Interactions between cigarette smoking and polymorphisms of xenobiotic-metabolizing genes

The risk of oral leukoplakia

Yu Fen Li, Fung Chang Sung, Ming Hsui Tsai, Chun Hung Hua, Chiu Shong Liu, Yao Te Huang, Chih Ching Yeh

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

BACKGROUND: This case-control study investigates the role of xenobiotic-metabolizing genes, including glutathione S-transferases (GSTs) and cytochrome P450 1A1 (CYP1A1) and 2E1 (CYP2E1), in the susceptibility to oral potentially malignant disorders (OPMDs). Methods: The genotypes of GSTM1, GSTT1, GSTP1, CYP1A1*2C, and CYP2E1 PstI/RsaI polymorphisms were determined for 217 OPMD cases and 492 age-and sex-matched controls from a Taiwanese penitentiary. Results: Compared to the GSTM1-present genotype, the GSTM1-null genotype was significantly associated with increased risk of leukoplakia (odds ratio [OR]=1.46, 95% confidence interval [CI]=1.01-2.10). Similarly, compared to the CYP1A1*2C A/G+G/G genotype, the CYP1A1*2C A/A genotype was significantly associated with increased risk of leukoplakia (OR=1.64, 95% CI=1.12-2.40), particularly for smokers consuming > 13 pack-years of cigarettes (OR=2.40, 95% CI=1.40-4.11) (Interaction P=0.039). In addition, participants with 4-5 risk genotypes (OR > 1) experienced higher risks for leukoplakia than those with 0-1 risk genotypes (OR=3.19, 95% CI=1.65-6.15) (Trend test P=0.001). Conclusions: Our findings suggest that the CYP1A1*2C A/A genotype may increase the risk of leukoplakia, especially for heavy smokers. Xenobiotic-metabolizing genes may simultaneously modulate this disease risk. These observations require further confirmation with larger samples.

Original languageEnglish
Pages (from-to)247-255
Number of pages9
JournalDisease Markers
Volume34
Issue number4
DOIs
Publication statusPublished - 2013

Fingerprint

Oral Leukoplakia
Xenobiotics
Polymorphism
Tobacco Products
Genes
Smoking
Genotype
Leukoplakia
Cytochrome P-450 Enzyme System
Odds Ratio
Confidence Intervals
Prisons
Cytochrome P-450 CYP1A1
Cytochrome P-450 CYP2E1
Glutathione Transferase
Case-Control Studies

Keywords

  • cigarette smoking
  • cytochrome P450 1A1
  • cytochrome P450 2E1
  • Glutathione S-transferases
  • oral potentially malignant disorders
  • polymorphisms

ASJC Scopus subject areas

  • Biochemistry, medical
  • Clinical Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Interactions between cigarette smoking and polymorphisms of xenobiotic-metabolizing genes : The risk of oral leukoplakia. / Li, Yu Fen; Sung, Fung Chang; Tsai, Ming Hsui; Hua, Chun Hung; Liu, Chiu Shong; Huang, Yao Te; Yeh, Chih Ching.

In: Disease Markers, Vol. 34, No. 4, 2013, p. 247-255.

Research output: Contribution to journalArticle

Li, Yu Fen ; Sung, Fung Chang ; Tsai, Ming Hsui ; Hua, Chun Hung ; Liu, Chiu Shong ; Huang, Yao Te ; Yeh, Chih Ching. / Interactions between cigarette smoking and polymorphisms of xenobiotic-metabolizing genes : The risk of oral leukoplakia. In: Disease Markers. 2013 ; Vol. 34, No. 4. pp. 247-255.
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abstract = "BACKGROUND: This case-control study investigates the role of xenobiotic-metabolizing genes, including glutathione S-transferases (GSTs) and cytochrome P450 1A1 (CYP1A1) and 2E1 (CYP2E1), in the susceptibility to oral potentially malignant disorders (OPMDs). Methods: The genotypes of GSTM1, GSTT1, GSTP1, CYP1A1*2C, and CYP2E1 PstI/RsaI polymorphisms were determined for 217 OPMD cases and 492 age-and sex-matched controls from a Taiwanese penitentiary. Results: Compared to the GSTM1-present genotype, the GSTM1-null genotype was significantly associated with increased risk of leukoplakia (odds ratio [OR]=1.46, 95{\%} confidence interval [CI]=1.01-2.10). Similarly, compared to the CYP1A1*2C A/G+G/G genotype, the CYP1A1*2C A/A genotype was significantly associated with increased risk of leukoplakia (OR=1.64, 95{\%} CI=1.12-2.40), particularly for smokers consuming > 13 pack-years of cigarettes (OR=2.40, 95{\%} CI=1.40-4.11) (Interaction P=0.039). In addition, participants with 4-5 risk genotypes (OR > 1) experienced higher risks for leukoplakia than those with 0-1 risk genotypes (OR=3.19, 95{\%} CI=1.65-6.15) (Trend test P=0.001). Conclusions: Our findings suggest that the CYP1A1*2C A/A genotype may increase the risk of leukoplakia, especially for heavy smokers. Xenobiotic-metabolizing genes may simultaneously modulate this disease risk. These observations require further confirmation with larger samples.",
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T1 - Interactions between cigarette smoking and polymorphisms of xenobiotic-metabolizing genes

