Abstract

Background: Interleukin 10 (IL-10) has multifaceted anti-inflammatory properties that are known to regulate insulin sensitivity and atherosclerotic development. However, studies in children are limited and have yielded conflicting results. The aim of this study was to evaluate whether changes in this circulating anti-inflammatory cytokine is a marker for metabolic syndrome. Materials and methods: This cross-sectional study involved children and young adolescents from eight elementary schools and two junior high schools located in Taipei and New Taipei City. A total of 553 children ages 8, 11 and 13 years old were included in the analysis. Parameters for obesity, anti- and pro-inflammatory cytokines, and metabolic risk profiles were evaluated. Results: Overweight/obese children had lower serum IL-10 concentrations compared with normal weight children in the same age group (all P 

Original languageEnglish
Pages (from-to)384-394
Number of pages11
JournalEuropean Journal of Clinical Investigation
Volume44
Issue number4
DOIs
Publication statusPublished - 2014

Keywords

  • Fasting plasma insulin
  • Interleukin 10
  • Metabolic syndrome
  • Obese children
  • Percentage body fat
  • Total cholesterol

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Biochemistry
  • Biochemistry

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