Intravenous morphine reduces plasma endothelin 1 concentration through activation of neutral endopeptidase 24.11 in patients with myocardial infarction

Tzong Luen Wang, Hang Chang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Study objective: Morphine has multiple cardiovascular effects, but its action on hydrolysis of endothelin 1 (ET-1) has not been investigated. Methods: We measured plasma levels of ET-1, C-terminal degradation products of ET-1, and neutral endopeptidase 24.11 (NEP) in 68 patients with acute Q-wave myocardial infarction and 29 control subjects. All the patients underwent blood sampling at initial presentation and 10 minutes later. Thirty-six of those with Q-wave myocardial infarction intravenously received 3 mg of morphine immediately after the first sampling (group 1), and the other 32 received the same after the second sampling (group 2). Twenty-four of the control subjects (group 3) were randomized to the protocol of group 1, and the remaining 5 subjects (group 4) were randomized to the protocol of group 2. Results: The plasma ET-1 levels were significantly higher in groups 1 and 2 than in groups 3 and 4 (control groups). In group 1, the ET-1 level decreased significantly at second blood samplings (2.5±0.4 pmol/L versus 1.7±0.6 pmol/L, P

Original languageEnglish
Pages (from-to)445-449
Number of pages5
JournalAnnals of Emergency Medicine
Volume37
Issue number5
DOIs
Publication statusPublished - 2001
Externally publishedYes

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Neprilysin
Endothelin-1
Morphine
Myocardial Infarction
Control Groups
Hydrolysis

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

Intravenous morphine reduces plasma endothelin 1 concentration through activation of neutral endopeptidase 24.11 in patients with myocardial infarction. / Wang, Tzong Luen; Chang, Hang.

In: Annals of Emergency Medicine, Vol. 37, No. 5, 2001, p. 445-449.

Research output: Contribution to journalArticle

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abstract = "Study objective: Morphine has multiple cardiovascular effects, but its action on hydrolysis of endothelin 1 (ET-1) has not been investigated. Methods: We measured plasma levels of ET-1, C-terminal degradation products of ET-1, and neutral endopeptidase 24.11 (NEP) in 68 patients with acute Q-wave myocardial infarction and 29 control subjects. All the patients underwent blood sampling at initial presentation and 10 minutes later. Thirty-six of those with Q-wave myocardial infarction intravenously received 3 mg of morphine immediately after the first sampling (group 1), and the other 32 received the same after the second sampling (group 2). Twenty-four of the control subjects (group 3) were randomized to the protocol of group 1, and the remaining 5 subjects (group 4) were randomized to the protocol of group 2. Results: The plasma ET-1 levels were significantly higher in groups 1 and 2 than in groups 3 and 4 (control groups). In group 1, the ET-1 level decreased significantly at second blood samplings (2.5±0.4 pmol/L versus 1.7±0.6 pmol/L, P",
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