Interleukin‐1β (IL‐1β) Is Increased in the Follicular Fluids of Patients With Premature Luteinization

HSIN‐FU ‐F CHEN, G‐NERNG ‐N HO, SHEE‐UAN ‐U CHEN, KUANG‐HAN ‐H CHAO, HENG‐RU ‐R LIN, SU‐CHENG ‐C HUANG, TZU‐YAO ‐Y LEE, YU‐SHIH ‐S YANG

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

PROBLEM: Most, but not all, studies indicate that premature luteinization correlates with poor pregnancy outcome in in‐vitro fertilization (IVF) programs. It remains unclear whether cytokines (IL‐1β, TNFα), the established immune mediators, play a role in regulation or initiation of an abnormal follicular or embryo development in patients with premature luteinization. METHODS: Levels of cytokines (IL‐1β, TNFα), estradiol (E2), progesterone (P4), and androstenedione (Aione) were examined in 18 preovulatory follicular fluid (FF) samples from patients with premature luteinization (group 1) and 37 FF samples from patients without premature luteinization (group 2). The number of oocytes recovered, fertilization rate, and pregnancy outcome were evaluated in these two groups. RESULTS: IL‐1β (25.4±11.9 pg/ml, mean ±SD) and TNFα (13.4±10.7 pg/ml) were present in these FF samples. The mean level of IL‐1β in group 1 was significantly higher than that in group 2 (37.3±12.3 vs. 20.0±7.6 pg/ml; P<0.00001) and the mean level of E2 was significantly lower in group 1 than that in group 2 (1064±686 vs. 1570±641 ng/ml; P=0.02). The levels of TNFα, P4, and A'ione showed no distinction between these two groups. There was no correlation between the levels of either IL‐1β or TNFα and P4, E2 or A'ione. The fertilization rate in group 1 (62/77; 80%) was similar to that in group 2 (124/160;78%). Five of 7 patients in group 1 and seven of 20 patients in group 2 achieved pregnancy following embryo transfer. One of five pregnancies in group 1 aborted. CONCLUSION: The exaggerated levels of IL‐1β in patients with premature luteinization may arise from accumulation of this cytokine owing to sustained high LH stimulation, and this may be a protective response to the abnormal LH surge and function to inhibit prematurely increased secretion of P4. These data indicate the important role of LH in the induction of IL‐1β secretion and the possible regulatory action of IL‐1β in luteinization. According to the diminution of E2 in group 1, there may be a subtle atretic process progressing in follicles primed with prematurely elevated LH. However, the detrimental effect of premature luteinization, if it exists, may work at the stage during or after implantation. 1995 Munksgaard

Original languageEnglish
Pages (from-to)356-362
Number of pages7
JournalAmerican Journal of Reproductive Immunology
Volume34
Issue number6
DOIs
Publication statusPublished - Jan 1 1995
Externally publishedYes

Fingerprint

Luteinization
Follicular Fluid
Follicular Phase
Ovulation Induction
Spontaneous Abortion
Fertilization in Vitro
Pregnancy Outcome
Luteinizing Hormone
Interleukin-1beta
Interleukin-1
Tumor Necrosis Factor-alpha
Cytokines
Pregnancy
Fertilization
Androstenedione
Embryo Transfer
Oocytes
Embryonic Development
Progesterone
Estradiol

Keywords

  • Cytokines
  • follicular fluid
  • in vitro fertilization
  • interleukin‐1β (IL‐1β)
  • premature luteinization
  • tumor necrosis factor a (TNFα)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Interleukin‐1β (IL‐1β) Is Increased in the Follicular Fluids of Patients With Premature Luteinization. / CHEN, HSIN‐FU ‐F; HO, G‐NERNG ‐N; CHEN, SHEE‐UAN ‐U; CHAO, KUANG‐HAN ‐H; LIN, HENG‐RU ‐R; HUANG, SU‐CHENG ‐C; LEE, TZU‐YAO ‐Y; YANG, YU‐SHIH ‐S.

In: American Journal of Reproductive Immunology, Vol. 34, No. 6, 01.01.1995, p. 356-362.

Research output: Contribution to journalArticle

CHEN, HSINFUF, HO, GNERNGN, CHEN, SHEEUANU, CHAO, KUANGHANH, LIN, HENGRUR, HUANG, SUCHENGC, LEE, TZUYAOY & YANG, YUSHIHS 1995, 'Interleukin‐1β (IL‐1β) Is Increased in the Follicular Fluids of Patients With Premature Luteinization', American Journal of Reproductive Immunology, vol. 34, no. 6, pp. 356-362. https://doi.org/10.1111/j.1600-0897.1995.tb00964.x
CHEN, HSIN‐FU ‐F ; HO, G‐NERNG ‐N ; CHEN, SHEE‐UAN ‐U ; CHAO, KUANG‐HAN ‐H ; LIN, HENG‐RU ‐R ; HUANG, SU‐CHENG ‐C ; LEE, TZU‐YAO ‐Y ; YANG, YU‐SHIH ‐S. / Interleukin‐1β (IL‐1β) Is Increased in the Follicular Fluids of Patients With Premature Luteinization. In: American Journal of Reproductive Immunology. 1995 ; Vol. 34, No. 6. pp. 356-362.
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AU - HO, G‐NERNG ‐N

