Intralymphatic Spread is a Rare Finding Associated with Poor Prognosis in Diffuse Large B-Cell Lymphoma with Extranodal Involvements

Chieh Lung Cheng, Yung Cheng Su, Tsu Yi Chao, Chung Wu Lin, Sheng Chieh Chou, Ming Yao, Sung Hsin Kuo, Shan Chi Yu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Intralymphatic spread is common in solid cancers, but has been rarely studied in lymphomas. Review of 635 extranodal specimens from 475 diffuse large B-cell lymphoma (DLBCL) patients revealed intralymphatic spread in 10 surgical resection specimens from 10 patients including 9 de novo DLBCLs and 1 Richter transformation. The prevalence in de novo DLBCL with extranodal involvements was 1.65%. The most common involved site of intralymphatic spread was the gastrointestinal tract, followed by the female genital tract and breasts. Lymphatic vessels, lined by D2-40-positive endothelial cells, were expanded by lymphoma cells, reminiscent of intravascular lymphoma or tumor emboli. None of the involved lymphatic vessels were located in the mucosa. Patients with intralymphatic spread had a trend of lower overall response rate and a trend of higher progressive disease than those without intralymphatic spread. Compared with patients without intralymphatic spread, those patients with intralymphatic spread had a shorter median overall survival (14.3 vs. 96.2 mo; P=0.004) and a shorter median progression-free survival (11.2 vs. 64.2 mo; P=0.01), respectively. Multivariate analyses showed that intralymphatic spread was an independent poor prognostic factor for overall survival (hazard ratio, 3.029; 95% confidence interval, 1.315-6.978; P=0.009), irrespective of the National Comprehensive Cancer Network-International Prognostic Index, B symptoms, and serum albumin levels. Among patients who underwent surgical resection, intralymphatic spread was still an independent prognostic factor. In conclusion, our study demonstrated extranodal intralymphatic spread in DLBCL. Inspiringly, this rare morphologic finding may serve as a new negative prognostic indicator in DLBCL with extranodal involvements.

Original languageEnglish
Pages (from-to)616-624
Number of pages9
JournalAmerican Journal of Surgical Pathology
Volume42
Issue number5
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Lymphoma, Large B-Cell, Diffuse
Lymphoma
Lymphatic Vessels
Neoplasms
Survival
Embolism
Serum Albumin
Disease-Free Survival
Gastrointestinal Tract
Mucous Membrane
Breast
Multivariate Analysis
Endothelial Cells
Confidence Intervals

Keywords

  • diffuse large B-cell lymphoma
  • extranodal
  • intralymphatic spread
  • prognosis

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Intralymphatic Spread is a Rare Finding Associated with Poor Prognosis in Diffuse Large B-Cell Lymphoma with Extranodal Involvements. / Cheng, Chieh Lung; Su, Yung Cheng; Chao, Tsu Yi; Lin, Chung Wu; Chou, Sheng Chieh; Yao, Ming; Kuo, Sung Hsin; Yu, Shan Chi.

In: American Journal of Surgical Pathology, Vol. 42, No. 5, 01.01.2018, p. 616-624.

Research output: Contribution to journalArticle

Cheng, Chieh Lung ; Su, Yung Cheng ; Chao, Tsu Yi ; Lin, Chung Wu ; Chou, Sheng Chieh ; Yao, Ming ; Kuo, Sung Hsin ; Yu, Shan Chi. / Intralymphatic Spread is a Rare Finding Associated with Poor Prognosis in Diffuse Large B-Cell Lymphoma with Extranodal Involvements. In: American Journal of Surgical Pathology. 2018 ; Vol. 42, No. 5. pp. 616-624.
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