Interferon-β signaling contributes to ras transformation

Yu Chen Tsai, Sidney Pestka, Lu Hai Wang, Loren W. Runnels, Shan Wan, Yi Lisa Lyu, Leroy-Fong Liu

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Increasing evidence has pointed to activated type I interferon signaling in tumors. However, the molecular basis for such activation and its role in tumorigenesis remain unclear. In the current studies, we report that activation of type I interferon (IFN) signaling in tumor cells is primarily due to elevated secretion of the type I interferon, IFN-β. Studies in oncogene-transformed cells suggest that oncogenes such as Ras and Src can activate IFN-β signaling. Significantly, elevated IFN-β signaling in Ras-transformed mammary epithelial MCF-10A cells was shown to contribute to Ras transformation as evidenced by morphological changes, anchorage-independent growth, and migratory properties. Our results demonstrate for the first time that the type I IFN, IFN-β, contributes to Ras transformation and support the notion that oncogene-induced cytokines play important roles in oncogene transformation.

Original languageEnglish
Article numbere24291
JournalPLoS One
Volume6
Issue number8
DOIs
Publication statusPublished - Aug 29 2011
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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