Intracellular pH-responsive mesoporous silica nanoparticles for the controlled release of anticancer chemotherapeutics

Chia Hung Lee, Shih Hsun Cheng, I. Ping Huang, Jeffrey S. Souris, Chung Shi Yang, Chung Yuan Mou, Leu Wei Lo

Research output: Contribution to journalArticlepeer-review

296 Citations (Scopus)

Abstract

Cut here to cure: Doxorubicin attached to pH-sensitive mesoporous silica nanoparticles (MSN-hydrazone-Dox) shows potential in the chemotherapeutic treatment of liver cancer. Hydrolysis of the pH-sensitive hydrazone bond in the acidic environment of endosomes/lysosomes (see picture) releases Dox intracellularly from the MSN nanochannels, resulting in highly efficient apoptotic cell death.

Original languageEnglish
Pages (from-to)8214-8219
Number of pages6
JournalAngewandte Chemie - International Edition
Volume49
Issue number44
DOIs
Publication statusPublished - Oct 25 2010
Externally publishedYes

Keywords

  • Antitumor agents
  • Apoptosis
  • Controlled release
  • Doxorubicin
  • Mesoporous silica

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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