Intravenous amiodarone for prevention of atrial fibrillation after coronary artery bypass grafting

Shih Huang Lee, Che Ming Chang, Ming Jen Lu, Ren Jen Lee, Jun Jack Cheng, Chi Ren Hung, Shih Ann Chen

Research output: Contribution to journalArticlepeer-review

90 Citations (Scopus)

Abstract

Background. Atrial fibrillation occurs in 10% to 40% of patients who undergo coronary artery bypass grafting. This prospective study assesses the safety and efficacy of low-dose intravenous amiodarone in the prevention of atrial fibrillation after coronary artery bypass grafting. Methods. One hundred forty patients were randomly divided into two groups: an amiodarone group (n = 74) receiving intravenous amiodarone in a loading dose of 150 mg and maintenance dose of 0.4 mg·kg-1·h-1 for 3 days before and 5 days after operation and a control group (n = 76) receiving matching infusions of 5% glucose solution. Results. Atrial fibrillation occurred in 9 (12%) of the amiodarone group patients and in 26 (34%) of the control group patients during hospitalization (p < 0.01). The maximum ventricular rate during atrial fibrillation was significantly slower in the amiodarone group (107 ± 21) than in the control group (138 ± 24 beats per minute, p < 0.01). The duration of atrial fibrillation in the amiodarone group (1.1 ± 1.2 hours) was significantly shorter than that in the control group (3.2 ± 1.3 hours, p = 0.01). The two groups had no significant differences in incidence of major morbidity (8 of 74 versus 8 of 76 in amiodarone and control groups, respectively) or mortality (4 of 74 versus 5 of 76). However, the control group had significantly longer intensive care unit stays (132 ± 24 versus 111 ± 19 hours, p < 0.01). Conclusions. Perioperative low-dose intravenous amiodarone significantly reduces the incidence, ventricular rate, and duration of atrial fibrillation after coronary artery bypass grafting. Furthermore, low-dose intravenous amiodarone is well tolerated and does not increase the risk of intraoperative or postoperative complications. (C) 2000 by The Society of Thoracic Surgeons.

Original languageEnglish
Pages (from-to)157-161
Number of pages5
JournalAnnals of Thoracic Surgery
Volume70
Issue number1
DOIs
Publication statusPublished - Jul 2000
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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