Intraocular Pressure Elevation After Intravitreal Triamcinolone Acetonide Injection in a Chinese Population

Ling Ing Lau, Kuan Chieh Chen, Fenq Lih Lee, Shih Jen Chen, Yu Chieh Ko, Catherine Jui-Ling Liu, Wen-Ming Hsu

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Abstract

Purpose: To study the prevalence and risk factors of intraocular pressure (IOP) elevation and refractory IOP elevation after a single 4 mg intravitreal triamcinolone acetonide (IVTA) injection in a Chinese population. Design: Retrospective, observational case series. Methods: Retrospective chart review of all the patients who received an IVTA injection at one medical center from January 2003 through June 2005. A postoperative IOP increase of more than 6 mm Hg was defined as an IOP elevation. Postoperative IOP elevation that could not be controlled by glaucoma medications was defined as refractory IOP elevation. Results: Sixty-four (43.5%) of the 147 enrolled patients experienced IOP elevation. Males had a higher risk of IOP elevation, with an odds ratio (OR) of 3.17 (95% confidence interval [CI], 1.38 to 7.27; P = .006), after adjusting for age, glaucoma history, and diagnosis of retinal disease. Patients 55 years of age and younger had a larger magnitude of IOP elevation than those older than 55 years (11.2 ± 10.1 mm Hg vs 7.3 ± 7.7 mm Hg; P = .020). Ten patients (6.8%) had refractory IOP elevation, and those 55 years of age or younger had a higher risk of refractory IOP elevation compared with those older than 55 years, with an OR of 8.16 (95% CI, 1.67 to 39.81; P = .009), after adjusting for preoperative IOP and diagnosis of retinal disease. Conclusions: Elevated IOP after IVTA injection is common in this Chinese population. Male patients have a higher risk of IOP elevation. Younger patients should be monitored carefully after IVTA injection because they exhibit a greater magnitude of IOP elevation and have an increased chance of developing refractory IOP elevation.

Original languageEnglish
JournalAmerican Journal of Ophthalmology
Volume146
Issue number4
DOIs
Publication statusPublished - Oct 1 2008

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Triamcinolone Acetonide
Intraocular Pressure
Injections
Population
Retinal Diseases
Glaucoma
Odds Ratio
Confidence Intervals

ASJC Scopus subject areas

  • Ophthalmology

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Intraocular Pressure Elevation After Intravitreal Triamcinolone Acetonide Injection in a Chinese Population. / Lau, Ling Ing; Chen, Kuan Chieh; Lee, Fenq Lih; Chen, Shih Jen; Ko, Yu Chieh; Jui-Ling Liu, Catherine; Hsu, Wen-Ming.

In: American Journal of Ophthalmology, Vol. 146, No. 4, 01.10.2008.

Research output: Contribution to journalArticle

Lau, Ling Ing ; Chen, Kuan Chieh ; Lee, Fenq Lih ; Chen, Shih Jen ; Ko, Yu Chieh ; Jui-Ling Liu, Catherine ; Hsu, Wen-Ming. / Intraocular Pressure Elevation After Intravitreal Triamcinolone Acetonide Injection in a Chinese Population. In: American Journal of Ophthalmology. 2008 ; Vol. 146, No. 4.
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abstract = "Purpose: To study the prevalence and risk factors of intraocular pressure (IOP) elevation and refractory IOP elevation after a single 4 mg intravitreal triamcinolone acetonide (IVTA) injection in a Chinese population. Design: Retrospective, observational case series. Methods: Retrospective chart review of all the patients who received an IVTA injection at one medical center from January 2003 through June 2005. A postoperative IOP increase of more than 6 mm Hg was defined as an IOP elevation. Postoperative IOP elevation that could not be controlled by glaucoma medications was defined as refractory IOP elevation. Results: Sixty-four (43.5{\%}) of the 147 enrolled patients experienced IOP elevation. Males had a higher risk of IOP elevation, with an odds ratio (OR) of 3.17 (95{\%} confidence interval [CI], 1.38 to 7.27; P = .006), after adjusting for age, glaucoma history, and diagnosis of retinal disease. Patients 55 years of age and younger had a larger magnitude of IOP elevation than those older than 55 years (11.2 ± 10.1 mm Hg vs 7.3 ± 7.7 mm Hg; P = .020). Ten patients (6.8{\%}) had refractory IOP elevation, and those 55 years of age or younger had a higher risk of refractory IOP elevation compared with those older than 55 years, with an OR of 8.16 (95{\%} CI, 1.67 to 39.81; P = .009), after adjusting for preoperative IOP and diagnosis of retinal disease. Conclusions: Elevated IOP after IVTA injection is common in this Chinese population. Male patients have a higher risk of IOP elevation. Younger patients should be monitored carefully after IVTA injection because they exhibit a greater magnitude of IOP elevation and have an increased chance of developing refractory IOP elevation.",
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AB - Purpose: To study the prevalence and risk factors of intraocular pressure (IOP) elevation and refractory IOP elevation after a single 4 mg intravitreal triamcinolone acetonide (IVTA) injection in a Chinese population. Design: Retrospective, observational case series. Methods: Retrospective chart review of all the patients who received an IVTA injection at one medical center from January 2003 through June 2005. A postoperative IOP increase of more than 6 mm Hg was defined as an IOP elevation. Postoperative IOP elevation that could not be controlled by glaucoma medications was defined as refractory IOP elevation. Results: Sixty-four (43.5%) of the 147 enrolled patients experienced IOP elevation. Males had a higher risk of IOP elevation, with an odds ratio (OR) of 3.17 (95% confidence interval [CI], 1.38 to 7.27; P = .006), after adjusting for age, glaucoma history, and diagnosis of retinal disease. Patients 55 years of age and younger had a larger magnitude of IOP elevation than those older than 55 years (11.2 ± 10.1 mm Hg vs 7.3 ± 7.7 mm Hg; P = .020). Ten patients (6.8%) had refractory IOP elevation, and those 55 years of age or younger had a higher risk of refractory IOP elevation compared with those older than 55 years, with an OR of 8.16 (95% CI, 1.67 to 39.81; P = .009), after adjusting for preoperative IOP and diagnosis of retinal disease. Conclusions: Elevated IOP after IVTA injection is common in this Chinese population. Male patients have a higher risk of IOP elevation. Younger patients should be monitored carefully after IVTA injection because they exhibit a greater magnitude of IOP elevation and have an increased chance of developing refractory IOP elevation.

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