Interactions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and clinicopathologic development

Feng Yan Lin, Chiao Wen Lin, Shun Fa Yang, Wei Jiunn Lee, Yung Wei Lin, Liang Ming Lee, Junn Liang Chang, Wei Chun Weng, Chien Huang Lin, Ming Hsien Chien

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: The purpose of this study was to explore the combined effect of melatonin receptor type 1A (MTNR1A) gene polymorphisms and exposure to environmental carcinogens on the susceptibility and clinicopathological characteristics of oral cancer. Methodology and Principal Findings: Three polymorphisms of the MTNR1A gene from 618 patients with oral cancer and 560 non-cancer controls were analyzed by real-time polymerase chain reaction (PCR). The CTA haplotype of the studied MTNR1A polymorphisms (rs2119882, rs13140012, rs6553010) was related to a higher risk of oral cancer. Moreover, MTNR1A gene polymorphisms exhibited synergistic effects of environmental factors (betel quid and tobacco use) on the susceptibility of oral cancer. Finally, oral-cancer patients with betel quid-chewing habit who had T/T allele of MTNR1A rs13140012 were at higher risk for developing an advanced clinical stage and lymph node metastasis. Conclusion: These results support gene-environment interactions of MTNR1A polymorphisms with smoking and betel quid-chewing habits possibly altering oral-cancer susceptibility and metastasis.

Original languageEnglish
Article numbere0121677
JournalPLoS One
Volume10
Issue number3
DOIs
Publication statusPublished - Mar 25 2015

Fingerprint

Melatonin Receptors
Mouth Neoplasms
melatonin
Polymorphism
genetic polymorphism
betel
receptors
environmental factors
Genes
Mastication
mastication
metastasis
Habits
tobacco use
Environmental Carcinogens
Neoplasm Metastasis
Gene-Environment Interaction
genes
Tobacco
genotype-environment interaction

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Interactions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and clinicopathologic development. / Lin, Feng Yan; Lin, Chiao Wen; Yang, Shun Fa; Lee, Wei Jiunn; Lin, Yung Wei; Lee, Liang Ming; Chang, Junn Liang; Weng, Wei Chun; Lin, Chien Huang; Chien, Ming Hsien.

In: PLoS One, Vol. 10, No. 3, e0121677, 25.03.2015.

Research output: Contribution to journalArticle

@article{48a777fe371b4887b03fd8ee3c872123,
title = "Interactions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and clinicopathologic development",
abstract = "Background: The purpose of this study was to explore the combined effect of melatonin receptor type 1A (MTNR1A) gene polymorphisms and exposure to environmental carcinogens on the susceptibility and clinicopathological characteristics of oral cancer. Methodology and Principal Findings: Three polymorphisms of the MTNR1A gene from 618 patients with oral cancer and 560 non-cancer controls were analyzed by real-time polymerase chain reaction (PCR). The CTA haplotype of the studied MTNR1A polymorphisms (rs2119882, rs13140012, rs6553010) was related to a higher risk of oral cancer. Moreover, MTNR1A gene polymorphisms exhibited synergistic effects of environmental factors (betel quid and tobacco use) on the susceptibility of oral cancer. Finally, oral-cancer patients with betel quid-chewing habit who had T/T allele of MTNR1A rs13140012 were at higher risk for developing an advanced clinical stage and lymph node metastasis. Conclusion: These results support gene-environment interactions of MTNR1A polymorphisms with smoking and betel quid-chewing habits possibly altering oral-cancer susceptibility and metastasis.",
author = "Lin, {Feng Yan} and Lin, {Chiao Wen} and Yang, {Shun Fa} and Lee, {Wei Jiunn} and Lin, {Yung Wei} and Lee, {Liang Ming} and Chang, {Junn Liang} and Weng, {Wei Chun} and Lin, {Chien Huang} and Chien, {Ming Hsien}",
year = "2015",
month = "3",
day = "25",
doi = "10.1371/journal.pone.0121677",
language = "English",
volume = "10",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",

}

TY - JOUR

T1 - Interactions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and clinicopathologic development

AU - Lin, Feng Yan

AU - Lin, Chiao Wen

AU - Yang, Shun Fa

AU - Lee, Wei Jiunn

AU - Lin, Yung Wei

AU - Lee, Liang Ming

AU - Chang, Junn Liang

AU - Weng, Wei Chun

AU - Lin, Chien Huang

AU - Chien, Ming Hsien

PY - 2015/3/25

Y1 - 2015/3/25

N2 - Background: The purpose of this study was to explore the combined effect of melatonin receptor type 1A (MTNR1A) gene polymorphisms and exposure to environmental carcinogens on the susceptibility and clinicopathological characteristics of oral cancer. Methodology and Principal Findings: Three polymorphisms of the MTNR1A gene from 618 patients with oral cancer and 560 non-cancer controls were analyzed by real-time polymerase chain reaction (PCR). The CTA haplotype of the studied MTNR1A polymorphisms (rs2119882, rs13140012, rs6553010) was related to a higher risk of oral cancer. Moreover, MTNR1A gene polymorphisms exhibited synergistic effects of environmental factors (betel quid and tobacco use) on the susceptibility of oral cancer. Finally, oral-cancer patients with betel quid-chewing habit who had T/T allele of MTNR1A rs13140012 were at higher risk for developing an advanced clinical stage and lymph node metastasis. Conclusion: These results support gene-environment interactions of MTNR1A polymorphisms with smoking and betel quid-chewing habits possibly altering oral-cancer susceptibility and metastasis.

AB - Background: The purpose of this study was to explore the combined effect of melatonin receptor type 1A (MTNR1A) gene polymorphisms and exposure to environmental carcinogens on the susceptibility and clinicopathological characteristics of oral cancer. Methodology and Principal Findings: Three polymorphisms of the MTNR1A gene from 618 patients with oral cancer and 560 non-cancer controls were analyzed by real-time polymerase chain reaction (PCR). The CTA haplotype of the studied MTNR1A polymorphisms (rs2119882, rs13140012, rs6553010) was related to a higher risk of oral cancer. Moreover, MTNR1A gene polymorphisms exhibited synergistic effects of environmental factors (betel quid and tobacco use) on the susceptibility of oral cancer. Finally, oral-cancer patients with betel quid-chewing habit who had T/T allele of MTNR1A rs13140012 were at higher risk for developing an advanced clinical stage and lymph node metastasis. Conclusion: These results support gene-environment interactions of MTNR1A polymorphisms with smoking and betel quid-chewing habits possibly altering oral-cancer susceptibility and metastasis.

UR - http://www.scopus.com/inward/record.url?scp=84926393224&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926393224&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0121677

DO - 10.1371/journal.pone.0121677

M3 - Article

C2 - 25806809

AN - SCOPUS:84926393224

VL - 10

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 3

M1 - e0121677

ER -