Interactions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and clinicopathologic development

Feng Yan Lin; Chiao Wen Lin; Shun Fa Yang; Wei Jiunn Lee; Yung Wei Lin; Liang Ming Lee; Junn Liang Chang; Wei Chun Weng; Chien Huang Lin; Ming Hsien Chien

doi:10.1371/journal.pone.0121677

Interactions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and clinicopathologic development

Feng Yan Lin, Chiao Wen Lin, Shun Fa Yang, Wei Jiunn Lee, Yung Wei Lin, Liang Ming Lee, Junn Liang Chang, Wei Chun Weng, Chien Huang Lin, Ming Hsien Chien

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Background: The purpose of this study was to explore the combined effect of melatonin receptor type 1A (MTNR1A) gene polymorphisms and exposure to environmental carcinogens on the susceptibility and clinicopathological characteristics of oral cancer. Methodology and Principal Findings: Three polymorphisms of the MTNR1A gene from 618 patients with oral cancer and 560 non-cancer controls were analyzed by real-time polymerase chain reaction (PCR). The CTA haplotype of the studied MTNR1A polymorphisms (rs2119882, rs13140012, rs6553010) was related to a higher risk of oral cancer. Moreover, MTNR1A gene polymorphisms exhibited synergistic effects of environmental factors (betel quid and tobacco use) on the susceptibility of oral cancer. Finally, oral-cancer patients with betel quid-chewing habit who had T/T allele of MTNR1A rs13140012 were at higher risk for developing an advanced clinical stage and lymph node metastasis. Conclusion: These results support gene-environment interactions of MTNR1A polymorphisms with smoking and betel quid-chewing habits possibly altering oral-cancer susceptibility and metastasis.

Original language	English
Article number	e0121677
Journal	PLoS One
Volume	10
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0121677
Publication status	Published - Mar 25 2015

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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Lin, F. Y., Lin, C. W., Yang, S. F., Lee, W. J., Lin, Y. W., Lee, L. M., Chang, J. L., Weng, W. C., Lin, C. H., & Chien, M. H. (2015). Interactions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and clinicopathologic development. PLoS One, 10(3), [e0121677]. https://doi.org/10.1371/journal.pone.0121677

Interactions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and clinicopathologic development. / Lin, Feng Yan; Lin, Chiao Wen; Yang, Shun Fa; Lee, Wei Jiunn ; Lin, Yung Wei ; Lee, Liang Ming; Chang, Junn Liang; Weng, Wei Chun; Lin, Chien Huang ; Chien, Ming Hsien.

In: PLoS One, Vol. 10, No. 3, e0121677, 25.03.2015.

Research output: Contribution to journal › Article › peer-review

Lin, Feng Yan ; Lin, Chiao Wen ; Yang, Shun Fa ; Lee, Wei Jiunn ; Lin, Yung Wei ; Lee, Liang Ming ; Chang, Junn Liang ; Weng, Wei Chun ; Lin, Chien Huang ; Chien, Ming Hsien. / Interactions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and clinicopathologic development. In: PLoS One. 2015 ; Vol. 10, No. 3.

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abstract = "Background: The purpose of this study was to explore the combined effect of melatonin receptor type 1A (MTNR1A) gene polymorphisms and exposure to environmental carcinogens on the susceptibility and clinicopathological characteristics of oral cancer. Methodology and Principal Findings: Three polymorphisms of the MTNR1A gene from 618 patients with oral cancer and 560 non-cancer controls were analyzed by real-time polymerase chain reaction (PCR). The CTA haplotype of the studied MTNR1A polymorphisms (rs2119882, rs13140012, rs6553010) was related to a higher risk of oral cancer. Moreover, MTNR1A gene polymorphisms exhibited synergistic effects of environmental factors (betel quid and tobacco use) on the susceptibility of oral cancer. Finally, oral-cancer patients with betel quid-chewing habit who had T/T allele of MTNR1A rs13140012 were at higher risk for developing an advanced clinical stage and lymph node metastasis. Conclusion: These results support gene-environment interactions of MTNR1A polymorphisms with smoking and betel quid-chewing habits possibly altering oral-cancer susceptibility and metastasis.",

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N2 - Background: The purpose of this study was to explore the combined effect of melatonin receptor type 1A (MTNR1A) gene polymorphisms and exposure to environmental carcinogens on the susceptibility and clinicopathological characteristics of oral cancer. Methodology and Principal Findings: Three polymorphisms of the MTNR1A gene from 618 patients with oral cancer and 560 non-cancer controls were analyzed by real-time polymerase chain reaction (PCR). The CTA haplotype of the studied MTNR1A polymorphisms (rs2119882, rs13140012, rs6553010) was related to a higher risk of oral cancer. Moreover, MTNR1A gene polymorphisms exhibited synergistic effects of environmental factors (betel quid and tobacco use) on the susceptibility of oral cancer. Finally, oral-cancer patients with betel quid-chewing habit who had T/T allele of MTNR1A rs13140012 were at higher risk for developing an advanced clinical stage and lymph node metastasis. Conclusion: These results support gene-environment interactions of MTNR1A polymorphisms with smoking and betel quid-chewing habits possibly altering oral-cancer susceptibility and metastasis.

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