Interleukin-1 receptor antagonist increases survival in rat heatstroke by reducing hypothalamic serotonin release

Wen Ta Chiu, Ting Yu Kao, Mao Tsun Lin

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

During onset of heatstroke, rats displayed higher values of hypothalamic serotonin release and score of hypothalamic neuronal damage, and lower values of mean arterial pressure and hypothalamic blood flow compared with normothermic control rats. In another group in which interleukin-1 receptor antagonist (IL-1 ra; 200 μg/kg, i.v.) was injected 30 or 60 min after the start of heat exposure, the augmented hypothalamic serotonin release, diminished hypothalamic blood flow, arterial hypotension and hypothalamic neuronal damage during heatstroke were reduced as compared to the saline control group. The survival time (interval between onset of heatstroke and death) of the heatstroke rats was prolonged by treatment with IL-1 ra. The data indicate that IL-1 ra increases survival during rat heatstroke by reducing hypothalamic serotonin release.

Original languageEnglish
Pages (from-to)33-36
Number of pages4
JournalNeuroscience Letters
Volume202
Issue number1-2
DOIs
Publication statusPublished - Dec 29 1995

Keywords

  • Cerebral blood flow
  • Heatstroke
  • Hypothalamus
  • Interleukin-1 receptor antagonist
  • Neuronal death
  • Serotonin

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Interleukin-1 receptor antagonist increases survival in rat heatstroke by reducing hypothalamic serotonin release'. Together they form a unique fingerprint.

Cite this