Interleukin-23 receptor polymorphism as a risk factor for oral cancer susceptibility

Ming Hsien Chien, Chung Han Hsin, Lin Shih-Shen Chou, Tsung Te Chung, Chien Huang Lin, Meng Shih Weng, Ming Yung Chou, Mu Kuan Chen, Shun Fa Yang

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20 Citations (Scopus)

Abstract

Background The purpose of this study was to evaluate the influence of genetic polymorphisms of interleukin (IL)-23 and the IL-23 receptor (IL-23R) on the susceptibility to oral cancer. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure polymorphisms of these genes in 240 controls and 240 patients with oral cancer. Results Individuals with at least 1 varied C allele of rs10889677 (IL-23R polymorphism) had a 1.553-fold risk (95% confidence interval [CI], 1.073-2.241) of developing oral cancer compared with patients with the wild-type A/A homozygote. Patients with oral cancer with at least 1 varied C allele of rs10889677 had a 1.931-fold risk of tumor lymph node metastasis compared with patients with the C/C homozygote. Conclusion The varied C allele of the IL-23R gene may be considered a factor contributing to increased susceptibility and may be a predictive factor for tumor lymph node metastasis in Taiwanese with oral cancer.

Original languageEnglish
Pages (from-to)551-556
Number of pages6
JournalHead and Neck
Volume34
Issue number4
DOIs
Publication statusPublished - Apr 2012

Keywords

  • genetic polymorphism
  • IL-23
  • IL-23 receptor
  • oral cancer

ASJC Scopus subject areas

  • Otorhinolaryngology

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    Chien, M. H., Hsin, C. H., Shih-Shen Chou, L., Chung, T. T., Lin, C. H., Weng, M. S., Chou, M. Y., Chen, M. K., & Yang, S. F. (2012). Interleukin-23 receptor polymorphism as a risk factor for oral cancer susceptibility. Head and Neck, 34(4), 551-556. https://doi.org/10.1002/hed.21779