Interleukin-19 in breast cancer

Ying Yin Chen, Chien Feng Li, Ching Hua Yeh, Ming Shi Chang, Chung-Hsi Hsing

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Inflammatory cytokines within the tumor microenvironment are linked to progression in breast cancer. Interleukin- (IL-) 19, part of the IL-10 family, contributes to a range of diseases and disorders, such as asthma, endotoxic shock, uremia, psoriasis, and rheumatoid arthritis. IL-19 is expressed in several types of tumor cells, especially in squamous cell carcinoma of the skin, tongue, esophagus, and lung and invasive duct carcinoma of the breast. In breast cancer, IL-19 expression is correlated with increased mitotic figures, advanced tumor stage, higher metastasis, and poor survival. The mechanisms of IL-19 in breast cancer have recently been explored both in vitro and in vivo. IL-19 has an autocrine effect in breast cancer cells. It directly promotes proliferation and migration and indirectly provides a microenvironment for tumor progression, which suggests that IL-19 is a prognostic marker in breast cancer and that antagonizing IL-19 may have therapeutic potential.

Original languageEnglish
Article number294320
JournalClinical and Developmental Immunology
Volume2013
DOIs
Publication statusPublished - 2013

Fingerprint

Interleukins
Breast Neoplasms
Tumor Microenvironment
Uremia
Septic Shock
Psoriasis
Tongue
Interleukin-10
Esophagus
Squamous Cell Carcinoma
Rheumatoid Arthritis
Neoplasms
Asthma
Cytokines
Neoplasm Metastasis
Lung
Skin

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

Chen, Y. Y., Li, C. F., Yeh, C. H., Chang, M. S., & Hsing, C-H. (2013). Interleukin-19 in breast cancer. Clinical and Developmental Immunology, 2013, [294320]. https://doi.org/10.1155/2013/294320

Interleukin-19 in breast cancer. / Chen, Ying Yin; Li, Chien Feng; Yeh, Ching Hua; Chang, Ming Shi; Hsing, Chung-Hsi.

In: Clinical and Developmental Immunology, Vol. 2013, 294320, 2013.

Research output: Contribution to journalArticle

Chen, YY, Li, CF, Yeh, CH, Chang, MS & Hsing, C-H 2013, 'Interleukin-19 in breast cancer', Clinical and Developmental Immunology, vol. 2013, 294320. https://doi.org/10.1155/2013/294320
Chen, Ying Yin ; Li, Chien Feng ; Yeh, Ching Hua ; Chang, Ming Shi ; Hsing, Chung-Hsi. / Interleukin-19 in breast cancer. In: Clinical and Developmental Immunology. 2013 ; Vol. 2013.
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