Abstract
Background The purpose of this study was to evaluate the influence of genetic polymorphisms of interleukin (IL)-23 and the IL-23 receptor (IL-23R) on the susceptibility to oral cancer. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure polymorphisms of these genes in 240 controls and 240 patients with oral cancer. Results Individuals with at least 1 varied C allele of rs10889677 (IL-23R polymorphism) had a 1.553-fold risk (95% confidence interval [CI], 1.073-2.241) of developing oral cancer compared with patients with the wild-type A/A homozygote. Patients with oral cancer with at least 1 varied C allele of rs10889677 had a 1.931-fold risk of tumor lymph node metastasis compared with patients with the C/C homozygote. Conclusion The varied C allele of the IL-23R gene may be considered a factor contributing to increased susceptibility and may be a predictive factor for tumor lymph node metastasis in Taiwanese with oral cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 551-556 |
| Number of pages | 6 |
| Journal | Head and Neck |
| Volume | 34 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2012 |
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Keywords
- genetic polymorphism
- IL-23
- IL-23 receptor
- oral cancer
ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
Interleukin-23 receptor polymorphism as a risk factor for oral cancer susceptibility. / Chien, Ming Hsien; Hsin, Chung Han; Shih-Shen Chou, Lin; Chung, Tsung Te; Lin, Chien Huang; Weng, Meng Shih; Chou, Ming Yung; Chen, Mu Kuan; Yang, Shun Fa.
In: Head and Neck, Vol. 34, No. 4, 04.2012, p. 551-556.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interleukin-23 receptor polymorphism as a risk factor for oral cancer susceptibility
AU - Chien, Ming Hsien
AU - Hsin, Chung Han
AU - Shih-Shen Chou, Lin
AU - Chung, Tsung Te
AU - Lin, Chien Huang
AU - Weng, Meng Shih
AU - Chou, Ming Yung
AU - Chen, Mu Kuan
AU - Yang, Shun Fa
PY - 2012/4
Y1 - 2012/4
N2 - Background The purpose of this study was to evaluate the influence of genetic polymorphisms of interleukin (IL)-23 and the IL-23 receptor (IL-23R) on the susceptibility to oral cancer. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure polymorphisms of these genes in 240 controls and 240 patients with oral cancer. Results Individuals with at least 1 varied C allele of rs10889677 (IL-23R polymorphism) had a 1.553-fold risk (95% confidence interval [CI], 1.073-2.241) of developing oral cancer compared with patients with the wild-type A/A homozygote. Patients with oral cancer with at least 1 varied C allele of rs10889677 had a 1.931-fold risk of tumor lymph node metastasis compared with patients with the C/C homozygote. Conclusion The varied C allele of the IL-23R gene may be considered a factor contributing to increased susceptibility and may be a predictive factor for tumor lymph node metastasis in Taiwanese with oral cancer.
AB - Background The purpose of this study was to evaluate the influence of genetic polymorphisms of interleukin (IL)-23 and the IL-23 receptor (IL-23R) on the susceptibility to oral cancer. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure polymorphisms of these genes in 240 controls and 240 patients with oral cancer. Results Individuals with at least 1 varied C allele of rs10889677 (IL-23R polymorphism) had a 1.553-fold risk (95% confidence interval [CI], 1.073-2.241) of developing oral cancer compared with patients with the wild-type A/A homozygote. Patients with oral cancer with at least 1 varied C allele of rs10889677 had a 1.931-fold risk of tumor lymph node metastasis compared with patients with the C/C homozygote. Conclusion The varied C allele of the IL-23R gene may be considered a factor contributing to increased susceptibility and may be a predictive factor for tumor lymph node metastasis in Taiwanese with oral cancer.
KW - genetic polymorphism
KW - IL-23
KW - IL-23 receptor
KW - oral cancer
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UR - http://www.scopus.com/inward/citedby.url?scp=84858077257&partnerID=8YFLogxK
U2 - 10.1002/hed.21779
DO - 10.1002/hed.21779
M3 - Article
C2 - 21717520
AN - SCOPUS:84858077257
VL - 34
SP - 551
EP - 556
JO - Head and Neck
JF - Head and Neck
SN - 1043-3074
IS - 4
ER -