Results. In the 14 patients whose AF could be terminated by cardioversion before sotalol infusion, the atrial defibrillation energy was significantly reduced after sotalol infusion (236 ± 74 jules [J] vs. 186 ± 77 J; p < 0.01). Atrial fibrillation was refractory to cardioversion in four patients at baseline and was converted to sinus rhythm by cardioversion after sotalol infusion in two of them. We further divided the patients into two groups. Group A consisted of 10 patients in whom the energy requirement was decreased by sotalol while group B consisted of eight patients in whom the energy requirement was not decreased. The mean A-A (atrial local electrogram) intervals during AF were significantly increased after sotalol infusion in both groups, but the increment of A-A interval was significantly larger in group A than it was in group B patients (36 ± 13 ms vs. 22 ± 8 ms for the right atrium; 19 ± 7 ms vs. 9 ± 7 ms for the left atrium; both p < 0.05). The spatial and temporal dispersions of A-A intervals were not significantly changed after sotalol infusion in both atria in both groups. Conclusions. Sotalol decreases the atrial defibrillation energy requirement by increasing atrial refractoriness but not by decreasing the dispersion of refractoriness. (C) 2000 by the American College of Cardiology.

AB - Objectives. This study was undertaken to assess the effects of sotalol on the transthoracic cardioversion energy requirement for chronic atrial fibrillation (AF) and on the atrial electrograms during AF recorded by two basket electrodes. Background. The effects of sotalol infusion on transthoracic electrical cardioversion for chronic atrial fibrillation in humans have not been well investigated. Methods. We included 18 patients with persistent AF for more than three months. Atrial electrograms were recorded by two basket electrodes positioned in each atrium respectively. Transthoracic cardioversion was performed before and after sotalol 1.5 mg/kg IV infusion. Results. In the 14 patients whose AF could be terminated by cardioversion before sotalol infusion, the atrial defibrillation energy was significantly reduced after sotalol infusion (236 ± 74 jules [J] vs. 186 ± 77 J; p < 0.01). Atrial fibrillation was refractory to cardioversion in four patients at baseline and was converted to sinus rhythm by cardioversion after sotalol infusion in two of them. We further divided the patients into two groups. Group A consisted of 10 patients in whom the energy requirement was decreased by sotalol while group B consisted of eight patients in whom the energy requirement was not decreased. The mean A-A (atrial local electrogram) intervals during AF were significantly increased after sotalol infusion in both groups, but the increment of A-A interval was significantly larger in group A than it was in group B patients (36 ± 13 ms vs. 22 ± 8 ms for the right atrium; 19 ± 7 ms vs. 9 ± 7 ms for the left atrium; both p < 0.05). The spatial and temporal dispersions of A-A intervals were not significantly changed after sotalol infusion in both atria in both groups. Conclusions. Sotalol decreases the atrial defibrillation energy requirement by increasing atrial refractoriness but not by decreasing the dispersion of refractoriness. (C) 2000 by the American College of Cardiology.

UR - http://www.scopus.com/inward/record.url?scp=0034025980&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034025980&partnerID=8YFLogxK

U2 - 10.1016/S0735-1097(00)00597-0

DO - 10.1016/S0735-1097(00)00597-0

M3 - Article

C2 - 10807444

AN - SCOPUS:0034025980

VL - 35

SP - 1434

EP - 1441

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 6

ER -