Interplay between Helicobacter pylori and immune cells in immune pathogenesis of gastric inflammation and mucosal pathology

Huei-Fang Tsai, Ping Ning Hsu

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

Helicobacter pylori infection is associated with an inflammatory response in the gastric mucosa, leading to chronic gastritis, peptic ulcers, gastric carcinoma and gastric mucosa-associated lymphoid tissue (MALT) lymphomas. Recent studies have shown that apoptosis of gastric epithelial cells is increased during H. pylori infection. Apoptosis induced by microbial infections are factors implicated in the pathogenesis of H. pylori infection. The enhanced gastric epithelial cell apoptosis in H. pylori infection has been suggested to play an important role in the pathogenesis of chronic gastritis and gastric pathology. In addition to directly triggering apoptosis, H. pylori induces sensitivity to tumor-necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in gastric epithelial cells via modulation of TRAIL apoptosis signaling. Moreover, H. pylori infection induces infiltration of T lymphocytes and triggers inflammation to augment apoptosis. In H. pylori infection, there was significantly increased CCR6 CD3 T-cell infiltration in the gastric mucosa, and the CCR6 ligand, CCL20 chemokine, was selectively expressed in inflamed gastric tissues. These results implicate that the interaction between CCL20 and CCR6 may play a role in recruiting T cells to the sites of inflammation in the gastric mucosa during Helicobacter infection. Through these mechanisms, chemokine-mediated T lymphocyte trafficking into inflamed epithelium is initiated and the mucosal injury in Helicobacter infection is induced. This article will review the recent novel findings on the interactions of H. pylori with diverse host epithelial signaling pathways and events involved in the initiation of gastric pathology, including gastric inflammation, mucosal damage and development of MALT lymphomas.

Original languageEnglish
Pages (from-to)255-259
Number of pages5
JournalCellular and Molecular Immunology
Volume7
Issue number4
DOIs
Publication statusPublished - Jul 2010

Fingerprint

Helicobacter Infections
Helicobacter pylori
Stomach
Apoptosis
Pathology
Inflammation
Gastric Mucosa
T-Lymphocytes
Marginal Zone B-Cell Lymphoma
Epithelial Cells
Gastritis
Chemokine CCL20
TNF-Related Apoptosis-Inducing Ligand
Ligands
Peptic Ulcer
Chemokines
Epithelium
Tumor Necrosis Factor-alpha
Carcinoma
Wounds and Injuries

Keywords

  • apoptosis
  • CagA
  • chemokine
  • Helicobacter pylori
  • TRAIL

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Interplay between Helicobacter pylori and immune cells in immune pathogenesis of gastric inflammation and mucosal pathology. / Tsai, Huei-Fang; Hsu, Ping Ning.

In: Cellular and Molecular Immunology, Vol. 7, No. 4, 07.2010, p. 255-259.

Research output: Contribution to journalReview article

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