T2 - The risk of oral leukoplakia

AU - Li, Yu Fen

AU - Sung, Fung Chang

AU - Tsai, Ming Hsui

AU - Hua, Chun Hung

AU - Liu, Chiu Shong

AU - Huang, Yao Te

AU - Yeh, Chih Ching

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N2 - BACKGROUND: This case-control study investigates the role of xenobiotic-metabolizing genes, including glutathione S-transferases (GSTs) and cytochrome P450 1A1 (CYP1A1) and 2E1 (CYP2E1), in the susceptibility to oral potentially malignant disorders (OPMDs). Methods: The genotypes of GSTM1, GSTT1, GSTP1, CYP1A1*2C, and CYP2E1 PstI/RsaI polymorphisms were determined for 217 OPMD cases and 492 age-and sex-matched controls from a Taiwanese penitentiary. Results: Compared to the GSTM1-present genotype, the GSTM1-null genotype was significantly associated with increased risk of leukoplakia (odds ratio [OR]=1.46, 95% confidence interval [CI]=1.01-2.10). Similarly, compared to the CYP1A1*2C A/G+G/G genotype, the CYP1A1*2C A/A genotype was significantly associated with increased risk of leukoplakia (OR=1.64, 95% CI=1.12-2.40), particularly for smokers consuming > 13 pack-years of cigarettes (OR=2.40, 95% CI=1.40-4.11) (Interaction P=0.039). In addition, participants with 4-5 risk genotypes (OR > 1) experienced higher risks for leukoplakia than those with 0-1 risk genotypes (OR=3.19, 95% CI=1.65-6.15) (Trend test P=0.001). Conclusions: Our findings suggest that the CYP1A1*2C A/A genotype may increase the risk of leukoplakia, especially for heavy smokers. Xenobiotic-metabolizing genes may simultaneously modulate this disease risk. These observations require further confirmation with larger samples.

AB - BACKGROUND: This case-control study investigates the role of xenobiotic-metabolizing genes, including glutathione S-transferases (GSTs) and cytochrome P450 1A1 (CYP1A1) and 2E1 (CYP2E1), in the susceptibility to oral potentially malignant disorders (OPMDs). Methods: The genotypes of GSTM1, GSTT1, GSTP1, CYP1A1*2C, and CYP2E1 PstI/RsaI polymorphisms were determined for 217 OPMD cases and 492 age-and sex-matched controls from a Taiwanese penitentiary. Results: Compared to the GSTM1-present genotype, the GSTM1-null genotype was significantly associated with increased risk of leukoplakia (odds ratio [OR]=1.46, 95% confidence interval [CI]=1.01-2.10). Similarly, compared to the CYP1A1*2C A/G+G/G genotype, the CYP1A1*2C A/A genotype was significantly associated with increased risk of leukoplakia (OR=1.64, 95% CI=1.12-2.40), particularly for smokers consuming > 13 pack-years of cigarettes (OR=2.40, 95% CI=1.40-4.11) (Interaction P=0.039). In addition, participants with 4-5 risk genotypes (OR > 1) experienced higher risks for leukoplakia than those with 0-1 risk genotypes (OR=3.19, 95% CI=1.65-6.15) (Trend test P=0.001). Conclusions: Our findings suggest that the CYP1A1*2C A/A genotype may increase the risk of leukoplakia, especially for heavy smokers. Xenobiotic-metabolizing genes may simultaneously modulate this disease risk. These observations require further confirmation with larger samples.

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