Abstract

Background: Interleukin 10 (IL-10) has multifaceted anti-inflammatory properties that are known to regulate insulin sensitivity and atherosclerotic development. However, studies in children are limited and have yielded conflicting results. The aim of this study was to evaluate whether changes in this circulating anti-inflammatory cytokine is a marker for metabolic syndrome. Materials and methods: This cross-sectional study involved children and young adolescents from eight elementary schools and two junior high schools located in Taipei and New Taipei City. A total of 553 children ages 8, 11 and 13 years old were included in the analysis. Parameters for obesity, anti- and pro-inflammatory cytokines, and metabolic risk profiles were evaluated. Results: Overweight/obese children had lower serum IL-10 concentrations compared with normal weight children in the same age group (all P 

Original languageEnglish
Pages (from-to)384-394
Number of pages11
JournalEuropean Journal of Clinical Investigation
Volume44
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

Pediatrics
Interleukin-10
Cluster Analysis
Anti-Inflammatory Agents
Cytokines
Metabolome
Insulin
Insulin Resistance
Age Groups
Obesity
Cross-Sectional Studies
Weights and Measures
Serum

Keywords

  • Fasting plasma insulin
  • Interleukin 10
  • Metabolic syndrome
  • Obese children
  • Percentage body fat
  • Total cholesterol

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Biochemistry
  • Biochemistry

Cite this

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title = "Interleukin 10 and clustering of metabolic syndrome components in pediatrics",
abstract = "Background: Interleukin 10 (IL-10) has multifaceted anti-inflammatory properties that are known to regulate insulin sensitivity and atherosclerotic development. However, studies in children are limited and have yielded conflicting results. The aim of this study was to evaluate whether changes in this circulating anti-inflammatory cytokine is a marker for metabolic syndrome. Materials and methods: This cross-sectional study involved children and young adolescents from eight elementary schools and two junior high schools located in Taipei and New Taipei City. A total of 553 children ages 8, 11 and 13 years old were included in the analysis. Parameters for obesity, anti- and pro-inflammatory cytokines, and metabolic risk profiles were evaluated. Results: Overweight/obese children had lower serum IL-10 concentrations compared with normal weight children in the same age group (all P ",
keywords = "Fasting plasma insulin, Interleukin 10, Metabolic syndrome, Obese children, Percentage body fat, Total cholesterol",
author = "Chang, {Jung Su} and Bai, {Chyi Huey} and Huang, {Zu Chieh} and Eddy Owaga and Chao, {Kuo Ching} and Chang, {Chun Chao} and Chiou, {Hung Yi}",
year = "2014",
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T1 - Interleukin 10 and clustering of metabolic syndrome components in pediatrics

AU - Chang, Jung Su

AU - Bai, Chyi Huey

AU - Huang, Zu Chieh

AU - Owaga, Eddy

AU - Chao, Kuo Ching

AU - Chang, Chun Chao

AU - Chiou, Hung Yi

PY - 2014

Y1 - 2014

N2 - Background: Interleukin 10 (IL-10) has multifaceted anti-inflammatory properties that are known to regulate insulin sensitivity and atherosclerotic development. However, studies in children are limited and have yielded conflicting results. The aim of this study was to evaluate whether changes in this circulating anti-inflammatory cytokine is a marker for metabolic syndrome. Materials and methods: This cross-sectional study involved children and young adolescents from eight elementary schools and two junior high schools located in Taipei and New Taipei City. A total of 553 children ages 8, 11 and 13 years old were included in the analysis. Parameters for obesity, anti- and pro-inflammatory cytokines, and metabolic risk profiles were evaluated. Results: Overweight/obese children had lower serum IL-10 concentrations compared with normal weight children in the same age group (all P 

AB - Background: Interleukin 10 (IL-10) has multifaceted anti-inflammatory properties that are known to regulate insulin sensitivity and atherosclerotic development. However, studies in children are limited and have yielded conflicting results. The aim of this study was to evaluate whether changes in this circulating anti-inflammatory cytokine is a marker for metabolic syndrome. Materials and methods: This cross-sectional study involved children and young adolescents from eight elementary schools and two junior high schools located in Taipei and New Taipei City. A total of 553 children ages 8, 11 and 13 years old were included in the analysis. Parameters for obesity, anti- and pro-inflammatory cytokines, and metabolic risk profiles were evaluated. Results: Overweight/obese children had lower serum IL-10 concentrations compared with normal weight children in the same age group (all P 

KW - Fasting plasma insulin

KW - Interleukin 10

KW - Metabolic syndrome

KW - Obese children

KW - Percentage body fat

KW - Total cholesterol

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JO - European Journal of Clinical Investigation

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