Intra-articular injection of hyaluronate and indomethacin in rabbits with antigen-induced arthritis

Yow Jen Lo, Ming Thau Sheu, Wen Chi Tsai, Yun Ho Lin, Jau Le Li, Yu Chih Liang, Chi Ching Chang, Ming-Shium Hsieh, Chien Ho Chen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Combined effects of hyaluronate and indomethacin in the treatment of rabbits with antigen-induced arthritis (AIA) were evaluated by assessing joint swelling, C-reactive protein (CRP) and prostaglandin E2 (PGE 2) levels with periodic intra-articular (ia) injections of hyaluronate alone (HA group) and with either a low or high concentration of indomethacin (LI-HA or HI-HA group). End-point analyses included matrix metalloproteinases-3 (MMP-3) activity and macroscopic and histological joint examinations. Results demonstrated that treatment in LI-HA and HI-HA groups resulted in statistically significant suppression of CRP, PGE2, and MMP-3 in comparison with those of HA group. Inhibition of serum CRP was only observed in LI-HA group. The order of serum MMP-3 inhibition was LI-HA>HI-HA>HA. Based on macroscopic and histological analyses of pannus formation, hyperplasia, inflammation, joint leakage and erosion, and loss of proteoglycan, the only statistically significant improvement was shown in LI-HA group compared to HA group and HI-HA group compared to control group.

Original languageEnglish
Pages (from-to)1099-1111
Number of pages13
JournalRheumatology International
Volume27
Issue number12
DOIs
Publication statusPublished - Oct 2007

Fingerprint

Intra-Articular Injections
Matrix Metalloproteinase 3
Indomethacin
C-Reactive Protein
Arthritis
Joints
Rabbits
Dinoprostone
Antigens
Proteoglycans
Hyperplasia
Blood Proteins
Inflammation
Control Groups
Therapeutics
Serum

Keywords

  • Antigen-induced arthritis
  • CRP
  • Hyaluronate
  • Indomethacin
  • MMP
  • PGE

ASJC Scopus subject areas

  • Rheumatology

Cite this

Intra-articular injection of hyaluronate and indomethacin in rabbits with antigen-induced arthritis. / Lo, Yow Jen; Sheu, Ming Thau; Tsai, Wen Chi; Lin, Yun Ho; Li, Jau Le; Liang, Yu Chih; Chang, Chi Ching; Hsieh, Ming-Shium; Chen, Chien Ho.

In: Rheumatology International, Vol. 27, No. 12, 10.2007, p. 1099-1111.

Research output: Contribution to journalArticle

@article{15dfe07d86794102a6307e52c5261500,
title = "Intra-articular injection of hyaluronate and indomethacin in rabbits with antigen-induced arthritis",
abstract = "Combined effects of hyaluronate and indomethacin in the treatment of rabbits with antigen-induced arthritis (AIA) were evaluated by assessing joint swelling, C-reactive protein (CRP) and prostaglandin E2 (PGE 2) levels with periodic intra-articular (ia) injections of hyaluronate alone (HA group) and with either a low or high concentration of indomethacin (LI-HA or HI-HA group). End-point analyses included matrix metalloproteinases-3 (MMP-3) activity and macroscopic and histological joint examinations. Results demonstrated that treatment in LI-HA and HI-HA groups resulted in statistically significant suppression of CRP, PGE2, and MMP-3 in comparison with those of HA group. Inhibition of serum CRP was only observed in LI-HA group. The order of serum MMP-3 inhibition was LI-HA>HI-HA>HA. Based on macroscopic and histological analyses of pannus formation, hyperplasia, inflammation, joint leakage and erosion, and loss of proteoglycan, the only statistically significant improvement was shown in LI-HA group compared to HA group and HI-HA group compared to control group.",
keywords = "Antigen-induced arthritis, CRP, Hyaluronate, Indomethacin, MMP, PGE",
author = "Lo, {Yow Jen} and Sheu, {Ming Thau} and Tsai, {Wen Chi} and Lin, {Yun Ho} and Li, {Jau Le} and Liang, {Yu Chih} and Chang, {Chi Ching} and Ming-Shium Hsieh and Chen, {Chien Ho}",
year = "2007",
month = "10",
doi = "10.1007/s00296-007-0346-1",
language = "English",
volume = "27",
pages = "1099--1111",
journal = "Rheumatology International",
issn = "0172-8172",
publisher = "Springer Verlag",
number = "12",

}

TY - JOUR

T1 - Intra-articular injection of hyaluronate and indomethacin in rabbits with antigen-induced arthritis

AU - Lo, Yow Jen

AU - Sheu, Ming Thau

AU - Tsai, Wen Chi

AU - Lin, Yun Ho

AU - Li, Jau Le

AU - Liang, Yu Chih

AU - Chang, Chi Ching

AU - Hsieh, Ming-Shium

AU - Chen, Chien Ho

PY - 2007/10

Y1 - 2007/10

N2 - Combined effects of hyaluronate and indomethacin in the treatment of rabbits with antigen-induced arthritis (AIA) were evaluated by assessing joint swelling, C-reactive protein (CRP) and prostaglandin E2 (PGE 2) levels with periodic intra-articular (ia) injections of hyaluronate alone (HA group) and with either a low or high concentration of indomethacin (LI-HA or HI-HA group). End-point analyses included matrix metalloproteinases-3 (MMP-3) activity and macroscopic and histological joint examinations. Results demonstrated that treatment in LI-HA and HI-HA groups resulted in statistically significant suppression of CRP, PGE2, and MMP-3 in comparison with those of HA group. Inhibition of serum CRP was only observed in LI-HA group. The order of serum MMP-3 inhibition was LI-HA>HI-HA>HA. Based on macroscopic and histological analyses of pannus formation, hyperplasia, inflammation, joint leakage and erosion, and loss of proteoglycan, the only statistically significant improvement was shown in LI-HA group compared to HA group and HI-HA group compared to control group.

AB - Combined effects of hyaluronate and indomethacin in the treatment of rabbits with antigen-induced arthritis (AIA) were evaluated by assessing joint swelling, C-reactive protein (CRP) and prostaglandin E2 (PGE 2) levels with periodic intra-articular (ia) injections of hyaluronate alone (HA group) and with either a low or high concentration of indomethacin (LI-HA or HI-HA group). End-point analyses included matrix metalloproteinases-3 (MMP-3) activity and macroscopic and histological joint examinations. Results demonstrated that treatment in LI-HA and HI-HA groups resulted in statistically significant suppression of CRP, PGE2, and MMP-3 in comparison with those of HA group. Inhibition of serum CRP was only observed in LI-HA group. The order of serum MMP-3 inhibition was LI-HA>HI-HA>HA. Based on macroscopic and histological analyses of pannus formation, hyperplasia, inflammation, joint leakage and erosion, and loss of proteoglycan, the only statistically significant improvement was shown in LI-HA group compared to HA group and HI-HA group compared to control group.

KW - Antigen-induced arthritis

KW - CRP

KW - Hyaluronate

KW - Indomethacin

KW - MMP

KW - PGE

UR - http://www.scopus.com/inward/record.url?scp=34548489383&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548489383&partnerID=8YFLogxK

U2 - 10.1007/s00296-007-0346-1

DO - 10.1007/s00296-007-0346-1

M3 - Article

C2 - 17436002

AN - SCOPUS:34548489383

VL - 27

SP - 1099

EP - 1111

JO - Rheumatology International

JF - Rheumatology International

SN - 0172-8172

IS - 12

ER -