Intra-articular injection of hyaluronate and indomethacin in rabbits with antigen-induced arthritis

Yow Jen Lo; Ming Thau Sheu; Wen Chi Tsai; Yun Ho Lin; Jau Le Li; Yu Chih Liang; Chi Ching Chang; Ming-Shium Hsieh; Chien Ho Chen

doi:10.1007/s00296-007-0346-1

Intra-articular injection of hyaluronate and indomethacin in rabbits with antigen-induced arthritis

Yow Jen Lo, Ming Thau Sheu, Wen Chi Tsai, Yun Ho Lin, Jau Le Li, Yu Chih Liang, Chi Ching Chang, Ming-Shium Hsieh, Chien Ho Chen

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Combined effects of hyaluronate and indomethacin in the treatment of rabbits with antigen-induced arthritis (AIA) were evaluated by assessing joint swelling, C-reactive protein (CRP) and prostaglandin E₂ (PGE ₂) levels with periodic intra-articular (ia) injections of hyaluronate alone (HA group) and with either a low or high concentration of indomethacin (LI-HA or HI-HA group). End-point analyses included matrix metalloproteinases-3 (MMP-3) activity and macroscopic and histological joint examinations. Results demonstrated that treatment in LI-HA and HI-HA groups resulted in statistically significant suppression of CRP, PGE_2, and MMP-3 in comparison with those of HA group. Inhibition of serum CRP was only observed in LI-HA group. The order of serum MMP-3 inhibition was LI-HA>HI-HA>HA. Based on macroscopic and histological analyses of pannus formation, hyperplasia, inflammation, joint leakage and erosion, and loss of proteoglycan, the only statistically significant improvement was shown in LI-HA group compared to HA group and HI-HA group compared to control group.

Original language	English
Pages (from-to)	1099-1111
Number of pages	13
Journal	Rheumatology International
Volume	27
Issue number	12
DOIs	https://doi.org/10.1007/s00296-007-0346-1
Publication status	Published - Oct 2007

Keywords

Antigen-induced arthritis
CRP
Hyaluronate
Indomethacin
MMP
PGE

ASJC Scopus subject areas

Rheumatology

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10.1007/s00296-007-0346-1

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Intra-articular injection of hyaluronate and indomethacin in rabbits with antigen-induced arthritis. / Lo, Yow Jen; Sheu, Ming Thau; Tsai, Wen Chi; Lin, Yun Ho; Li, Jau Le; Liang, Yu Chih ; Chang, Chi Ching; Hsieh, Ming-Shium; Chen, Chien Ho.

In: Rheumatology International, Vol. 27, No. 12, 10.2007, p. 1099-1111.

Research output: Contribution to journal › Article › peer-review

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abstract = "Combined effects of hyaluronate and indomethacin in the treatment of rabbits with antigen-induced arthritis (AIA) were evaluated by assessing joint swelling, C-reactive protein (CRP) and prostaglandin E2 (PGE 2) levels with periodic intra-articular (ia) injections of hyaluronate alone (HA group) and with either a low or high concentration of indomethacin (LI-HA or HI-HA group). End-point analyses included matrix metalloproteinases-3 (MMP-3) activity and macroscopic and histological joint examinations. Results demonstrated that treatment in LI-HA and HI-HA groups resulted in statistically significant suppression of CRP, PGE2, and MMP-3 in comparison with those of HA group. Inhibition of serum CRP was only observed in LI-HA group. The order of serum MMP-3 inhibition was LI-HA>HI-HA>HA. Based on macroscopic and histological analyses of pannus formation, hyperplasia, inflammation, joint leakage and erosion, and loss of proteoglycan, the only statistically significant improvement was shown in LI-HA group compared to HA group and HI-HA group compared to control group.",

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author = "Lo, {Yow Jen} and Sheu, {Ming Thau} and Tsai, {Wen Chi} and Lin, {Yun Ho} and Li, {Jau Le} and Liang, {Yu Chih} and Chang, {Chi Ching} and Ming-Shium Hsieh and Chen, {Chien Ho}",

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AU - Lo, Yow Jen

AU - Sheu, Ming Thau

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AU - Lin, Yun Ho

AU - Li, Jau Le

AU - Liang, Yu Chih

AU - Chang, Chi Ching

AU - Hsieh, Ming-Shium

AU - Chen, Chien Ho

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AB - Combined effects of hyaluronate and indomethacin in the treatment of rabbits with antigen-induced arthritis (AIA) were evaluated by assessing joint swelling, C-reactive protein (CRP) and prostaglandin E2 (PGE 2) levels with periodic intra-articular (ia) injections of hyaluronate alone (HA group) and with either a low or high concentration of indomethacin (LI-HA or HI-HA group). End-point analyses included matrix metalloproteinases-3 (MMP-3) activity and macroscopic and histological joint examinations. Results demonstrated that treatment in LI-HA and HI-HA groups resulted in statistically significant suppression of CRP, PGE2, and MMP-3 in comparison with those of HA group. Inhibition of serum CRP was only observed in LI-HA group. The order of serum MMP-3 inhibition was LI-HA>HI-HA>HA. Based on macroscopic and histological analyses of pannus formation, hyperplasia, inflammation, joint leakage and erosion, and loss of proteoglycan, the only statistically significant improvement was shown in LI-HA group compared to HA group and HI-HA group compared to control group.

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KW - Indomethacin

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Intra-articular injection of hyaluronate and indomethacin in rabbits with antigen-induced arthritis

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