Abstract
Combined effects of hyaluronate and indomethacin in the treatment of rabbits with antigen-induced arthritis (AIA) were evaluated by assessing joint swelling, C-reactive protein (CRP) and prostaglandin E2 (PGE 2) levels with periodic intra-articular (ia) injections of hyaluronate alone (HA group) and with either a low or high concentration of indomethacin (LI-HA or HI-HA group). End-point analyses included matrix metalloproteinases-3 (MMP-3) activity and macroscopic and histological joint examinations. Results demonstrated that treatment in LI-HA and HI-HA groups resulted in statistically significant suppression of CRP, PGE2, and MMP-3 in comparison with those of HA group. Inhibition of serum CRP was only observed in LI-HA group. The order of serum MMP-3 inhibition was LI-HA>HI-HA>HA. Based on macroscopic and histological analyses of pannus formation, hyperplasia, inflammation, joint leakage and erosion, and loss of proteoglycan, the only statistically significant improvement was shown in LI-HA group compared to HA group and HI-HA group compared to control group.
| Original language | English |
|---|---|
| Pages (from-to) | 1099-1111 |
| Number of pages | 13 |
| Journal | Rheumatology International |
| Volume | 27 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Oct 2007 |
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Keywords
- Antigen-induced arthritis
- CRP
- Hyaluronate
- Indomethacin
- MMP
- PGE
ASJC Scopus subject areas
- Rheumatology
Cite this
Intra-articular injection of hyaluronate and indomethacin in rabbits with antigen-induced arthritis. / Lo, Yow Jen; Sheu, Ming Thau; Tsai, Wen Chi; Lin, Yun Ho; Li, Jau Le; Liang, Yu Chih; Chang, Chi Ching; Hsieh, Ming-Shium; Chen, Chien Ho.
In: Rheumatology International, Vol. 27, No. 12, 10.2007, p. 1099-1111.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intra-articular injection of hyaluronate and indomethacin in rabbits with antigen-induced arthritis
AU - Lo, Yow Jen
AU - Sheu, Ming Thau
AU - Tsai, Wen Chi
AU - Lin, Yun Ho
AU - Li, Jau Le
AU - Liang, Yu Chih
AU - Chang, Chi Ching
AU - Hsieh, Ming-Shium
AU - Chen, Chien Ho
PY - 2007/10
Y1 - 2007/10
N2 - Combined effects of hyaluronate and indomethacin in the treatment of rabbits with antigen-induced arthritis (AIA) were evaluated by assessing joint swelling, C-reactive protein (CRP) and prostaglandin E2 (PGE 2) levels with periodic intra-articular (ia) injections of hyaluronate alone (HA group) and with either a low or high concentration of indomethacin (LI-HA or HI-HA group). End-point analyses included matrix metalloproteinases-3 (MMP-3) activity and macroscopic and histological joint examinations. Results demonstrated that treatment in LI-HA and HI-HA groups resulted in statistically significant suppression of CRP, PGE2, and MMP-3 in comparison with those of HA group. Inhibition of serum CRP was only observed in LI-HA group. The order of serum MMP-3 inhibition was LI-HA>HI-HA>HA. Based on macroscopic and histological analyses of pannus formation, hyperplasia, inflammation, joint leakage and erosion, and loss of proteoglycan, the only statistically significant improvement was shown in LI-HA group compared to HA group and HI-HA group compared to control group.
AB - Combined effects of hyaluronate and indomethacin in the treatment of rabbits with antigen-induced arthritis (AIA) were evaluated by assessing joint swelling, C-reactive protein (CRP) and prostaglandin E2 (PGE 2) levels with periodic intra-articular (ia) injections of hyaluronate alone (HA group) and with either a low or high concentration of indomethacin (LI-HA or HI-HA group). End-point analyses included matrix metalloproteinases-3 (MMP-3) activity and macroscopic and histological joint examinations. Results demonstrated that treatment in LI-HA and HI-HA groups resulted in statistically significant suppression of CRP, PGE2, and MMP-3 in comparison with those of HA group. Inhibition of serum CRP was only observed in LI-HA group. The order of serum MMP-3 inhibition was LI-HA>HI-HA>HA. Based on macroscopic and histological analyses of pannus formation, hyperplasia, inflammation, joint leakage and erosion, and loss of proteoglycan, the only statistically significant improvement was shown in LI-HA group compared to HA group and HI-HA group compared to control group.
KW - Antigen-induced arthritis
KW - CRP
KW - Hyaluronate
KW - Indomethacin
KW - MMP
KW - PGE
UR - http://www.scopus.com/inward/record.url?scp=34548489383&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548489383&partnerID=8YFLogxK
U2 - 10.1007/s00296-007-0346-1
DO - 10.1007/s00296-007-0346-1
M3 - Article
VL - 27
SP - 1099
EP - 1111
JO - Rheumatology International
JF - Rheumatology International
SN - 0172-8172
IS - 12
ER -