Abstract
Objectives: Longitudinal studies in household contacts to identify subgroups at risk of active tuberculosis are lacking. Methods: Household contacts of pulmonary tuberculosis patients were prospectively enrolled to receive chest radiography, sputum studies, and T-SPOT.TB assay at initial visit. Repeat examinations every 6 months for 3 years, and 4-month rifampin preventive therapy for T-SPOT.TB-positive contacts were provided. We investigated factors predicting T-SPOT.TB-positivity and active pulmonary tuberculosis. Results: 583 contacts were enrolled with a follow-up duration of 20.7±9.4 months. 176 (30.2%) were T-SPOT.TB-positive initially and 32 (18.2%) of them received preventive therapy. Old age, living in the same room/house with the index case, the index case having a high smear grade (3+~4+) and pulmonary cavitation were associated with T-SPOT.TB-positivity. Active tuberculosis developed in 9T-SPOT.TB-positive contacts; risk factors included T-SPOT.TB-positivity without preventive therapy, living in the same room, and the index case being ≤50 years or female. 108 (61.4%) T-SPOT.TB-positive contacts had repeat examinations. Forty-five had T-SPOT.TB reversion and none of them developed active tuberculosis. Conclusion: Household contacts who are T-SPOT.TB-positive and live in the same room as the index case are at risk of active tuberculosis and require preventive therapy and close follow-up.
| Original language | English |
|---|---|
| Pages (from-to) | 291-298 |
| Number of pages | 8 |
| Journal | Journal of Infection |
| Volume | 64 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2012 |
| Externally published | Yes |
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Keywords
- Household contact
- Latent tuberculosis infection
- Pulmonary tuberculosis
- Risk factor
- T-SPOT.TB
- Taiwan
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases
Cite this
Interferon-gamma release assay and Rifampicin therapy for household contacts of tuberculosis. / Wang, Jann Yuan; Shu, Chin Chung; Lee, Chih Hsin; Yu, Chong Jen; Lee, Li Na; Yang, Pan Chyr.
In: Journal of Infection, Vol. 64, No. 3, 03.2012, p. 291-298.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interferon-gamma release assay and Rifampicin therapy for household contacts of tuberculosis
AU - Wang, Jann Yuan
AU - Shu, Chin Chung
AU - Lee, Chih Hsin
AU - Yu, Chong Jen
AU - Lee, Li Na
AU - Yang, Pan Chyr
PY - 2012/3
Y1 - 2012/3
N2 - Objectives: Longitudinal studies in household contacts to identify subgroups at risk of active tuberculosis are lacking. Methods: Household contacts of pulmonary tuberculosis patients were prospectively enrolled to receive chest radiography, sputum studies, and T-SPOT.TB assay at initial visit. Repeat examinations every 6 months for 3 years, and 4-month rifampin preventive therapy for T-SPOT.TB-positive contacts were provided. We investigated factors predicting T-SPOT.TB-positivity and active pulmonary tuberculosis. Results: 583 contacts were enrolled with a follow-up duration of 20.7±9.4 months. 176 (30.2%) were T-SPOT.TB-positive initially and 32 (18.2%) of them received preventive therapy. Old age, living in the same room/house with the index case, the index case having a high smear grade (3+~4+) and pulmonary cavitation were associated with T-SPOT.TB-positivity. Active tuberculosis developed in 9T-SPOT.TB-positive contacts; risk factors included T-SPOT.TB-positivity without preventive therapy, living in the same room, and the index case being ≤50 years or female. 108 (61.4%) T-SPOT.TB-positive contacts had repeat examinations. Forty-five had T-SPOT.TB reversion and none of them developed active tuberculosis. Conclusion: Household contacts who are T-SPOT.TB-positive and live in the same room as the index case are at risk of active tuberculosis and require preventive therapy and close follow-up.
AB - Objectives: Longitudinal studies in household contacts to identify subgroups at risk of active tuberculosis are lacking. Methods: Household contacts of pulmonary tuberculosis patients were prospectively enrolled to receive chest radiography, sputum studies, and T-SPOT.TB assay at initial visit. Repeat examinations every 6 months for 3 years, and 4-month rifampin preventive therapy for T-SPOT.TB-positive contacts were provided. We investigated factors predicting T-SPOT.TB-positivity and active pulmonary tuberculosis. Results: 583 contacts were enrolled with a follow-up duration of 20.7±9.4 months. 176 (30.2%) were T-SPOT.TB-positive initially and 32 (18.2%) of them received preventive therapy. Old age, living in the same room/house with the index case, the index case having a high smear grade (3+~4+) and pulmonary cavitation were associated with T-SPOT.TB-positivity. Active tuberculosis developed in 9T-SPOT.TB-positive contacts; risk factors included T-SPOT.TB-positivity without preventive therapy, living in the same room, and the index case being ≤50 years or female. 108 (61.4%) T-SPOT.TB-positive contacts had repeat examinations. Forty-five had T-SPOT.TB reversion and none of them developed active tuberculosis. Conclusion: Household contacts who are T-SPOT.TB-positive and live in the same room as the index case are at risk of active tuberculosis and require preventive therapy and close follow-up.
KW - Household contact
KW - Latent tuberculosis infection
KW - Pulmonary tuberculosis
KW - Risk factor
KW - T-SPOT.TB
KW - Taiwan
UR - http://www.scopus.com/inward/record.url?scp=84856598035&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856598035&partnerID=8YFLogxK
U2 - 10.1016/j.jinf.2011.11.028
DO - 10.1016/j.jinf.2011.11.028
M3 - Article
C2 - 22207002
AN - SCOPUS:84856598035
VL - 64
SP - 291
EP - 298
JO - Journal of Infection
JF - Journal of Infection
SN - 0163-4453
IS - 3
ER -