Intra-articular injection of hyaluronate and indomethacin in rabbits with antigen-induced arthritis

Yow Jen Lo; Ming Thau Sheu; Wen Chi Tsai; Yun Ho Lin; Jau Le Li; Yu Chih Liang; Chi Ching Chang; Ming-Shium Hsieh; Chien Ho Chen

doi:10.1007/s00296-007-0346-1

Intra-articular injection of hyaluronate and indomethacin in rabbits with antigen-induced arthritis

Yow Jen Lo, Ming Thau Sheu, Wen Chi Tsai, Yun Ho Lin, Jau Le Li, Yu Chih Liang, Chi Ching Chang, Ming-Shium Hsieh, Chien Ho Chen

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Combined effects of hyaluronate and indomethacin in the treatment of rabbits with antigen-induced arthritis (AIA) were evaluated by assessing joint swelling, C-reactive protein (CRP) and prostaglandin E₂ (PGE ₂) levels with periodic intra-articular (ia) injections of hyaluronate alone (HA group) and with either a low or high concentration of indomethacin (LI-HA or HI-HA group). End-point analyses included matrix metalloproteinases-3 (MMP-3) activity and macroscopic and histological joint examinations. Results demonstrated that treatment in LI-HA and HI-HA groups resulted in statistically significant suppression of CRP, PGE_2, and MMP-3 in comparison with those of HA group. Inhibition of serum CRP was only observed in LI-HA group. The order of serum MMP-3 inhibition was LI-HA>HI-HA>HA. Based on macroscopic and histological analyses of pannus formation, hyperplasia, inflammation, joint leakage and erosion, and loss of proteoglycan, the only statistically significant improvement was shown in LI-HA group compared to HA group and HI-HA group compared to control group.

Original language	English
Pages (from-to)	1099-1111
Number of pages	13
Journal	Rheumatology International
Volume	27
Issue number	12
DOIs	https://doi.org/10.1007/s00296-007-0346-1
Publication status	Published - Oct 2007

Keywords

Antigen-induced arthritis
CRP
Hyaluronate
Indomethacin
MMP
PGE

ASJC Scopus subject areas

Rheumatology

Access to Document

10.1007/s00296-007-0346-1

Fingerprint Dive into the research topics of 'Intra-articular injection of hyaluronate and indomethacin in rabbits with antigen-induced arthritis'. Together they form a unique fingerprint.

Cite this

Intra-articular injection of hyaluronate and indomethacin in rabbits with antigen-induced arthritis. / Lo, Yow Jen; Sheu, Ming Thau; Tsai, Wen Chi; Lin, Yun Ho; Li, Jau Le; Liang, Yu Chih ; Chang, Chi Ching; Hsieh, Ming-Shium; Chen, Chien Ho.

In: Rheumatology International, Vol. 27, No. 12, 10.2007, p. 1099-1111.

Research output: Contribution to journal › Article › peer-review

@article{15dfe07d86794102a6307e52c5261500,

title = "Intra-articular injection of hyaluronate and indomethacin in rabbits with antigen-induced arthritis",

abstract = "Combined effects of hyaluronate and indomethacin in the treatment of rabbits with antigen-induced arthritis (AIA) were evaluated by assessing joint swelling, C-reactive protein (CRP) and prostaglandin E2 (PGE 2) levels with periodic intra-articular (ia) injections of hyaluronate alone (HA group) and with either a low or high concentration of indomethacin (LI-HA or HI-HA group). End-point analyses included matrix metalloproteinases-3 (MMP-3) activity and macroscopic and histological joint examinations. Results demonstrated that treatment in LI-HA and HI-HA groups resulted in statistically significant suppression of CRP, PGE2, and MMP-3 in comparison with those of HA group. Inhibition of serum CRP was only observed in LI-HA group. The order of serum MMP-3 inhibition was LI-HA>HI-HA>HA. Based on macroscopic and histological analyses of pannus formation, hyperplasia, inflammation, joint leakage and erosion, and loss of proteoglycan, the only statistically significant improvement was shown in LI-HA group compared to HA group and HI-HA group compared to control group.",

