Interleukin-28B genetic variants in identification of hepatitis C virus genotype 1 patients responding to 24 weeks peginterferon/ribavirin

Chung Feng Huang; Jee Fu Huang; Jeng Fu Yang; Ming Yen Hsieh; Zu Yau Lin; Shinn Cherng Chen; Liang Yen Wang; Suh Hang Hank Juo; Ku Chung Chen; Wan Long Chuang; Hsing Tao Kuo; Chia Yen Dai; Ming Lung Yu

doi:10.1016/j.jhep.2011.03.029

Interleukin-28B genetic variants in identification of hepatitis C virus genotype 1 patients responding to 24 weeks peginterferon/ribavirin

Chung Feng Huang, Jee Fu Huang, Jeng Fu Yang, Ming Yen Hsieh, Zu Yau Lin, Shinn Cherng Chen, Liang Yen Wang, Suh Hang Hank Juo, Ku Chung Chen, Wan Long Chuang, Hsing Tao Kuo, Chia Yen Dai, Ming Lung Yu

Research output: Contribution to journal › Article › peer-review

75 Citations (Scopus)

Abstract

Background & Aims: A substantial proportion of hepatitis C virus genotype 1 (HCV-1) patients achieved a sustained virological response (SVR, HCV RNA seronegative throughout 24 weeks of post-treatment follow-up) after 24 weeks peginterferon/ribavirin therapy. We explored the role of interleukin-28B genotype in identifying patients who responded to the regimen. Methods: Interleukin-28B rs8099917 genotype was determined in 226 HCV-1 patients with 24 weeks peginterferon/ribavirin. Results: Compared to patients with rs8099917 TG/GG genotype, those with TT genotype had significantly higher rapid virological response (RVR, HCV RNA seronegative at treatment week 4, 54.0% vs. 17.9%, p

Original language	English
Pages (from-to)	34-40
Number of pages	7
Journal	Journal of Hepatology
Volume	56
Issue number	1
DOIs	https://doi.org/10.1016/j.jhep.2011.03.029
Publication status	Published - Jan 2012
Externally published	Yes

Keywords

HCV
IL-28B
Tailored regimen
Treatment

ASJC Scopus subject areas

Hepatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jhep.2011.03.029

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Huang, C. F., Huang, J. F., Yang, J. F., Hsieh, M. Y., Lin, Z. Y., Chen, S. C., Wang, L. Y., Juo, S. H. H., Chen, K. C., Chuang, W. L., Kuo, H. T., Dai, C. Y., & Yu, M. L. (2012). Interleukin-28B genetic variants in identification of hepatitis C virus genotype 1 patients responding to 24 weeks peginterferon/ribavirin. Journal of Hepatology, 56(1), 34-40. https://doi.org/10.1016/j.jhep.2011.03.029

Huang, CF, Huang, JF, Yang, JF, Hsieh, MY, Lin, ZY, Chen, SC, Wang, LY, Juo, SHH, Chen, KC, Chuang, WL, Kuo, HT, Dai, CY & Yu, ML 2012, 'Interleukin-28B genetic variants in identification of hepatitis C virus genotype 1 patients responding to 24 weeks peginterferon/ribavirin', Journal of Hepatology, vol. 56, no. 1, pp. 34-40. https://doi.org/10.1016/j.jhep.2011.03.029

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title = "Interleukin-28B genetic variants in identification of hepatitis C virus genotype 1 patients responding to 24 weeks peginterferon/ribavirin",

abstract = "Background & Aims: A substantial proportion of hepatitis C virus genotype 1 (HCV-1) patients achieved a sustained virological response (SVR, HCV RNA seronegative throughout 24 weeks of post-treatment follow-up) after 24 weeks peginterferon/ribavirin therapy. We explored the role of interleukin-28B genotype in identifying patients who responded to the regimen. Methods: Interleukin-28B rs8099917 genotype was determined in 226 HCV-1 patients with 24 weeks peginterferon/ribavirin. Results: Compared to patients with rs8099917 TG/GG genotype, those with TT genotype had significantly higher rapid virological response (RVR, HCV RNA seronegative at treatment week 4, 54.0% vs. 17.9%, p ",

keywords = "HCV, IL-28B, Tailored regimen, Treatment",

author = "Huang, {Chung Feng} and Huang, {Jee Fu} and Yang, {Jeng Fu} and Hsieh, {Ming Yen} and Lin, {Zu Yau} and Chen, {Shinn Cherng} and Wang, {Liang Yen} and Juo, {Suh Hang Hank} and Chen, {Ku Chung} and Chuang, {Wan Long} and Kuo, {Hsing Tao} and Dai, {Chia Yen} and Yu, {Ming Lung}",

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doi = "10.1016/j.jhep.2011.03.029",

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AU - Huang, Chung Feng

AU - Huang, Jee Fu

AU - Yang, Jeng Fu

AU - Hsieh, Ming Yen

AU - Lin, Zu Yau

AU - Chen, Shinn Cherng

AU - Wang, Liang Yen

AU - Juo, Suh Hang Hank

AU - Chen, Ku Chung

AU - Chuang, Wan Long

AU - Kuo, Hsing Tao

AU - Dai, Chia Yen

AU - Yu, Ming Lung

PY - 2012/1

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AB - Background & Aims: A substantial proportion of hepatitis C virus genotype 1 (HCV-1) patients achieved a sustained virological response (SVR, HCV RNA seronegative throughout 24 weeks of post-treatment follow-up) after 24 weeks peginterferon/ribavirin therapy. We explored the role of interleukin-28B genotype in identifying patients who responded to the regimen. Methods: Interleukin-28B rs8099917 genotype was determined in 226 HCV-1 patients with 24 weeks peginterferon/ribavirin. Results: Compared to patients with rs8099917 TG/GG genotype, those with TT genotype had significantly higher rapid virological response (RVR, HCV RNA seronegative at treatment week 4, 54.0% vs. 17.9%, p

KW - HCV

KW - IL-28B

KW - Tailored regimen

KW - Treatment

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Interleukin-28B genetic variants in identification of hepatitis C virus genotype 1 patients responding to 24 weeks peginterferon/ribavirin

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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