Intractable chronic motor tics dramatically respond to clerodendrum inerme (L) gaertn

Pi Chuan Fan, Wei Jan Huang, Lih Chu Chiou

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Tics are characterized by involuntary, sudden, rapid, repetitive, nonrhythmic, stereotyped movements or phonic productions. Those who suffer from either motor or phonic tics, but not both, for more than 1 year are diagnosed with chronic tic disorder. Several pharmacological interventions have been proposed for the treatment of tic disorder. Dopamine D2 receptor blockers and dopamine depletors are thought to be the most effective ones clinically. However, such treatments are suboptimal in terms of effectiveness and side effects, such as body weight gain and extrapyramidal symptoms. We report on a 13-year-old girl, with chronic motor tic disorder refractory to multiple anti-tic therapies, who showed dramatic improvement and remission after taking the crude leaf extract of Clerodendrum inerme (L) Gaertn. No side effects were observed during a follow-up of more than 2 years. To the best of our knowledge, this is the first report on the anti-tic effect of Clerodendrum inerme.

Original languageEnglish
Pages (from-to)887-890
Number of pages4
JournalJournal of Child Neurology
Volume24
Issue number7
DOIs
Publication statusPublished - 2009

Fingerprint

Clerodendrum
Tics
Tic Disorders
Dopamine Antagonists
Dopamine D2 Receptors
Complex Mixtures
Weight Gain
Therapeutics
Body Weight
Pharmacology
Chronic Motor Tics

Keywords

  • Chronic motor tics
  • Clerodendrum inerme
  • Herb therapy

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Intractable chronic motor tics dramatically respond to clerodendrum inerme (L) gaertn. / Fan, Pi Chuan; Huang, Wei Jan; Chiou, Lih Chu.

In: Journal of Child Neurology, Vol. 24, No. 7, 2009, p. 887-890.

Research output: Contribution to journalArticle

@article{2cac36dca9044c55a488bf9ad1c1d8c8,
title = "Intractable chronic motor tics dramatically respond to clerodendrum inerme (L) gaertn",
abstract = "Tics are characterized by involuntary, sudden, rapid, repetitive, nonrhythmic, stereotyped movements or phonic productions. Those who suffer from either motor or phonic tics, but not both, for more than 1 year are diagnosed with chronic tic disorder. Several pharmacological interventions have been proposed for the treatment of tic disorder. Dopamine D2 receptor blockers and dopamine depletors are thought to be the most effective ones clinically. However, such treatments are suboptimal in terms of effectiveness and side effects, such as body weight gain and extrapyramidal symptoms. We report on a 13-year-old girl, with chronic motor tic disorder refractory to multiple anti-tic therapies, who showed dramatic improvement and remission after taking the crude leaf extract of Clerodendrum inerme (L) Gaertn. No side effects were observed during a follow-up of more than 2 years. To the best of our knowledge, this is the first report on the anti-tic effect of Clerodendrum inerme.",
keywords = "Chronic motor tics, Clerodendrum inerme, Herb therapy",
author = "Fan, {Pi Chuan} and Huang, {Wei Jan} and Chiou, {Lih Chu}",
year = "2009",
doi = "10.1177/0883073808331088",
language = "English",
volume = "24",
pages = "887--890",
journal = "Journal of Child Neurology",
issn = "0883-0738",
publisher = "SAGE Publications Inc.",
number = "7",

}

TY - JOUR

T1 - Intractable chronic motor tics dramatically respond to clerodendrum inerme (L) gaertn

AU - Fan, Pi Chuan

AU - Huang, Wei Jan

AU - Chiou, Lih Chu

PY - 2009

Y1 - 2009

N2 - Tics are characterized by involuntary, sudden, rapid, repetitive, nonrhythmic, stereotyped movements or phonic productions. Those who suffer from either motor or phonic tics, but not both, for more than 1 year are diagnosed with chronic tic disorder. Several pharmacological interventions have been proposed for the treatment of tic disorder. Dopamine D2 receptor blockers and dopamine depletors are thought to be the most effective ones clinically. However, such treatments are suboptimal in terms of effectiveness and side effects, such as body weight gain and extrapyramidal symptoms. We report on a 13-year-old girl, with chronic motor tic disorder refractory to multiple anti-tic therapies, who showed dramatic improvement and remission after taking the crude leaf extract of Clerodendrum inerme (L) Gaertn. No side effects were observed during a follow-up of more than 2 years. To the best of our knowledge, this is the first report on the anti-tic effect of Clerodendrum inerme.

AB - Tics are characterized by involuntary, sudden, rapid, repetitive, nonrhythmic, stereotyped movements or phonic productions. Those who suffer from either motor or phonic tics, but not both, for more than 1 year are diagnosed with chronic tic disorder. Several pharmacological interventions have been proposed for the treatment of tic disorder. Dopamine D2 receptor blockers and dopamine depletors are thought to be the most effective ones clinically. However, such treatments are suboptimal in terms of effectiveness and side effects, such as body weight gain and extrapyramidal symptoms. We report on a 13-year-old girl, with chronic motor tic disorder refractory to multiple anti-tic therapies, who showed dramatic improvement and remission after taking the crude leaf extract of Clerodendrum inerme (L) Gaertn. No side effects were observed during a follow-up of more than 2 years. To the best of our knowledge, this is the first report on the anti-tic effect of Clerodendrum inerme.

KW - Chronic motor tics

KW - Clerodendrum inerme

KW - Herb therapy

UR - http://www.scopus.com/inward/record.url?scp=67949111184&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67949111184&partnerID=8YFLogxK

U2 - 10.1177/0883073808331088

DO - 10.1177/0883073808331088

M3 - Article

C2 - 19617461

AN - SCOPUS:67949111184

VL - 24

SP - 887

EP - 890

JO - Journal of Child Neurology

JF - Journal of Child Neurology

SN - 0883-0738

IS - 7

ER -