AU - CHEN, SHEE‐UAN ‐U

AU - CHAO, KUANG‐HAN ‐H

AU - LIN, HENG‐RU ‐R

AU - HUANG, SU‐CHENG ‐C

AU - LEE, TZU‐YAO ‐Y

AU - YANG, YU‐SHIH ‐S

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N2 - PROBLEM: Most, but not all, studies indicate that premature luteinization correlates with poor pregnancy outcome in in‐vitro fertilization (IVF) programs. It remains unclear whether cytokines (IL‐1β, TNFα), the established immune mediators, play a role in regulation or initiation of an abnormal follicular or embryo development in patients with premature luteinization. METHODS: Levels of cytokines (IL‐1β, TNFα), estradiol (E2), progesterone (P4), and androstenedione (Aione) were examined in 18 preovulatory follicular fluid (FF) samples from patients with premature luteinization (group 1) and 37 FF samples from patients without premature luteinization (group 2). The number of oocytes recovered, fertilization rate, and pregnancy outcome were evaluated in these two groups. RESULTS: IL‐1β (25.4±11.9 pg/ml, mean ±SD) and TNFα (13.4±10.7 pg/ml) were present in these FF samples. The mean level of IL‐1β in group 1 was significantly higher than that in group 2 (37.3±12.3 vs. 20.0±7.6 pg/ml; P<0.00001) and the mean level of E2 was significantly lower in group 1 than that in group 2 (1064±686 vs. 1570±641 ng/ml; P=0.02). The levels of TNFα, P4, and A'ione showed no distinction between these two groups. There was no correlation between the levels of either IL‐1β or TNFα and P4, E2 or A'ione. The fertilization rate in group 1 (62/77; 80%) was similar to that in group 2 (124/160;78%). Five of 7 patients in group 1 and seven of 20 patients in group 2 achieved pregnancy following embryo transfer. One of five pregnancies in group 1 aborted. CONCLUSION: The exaggerated levels of IL‐1β in patients with premature luteinization may arise from accumulation of this cytokine owing to sustained high LH stimulation, and this may be a protective response to the abnormal LH surge and function to inhibit prematurely increased secretion of P4. These data indicate the important role of LH in the induction of IL‐1β secretion and the possible regulatory action of IL‐1β in luteinization. According to the diminution of E2 in group 1, there may be a subtle atretic process progressing in follicles primed with prematurely elevated LH. However, the detrimental effect of premature luteinization, if it exists, may work at the stage during or after implantation. 1995 Munksgaard

AB - PROBLEM: Most, but not all, studies indicate that premature luteinization correlates with poor pregnancy outcome in in‐vitro fertilization (IVF) programs. It remains unclear whether cytokines (IL‐1β, TNFα), the established immune mediators, play a role in regulation or initiation of an abnormal follicular or embryo development in patients with premature luteinization. METHODS: Levels of cytokines (IL‐1β, TNFα), estradiol (E2), progesterone (P4), and androstenedione (Aione) were examined in 18 preovulatory follicular fluid (FF) samples from patients with premature luteinization (group 1) and 37 FF samples from patients without premature luteinization (group 2). The number of oocytes recovered, fertilization rate, and pregnancy outcome were evaluated in these two groups. RESULTS: IL‐1β (25.4±11.9 pg/ml, mean ±SD) and TNFα (13.4±10.7 pg/ml) were present in these FF samples. The mean level of IL‐1β in group 1 was significantly higher than that in group 2 (37.3±12.3 vs. 20.0±7.6 pg/ml; P<0.00001) and the mean level of E2 was significantly lower in group 1 than that in group 2 (1064±686 vs. 1570±641 ng/ml; P=0.02). The levels of TNFα, P4, and A'ione showed no distinction between these two groups. There was no correlation between the levels of either IL‐1β or TNFα and P4, E2 or A'ione. The fertilization rate in group 1 (62/77; 80%) was similar to that in group 2 (124/160;78%). Five of 7 patients in group 1 and seven of 20 patients in group 2 achieved pregnancy following embryo transfer. One of five pregnancies in group 1 aborted. CONCLUSION: The exaggerated levels of IL‐1β in patients with premature luteinization may arise from accumulation of this cytokine owing to sustained high LH stimulation, and this may be a protective response to the abnormal LH surge and function to inhibit prematurely increased secretion of P4. These data indicate the important role of LH in the induction of IL‐1β secretion and the possible regulatory action of IL‐1β in luteinization. According to the diminution of E2 in group 1, there may be a subtle atretic process progressing in follicles primed with prematurely elevated LH. However, the detrimental effect of premature luteinization, if it exists, may work at the stage during or after implantation. 1995 Munksgaard

KW - Cytokines

KW - follicular fluid

KW - in vitro fertilization

KW - interleukin‐1β (IL‐1β)

KW - premature luteinization

KW - tumor necrosis factor a (TNFα)

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