Interactions between cigarette smoking and polymorphisms of xenobiotic-metabolizing genes: The risk of oral leukoplakia

Yu Fen Li, Fung Chang Sung, Ming Hsui Tsai, Chun Hung Hua, Chiu Shong Liu, Yao Te Huang, Chih Ching Yeh

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

BACKGROUND: This case-control study investigates the role of xenobiotic-metabolizing genes, including glutathione S-transferases (GSTs) and cytochrome P450 1A1 (CYP1A1) and 2E1 (CYP2E1), in the susceptibility to oral potentially malignant disorders (OPMDs). Methods: The genotypes of GSTM1, GSTT1, GSTP1, CYP1A1*2C, and CYP2E1 PstI/RsaI polymorphisms were determined for 217 OPMD cases and 492 age-and sex-matched controls from a Taiwanese penitentiary. Results: Compared to the GSTM1-present genotype, the GSTM1-null genotype was significantly associated with increased risk of leukoplakia (odds ratio [OR]=1.46, 95% confidence interval [CI]=1.01-2.10). Similarly, compared to the CYP1A1*2C A/G+G/G genotype, the CYP1A1*2C A/A genotype was significantly associated with increased risk of leukoplakia (OR=1.64, 95% CI=1.12-2.40), particularly for smokers consuming > 13 pack-years of cigarettes (OR=2.40, 95% CI=1.40-4.11) (Interaction P=0.039). In addition, participants with 4-5 risk genotypes (OR > 1) experienced higher risks for leukoplakia than those with 0-1 risk genotypes (OR=3.19, 95% CI=1.65-6.15) (Trend test P=0.001). Conclusions: Our findings suggest that the CYP1A1*2C A/A genotype may increase the risk of leukoplakia, especially for heavy smokers. Xenobiotic-metabolizing genes may simultaneously modulate this disease risk. These observations require further confirmation with larger samples.

Original languageEnglish
Pages (from-to)247-255
Number of pages9
JournalDisease Markers
Volume34
Issue number4
DOIs
Publication statusPublished - 2013

Keywords

  • cigarette smoking
  • cytochrome P450 1A1
  • cytochrome P450 2E1
  • Glutathione S-transferases
  • oral potentially malignant disorders
  • polymorphisms

ASJC Scopus subject areas

  • Biochemistry, medical
  • Clinical Biochemistry
  • Molecular Biology
  • Genetics

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