Abstract

Kawasaki disease (KD) is a systemic vasculitis of unknown etiology and it is therefore worth examining the multifactorial interaction of genes and environmental factors. Targeted genetic association and genome-wide association studies have helped to provide a better understanding of KD from infection to the immune-related response. Findings in the past decade have contributed to a major breakthrough in the genetics of KD, with the identification of several genomic regions linked to the pathogenesis of KD, including ITPKC, CD40, BLK, and FCGR2A. This review focuses on the factors associated with the genetic polymorphisms of KD and the pharmacogenomics of the response to treatment in patients with intravenous immunoglobulin resistance.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalJournal of Microbiology, Immunology and Infection
Volume49
Issue number1
DOIs
Publication statusPublished - Feb 1 2016

Keywords

  • Genetic polymorphisms
  • Genome-wide association studies
  • Intravenous immunoglobulin resistance
  • Kawasaki disease
  • Pharmacogenomics

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Infectious Diseases

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