Interleukin-23 receptor polymorphism as a risk factor for oral cancer susceptibility

Ming Hsien Chien; Chung Han Hsin; Lin Shih-Shen Chou; Tsung Te Chung; Chien Huang Lin; Meng Shih Weng; Ming Yung Chou; Mu Kuan Chen; Shun Fa Yang

doi:10.1002/hed.21779

Interleukin-23 receptor polymorphism as a risk factor for oral cancer susceptibility

Ming Hsien Chien, Chung Han Hsin, Lin Shih-Shen Chou, Tsung Te Chung, Chien Huang Lin, Meng Shih Weng, Ming Yung Chou, Mu Kuan Chen, Shun Fa Yang

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19 Citations (Scopus)

Abstract

Background The purpose of this study was to evaluate the influence of genetic polymorphisms of interleukin (IL)-23 and the IL-23 receptor (IL-23R) on the susceptibility to oral cancer. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure polymorphisms of these genes in 240 controls and 240 patients with oral cancer. Results Individuals with at least 1 varied C allele of rs10889677 (IL-23R polymorphism) had a 1.553-fold risk (95% confidence interval [CI], 1.073-2.241) of developing oral cancer compared with patients with the wild-type A/A homozygote. Patients with oral cancer with at least 1 varied C allele of rs10889677 had a 1.931-fold risk of tumor lymph node metastasis compared with patients with the C/C homozygote. Conclusion The varied C allele of the IL-23R gene may be considered a factor contributing to increased susceptibility and may be a predictive factor for tumor lymph node metastasis in Taiwanese with oral cancer.

Original language	English
Pages (from-to)	551-556
Number of pages	6
Journal	Head and Neck
Volume	34
Issue number	4
DOIs	https://doi.org/10.1002/hed.21779
Publication status	Published - Apr 2012

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Keywords

genetic polymorphism
IL-23
IL-23 receptor
oral cancer

ASJC Scopus subject areas

Otorhinolaryngology

Cite this

Chien, M. H., Hsin, C. H., Shih-Shen Chou, L., Chung, T. T., Lin, C. H., Weng, M. S., Chou, M. Y., Chen, M. K., & Yang, S. F. (2012). Interleukin-23 receptor polymorphism as a risk factor for oral cancer susceptibility. Head and Neck, 34(4), 551-556. https://doi.org/10.1002/hed.21779

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abstract = "Background The purpose of this study was to evaluate the influence of genetic polymorphisms of interleukin (IL)-23 and the IL-23 receptor (IL-23R) on the susceptibility to oral cancer. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure polymorphisms of these genes in 240 controls and 240 patients with oral cancer. Results Individuals with at least 1 varied C allele of rs10889677 (IL-23R polymorphism) had a 1.553-fold risk (95% confidence interval [CI], 1.073-2.241) of developing oral cancer compared with patients with the wild-type A/A homozygote. Patients with oral cancer with at least 1 varied C allele of rs10889677 had a 1.931-fold risk of tumor lymph node metastasis compared with patients with the C/C homozygote. Conclusion The varied C allele of the IL-23R gene may be considered a factor contributing to increased susceptibility and may be a predictive factor for tumor lymph node metastasis in Taiwanese with oral cancer.",

keywords = "genetic polymorphism, IL-23, IL-23 receptor, oral cancer",

author = "Chien, {Ming Hsien} and Hsin, {Chung Han} and {Shih-Shen Chou}, Lin and Chung, {Tsung Te} and Lin, {Chien Huang} and Weng, {Meng Shih} and Chou, {Ming Yung} and Chen, {Mu Kuan} and Yang, {Shun Fa}",

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T1 - Interleukin-23 receptor polymorphism as a risk factor for oral cancer susceptibility

AU - Chien, Ming Hsien

AU - Hsin, Chung Han

AU - Shih-Shen Chou, Lin

AU - Chung, Tsung Te

AU - Lin, Chien Huang

AU - Weng, Meng Shih

AU - Chou, Ming Yung

AU - Chen, Mu Kuan

AU - Yang, Shun Fa

PY - 2012/4

Y1 - 2012/4

N2 - Background The purpose of this study was to evaluate the influence of genetic polymorphisms of interleukin (IL)-23 and the IL-23 receptor (IL-23R) on the susceptibility to oral cancer. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure polymorphisms of these genes in 240 controls and 240 patients with oral cancer. Results Individuals with at least 1 varied C allele of rs10889677 (IL-23R polymorphism) had a 1.553-fold risk (95% confidence interval [CI], 1.073-2.241) of developing oral cancer compared with patients with the wild-type A/A homozygote. Patients with oral cancer with at least 1 varied C allele of rs10889677 had a 1.931-fold risk of tumor lymph node metastasis compared with patients with the C/C homozygote. Conclusion The varied C allele of the IL-23R gene may be considered a factor contributing to increased susceptibility and may be a predictive factor for tumor lymph node metastasis in Taiwanese with oral cancer.

AB - Background The purpose of this study was to evaluate the influence of genetic polymorphisms of interleukin (IL)-23 and the IL-23 receptor (IL-23R) on the susceptibility to oral cancer. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure polymorphisms of these genes in 240 controls and 240 patients with oral cancer. Results Individuals with at least 1 varied C allele of rs10889677 (IL-23R polymorphism) had a 1.553-fold risk (95% confidence interval [CI], 1.073-2.241) of developing oral cancer compared with patients with the wild-type A/A homozygote. Patients with oral cancer with at least 1 varied C allele of rs10889677 had a 1.931-fold risk of tumor lymph node metastasis compared with patients with the C/C homozygote. Conclusion The varied C allele of the IL-23R gene may be considered a factor contributing to increased susceptibility and may be a predictive factor for tumor lymph node metastasis in Taiwanese with oral cancer.

KW - genetic polymorphism

KW - IL-23

KW - IL-23 receptor

KW - oral cancer

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10.1002/hed.21779