TY - JOUR
T1 - Interleukin-10 as a potential regulator of hepcidin homeostasis in overweight and obese children
T2 - A cross-sectional study in Taiwan
AU - Chang, Jung Su
AU - Li, Yu Ling
AU - Lu, Chiou Han
AU - Owaga, Eddy
AU - Chen, Wei Yu
AU - Chiou, Hung Yi
N1 - Funding Information:
J-S Chang was supported by a grant from the Taipei Medical University ( 102 TMU-TMUH-16 ) and the National Science Council Taiwan ( NSC102-2320-B-038-013 ). J-SC conceptualized and designed the study, drafted the initial manuscript, and approved the final manuscript as submitted. Y-LL supervised sample collection at four sites and carried out the initial analyses. EO contributed to the initiation of the project and supervision of recruitment. C-HL participated in the iron biochemistry analysis. W-YC contributed to the optimization of protocols and preparation and examination of cytokines measurements. H-YC critically reviewed the manuscript and approved the final manuscript as submitted. The authors have no financial relationships relevant to this article to disclose.
Publisher Copyright:
© 2014 Elsevier Inc.
PY - 2014
Y1 - 2014
N2 - Objective: A sharp increase in the prevalence of obesity and a decline in iron deficiency in children was observed between the two consecutive Nutrition and Health Surveys in Taiwan. The aim of this study was to evaluate the distribution of hepcidin in relation to nutritional status in children. Methods: 648 children ages 7 to 13 y living in Taipei and New Taipei City were enrolled in this study. Parameters for obesity, iron status, and inflammatory markers were evaluated. Results: There were no differences in the prevalence of iron deficiency and iron depletion between normal and overweight/obese children. A V-sharp hepcidin distribution curve was seen in normal weight children and overweight/obese boys. Serum hepcidin levels remained stable in overweight/obese girls during transition from childhood to teenager. Overweight/obese children had increased serum nitric oxide (NO) and interleukin (IL)-1β but decreased IL-10 concentration compared with normal weight children. A strong inverse relationship was found between IL-10 and body mass index (BMI; odds ratio (OR), 0.86, 95% confidence interval [CI], 0.83-0.89). By contrast, positive correlations were observed between BMI and IL-1β (OR, 1.60; 95% CI, 1.29-1.98); and between BMI and NO (OR, 1.04, 95% CI, 1.02-1.07). Multivariate linear regression analysis showed serum hepcidin was significantly correlated with IL-10 (β = 0.26, P < 0.0001). Conclusions: Our results raise the possibility that IL-10 may play a role in iron homeostasis. Decreased circulating IL-10 concentration may temporary protect young overweight/obese girls against the development of iron deficiency. However, long-term decrease in hepcidin concentration may increase the risk for iron overload in overweight/obese children.
AB - Objective: A sharp increase in the prevalence of obesity and a decline in iron deficiency in children was observed between the two consecutive Nutrition and Health Surveys in Taiwan. The aim of this study was to evaluate the distribution of hepcidin in relation to nutritional status in children. Methods: 648 children ages 7 to 13 y living in Taipei and New Taipei City were enrolled in this study. Parameters for obesity, iron status, and inflammatory markers were evaluated. Results: There were no differences in the prevalence of iron deficiency and iron depletion between normal and overweight/obese children. A V-sharp hepcidin distribution curve was seen in normal weight children and overweight/obese boys. Serum hepcidin levels remained stable in overweight/obese girls during transition from childhood to teenager. Overweight/obese children had increased serum nitric oxide (NO) and interleukin (IL)-1β but decreased IL-10 concentration compared with normal weight children. A strong inverse relationship was found between IL-10 and body mass index (BMI; odds ratio (OR), 0.86, 95% confidence interval [CI], 0.83-0.89). By contrast, positive correlations were observed between BMI and IL-1β (OR, 1.60; 95% CI, 1.29-1.98); and between BMI and NO (OR, 1.04, 95% CI, 1.02-1.07). Multivariate linear regression analysis showed serum hepcidin was significantly correlated with IL-10 (β = 0.26, P < 0.0001). Conclusions: Our results raise the possibility that IL-10 may play a role in iron homeostasis. Decreased circulating IL-10 concentration may temporary protect young overweight/obese girls against the development of iron deficiency. However, long-term decrease in hepcidin concentration may increase the risk for iron overload in overweight/obese children.
KW - Hepcidin
KW - IL-10
KW - Iron deficiency
KW - Obese children
KW - Taiwan
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U2 - 10.1016/j.nut.2014.02.021
DO - 10.1016/j.nut.2014.02.021
M3 - Article
C2 - 25194615
AN - SCOPUS:84908143993
SN - 0899-9007
VL - 30
SP - 1165
EP - 1170
JO - Nutrition
JF - Nutrition
IS - 10
ER -
