Intrahepatic cholangiocarcinoma and hepatitis: Case study and literature review

Frank Luh, Andrew Kuei, Patricia Fann, Peiguo Chu, Yen Yen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cholangiocarcinoma is the second most common primary malignant tumor in the liver. It is a tumor that is characteristically composed of cells resembling those from the bile duct. The disease is difficult to diagnose and is usually fatal due to its late clinical presentation, lack of effective non-operative therapy, and rapid turnover. Most patients have unresectable tumors at the time of presentation and die within 12 months once diagnosis has been made. Prognosis of intrahepatic cholangiocarcinoma (ICC) remains very poor. Currently, there is no established therapy once diagnosis is made. In this report, we provide a case of a patient who presented with ICC and positive history of hepatitis C virus (HCV). The patient also had a strong family history of cancer. Finally, we attempt to review some of the important developments in the study of ICC, with particular attention to recent studies linking hepatitis with the disease.

Original languageEnglish
Pages (from-to)3239-3243
Number of pages5
JournalAnticancer Research
Volume29
Issue number8
Publication statusPublished - Aug 1 2009
Externally publishedYes

Keywords

  • Chronic disease
  • Hepatitis C
  • ICC

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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