keywords = "Antigen-induced arthritis, CRP, Hyaluronate, Indomethacin, MMP, PGE",

author = "Lo, {Yow Jen} and Sheu, {Ming Thau} and Tsai, {Wen Chi} and Lin, {Yun Ho} and Li, {Jau Le} and Liang, {Yu Chih} and Chang, {Chi Ching} and Ming-Shium Hsieh and Chen, {Chien Ho}",

year = "2007",

month = oct,

doi = "10.1007/s00296-007-0346-1",

language = "English",

volume = "27",

pages = "1099--1111",

journal = "Rheumatology International",

issn = "0172-8172",

publisher = "Springer Verlag",

number = "12",

}

TY - JOUR

T1 - Intra-articular injection of hyaluronate and indomethacin in rabbits with antigen-induced arthritis

AU - Lo, Yow Jen

AU - Sheu, Ming Thau

AU - Tsai, Wen Chi

AU - Lin, Yun Ho

AU - Li, Jau Le

AU - Liang, Yu Chih

AU - Chang, Chi Ching

AU - Hsieh, Ming-Shium

AU - Chen, Chien Ho

PY - 2007/10

Y1 - 2007/10

N2 - Combined effects of hyaluronate and indomethacin in the treatment of rabbits with antigen-induced arthritis (AIA) were evaluated by assessing joint swelling, C-reactive protein (CRP) and prostaglandin E2 (PGE 2) levels with periodic intra-articular (ia) injections of hyaluronate alone (HA group) and with either a low or high concentration of indomethacin (LI-HA or HI-HA group). End-point analyses included matrix metalloproteinases-3 (MMP-3) activity and macroscopic and histological joint examinations. Results demonstrated that treatment in LI-HA and HI-HA groups resulted in statistically significant suppression of CRP, PGE2, and MMP-3 in comparison with those of HA group. Inhibition of serum CRP was only observed in LI-HA group. The order of serum MMP-3 inhibition was LI-HA>HI-HA>HA. Based on macroscopic and histological analyses of pannus formation, hyperplasia, inflammation, joint leakage and erosion, and loss of proteoglycan, the only statistically significant improvement was shown in LI-HA group compared to HA group and HI-HA group compared to control group.

AB - Combined effects of hyaluronate and indomethacin in the treatment of rabbits with antigen-induced arthritis (AIA) were evaluated by assessing joint swelling, C-reactive protein (CRP) and prostaglandin E2 (PGE 2) levels with periodic intra-articular (ia) injections of hyaluronate alone (HA group) and with either a low or high concentration of indomethacin (LI-HA or HI-HA group). End-point analyses included matrix metalloproteinases-3 (MMP-3) activity and macroscopic and histological joint examinations. Results demonstrated that treatment in LI-HA and HI-HA groups resulted in statistically significant suppression of CRP, PGE2, and MMP-3 in comparison with those of HA group. Inhibition of serum CRP was only observed in LI-HA group. The order of serum MMP-3 inhibition was LI-HA>HI-HA>HA. Based on macroscopic and histological analyses of pannus formation, hyperplasia, inflammation, joint leakage and erosion, and loss of proteoglycan, the only statistically significant improvement was shown in LI-HA group compared to HA group and HI-HA group compared to control group.

KW - Antigen-induced arthritis

KW - CRP

KW - Hyaluronate

KW - Indomethacin

KW - MMP

KW - PGE

UR - http://www.scopus.com/inward/record.url?scp=34548489383&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548489383&partnerID=8YFLogxK

U2 - 10.1007/s00296-007-0346-1

DO - 10.1007/s00296-007-0346-1

M3 - Article

C2 - 17436002

AN - SCOPUS:34548489383

VL - 27

SP - 1099

EP - 1111

JO - Rheumatology International

JF - Rheumatology International

SN - 0172-8172

IS - 12

ER -

Intra-articular injection of hyaluronate and indomethacin in rabbits with antigen-induced arthritis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this